Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              18    1135
XP_006716142                                                           18    1135
XP_005250088                                                           18    1135
XP_006716141                                                           18    1135
XP_005250085                                                           18    1135
XP_006716140                                                           18    1135
XP_005250084                                                           18    1135
XP_005250083                                                           18    1135
XP_005250082                                                           18    1135
NP_775734                                                              17    3301
NP_001129465                                                           17    3301
NP_694943                                                              17    3301
NP_001124198                                                           17    3301
XP_006722455                                                           17    3301
XP_005258255                                                           17    3301
XP_006714048                                                           17    3301
XP_005248267                                                           17    3301
XP_005246710                                                           16    5631
NP_061921                                                              16    5631
NP_001019832                                                           16    7355
NP_001278309                                                           16    7355
NP_075390                                                              16    7355
NP_001157576                                                           16    7355
NP_075389                                                              16    7355
NP_001157577                                                           16    7355
NP_061868                                                              16    7355
NP_055973                                                              16    7355
NP_001243805                                                           16    7355
NP_694856                                                              16    7355
NP_001243806                                                           16    7355
XP_006725017                                                           16    7355
XP_005261981                                                           16    7355
XP_006724481                                                           16    7355
XP_005261980                                                           16    7355
XP_006716811                                                           16    7355
XP_006716810                                                           16    7355
XP_005251476                                                           16    7355
XP_005251475                                                           16    7355
XP_005251473                                                           16    7355
XP_005251474                                                           16    7355
XP_005251472                                                           16    7355
XP_005251471                                                           16    7355
XP_005251470                                                           16    7355
XP_006716809                                                           16    7355
XP_006716808                                                           16    7355
XP_006716807                                                           16    7355
XP_006716806                                                           16    7355
XP_005251468                                                           16    7355
XP_005251467                                                           16    7355
XP_006711144                                                           16    7355
NP_003562                                                              15    9605
NP_001138604                                                           15    9605
>NP_733751
          Length = 4911

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES NSL
Sbjct: 112 VSEESANSL 120
>XP_006716142
          Length = 4927

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES NSL
Sbjct: 113 VSEESANSL 121
>XP_005250088
          Length = 4928

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES NSL
Sbjct: 113 VSEESANSL 121
>XP_006716141
          Length = 4959

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES NSL
Sbjct: 113 VSEESANSL 121
>XP_005250085
          Length = 4979

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES NSL
Sbjct: 113 VSEESANSL 121
>XP_006716140
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES NSL
Sbjct: 113 VSEESANSL 121
>XP_005250084
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES NSL
Sbjct: 113 VSEESANSL 121
>XP_005250083
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES NSL
Sbjct: 112 VSEESANSL 120
>XP_005250082
          Length = 4983

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES NSL
Sbjct: 113 VSEESANSL 121
>NP_775734
          Length = 529

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           SEE VNSL
Sbjct: 439 SEEEVNSL 446
>NP_001129465
          Length = 583

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES+N L
Sbjct: 207 VSEESLNRL 215
>NP_694943
          Length = 522

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES+N L
Sbjct: 146 VSEESLNRL 154
>NP_001124198
          Length = 529

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           SEE VNSL
Sbjct: 439 SEEEVNSL 446
>XP_006722455
          Length = 329

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES+N L
Sbjct: 207 VSEESLNRL 215
>XP_005258255
          Length = 522

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           VSEES+N L
Sbjct: 146 VSEESLNRL 154
>XP_006714048
          Length = 540

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           SEE VNSL
Sbjct: 450 SEEEVNSL 457
>XP_005248267
          Length = 540

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           SEE VNSL
Sbjct: 450 SEEEVNSL 457
>XP_005246710
          Length = 643

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           + EE+VNSL
Sbjct: 207 IIEENVNSL 215
>NP_061921
          Length = 643

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VSEESVNSL 9
           + EE+VNSL
Sbjct: 207 IIEENVNSL 215
>NP_001019832
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EESVNSL 9
           EES+NSL
Sbjct: 416 EESLNSL 422
>NP_001278309
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EESVNSL 9
           EES+NSL
Sbjct: 416 EESLNSL 422
>NP_075390
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EESVNSL 9
           EES+NSL
Sbjct: 416 EESLNSL 422
>NP_001157576
          Length = 1165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEESVNSL 9
           S+E++NSL
Sbjct: 344 SDENINSL 351
>NP_075389
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EESVNSL 9
           EES+NSL
Sbjct: 416 EESLNSL 422
>NP_001157577
          Length = 1165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEESVNSL 9
           S+E++NSL
Sbjct: 324 SDENINSL 331
>NP_061868
          Length = 1211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEESVNSL 9
           S+E++NSL
Sbjct: 344 SDENINSL 351
>NP_055973
          Length = 1352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 606 TEESVNDL 613
>NP_001243805
          Length = 1352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 606 TEESVNDL 613
>NP_694856
          Length = 1194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 448 TEESVNDL 455
>NP_001243806
          Length = 1352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 606 TEESVNDL 613
>XP_006725017
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EESVNSL 9
           EES+NSL
Sbjct: 171 EESLNSL 177
>XP_005261981
          Length = 970

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEESVNSL 9
           S+E++NSL
Sbjct: 103 SDENINSL 110
>XP_006724481
          Length = 1164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEESVNSL 9
           S+E++NSL
Sbjct: 297 SDENINSL 304
>XP_005261980
          Length = 1191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEESVNSL 9
           S+E++NSL
Sbjct: 324 SDENINSL 331
>XP_006716811
          Length = 1120

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 606 TEESVNDL 613
>XP_006716810
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 448 TEESVNDL 455
>XP_005251476
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 448 TEESVNDL 455
>XP_005251475
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 448 TEESVNDL 455
>XP_005251473
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 448 TEESVNDL 455
>XP_005251474
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 448 TEESVNDL 455
>XP_005251472
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 448 TEESVNDL 455
>XP_005251471
          Length = 1206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 448 TEESVNDL 455
>XP_005251470
          Length = 1284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 606 TEESVNDL 613
>XP_006716809
          Length = 1334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 606 TEESVNDL 613
>XP_006716808
          Length = 1346

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 606 TEESVNDL 613
>XP_006716807
          Length = 1352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 606 TEESVNDL 613
>XP_006716806
          Length = 1364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 606 TEESVNDL 613
>XP_005251468
          Length = 1364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 606 TEESVNDL 613
>XP_005251467
          Length = 1364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EESVN L
Sbjct: 606 TEESVNDL 613
>XP_006711144
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EESVNSL 9
           EES+NSL
Sbjct: 171 EESLNSL 177
>NP_003562
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SEESVNSL 9
           +EE +NSL
Sbjct: 202 AEEEINSL 209
>NP_001138604
          Length = 159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EESVNS 8
           EESVNS
Sbjct: 142 EESVNS 147
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.280    0.102    0.214 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 456,921
Number of extensions: 691
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.6 bits)
S2: 28 (15.4 bits)

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