Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_073713                                                              20     390
NP_078966                                                              17    4312
NP_002494                                                              16    5631
NP_005867                                                              16    5631
NP_001230045                                                           16    5631
XP_006723290                                                           16    5631
XP_006723289                                                           16    5631
XP_006712256                                                           16    5631
XP_005246298                                                           16    5631
XP_005246297                                                           16    5631
XP_005246299                                                           16    5631
XP_005246296                                                           16    5631
XP_006712254                                                           16    5631
XP_005246295                                                           16    5631
XP_006712253                                                           16    5631
XP_006712252                                                           16    5631
XP_005246294                                                           16    5631
XP_006712251                                                           16    5631
XP_005246293                                                           16    5631
XP_005246292                                                           16    5631
XP_006712250                                                           16    5631
NP_000593                                                              16    7355
NP_006508                                                              16    7355
XP_005255101                                                           16    7355
NP_150296                                                              16    7355
NP_002408                                                              15    9605
NP_001139438                                                           15    9605
NP_001229468                                                           15    9605
NP_054790                                                              15    9605
NP_001076                                                              15    9605
XP_006723818                                                           15    9605
XP_006723816                                                           15    9605
XP_006723815                                                           15    9605
XP_006723814                                                           15    9605
XP_006723813                                                           15    9605
XP_005260405                                                           15    9605
XP_006717927                                                           15    9605
>NP_073713
          Length = 985

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSAMLAPEP 9
           VS MLAPEP
Sbjct: 551 VSTMLAPEP 559
>NP_078966
          Length = 14507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VSAMLAPEP 9
            +SAM++P P
Sbjct: 7398 LSAMISPSP 7406
>NP_002494
          Length = 356

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SAMLAPEP 9
           SAML P P
Sbjct: 280 SAMLRPNP 287
>NP_005867
          Length = 3267

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2907 VSAPPAPEP 2915
>NP_001230045
          Length = 270

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SAMLAPEP 9
           SAML P P
Sbjct: 194 SAMLRPNP 201
>XP_006723290
          Length = 351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SAMLAPEP 9
           SAML P P
Sbjct: 275 SAMLRPNP 282
>XP_006723289
          Length = 416

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SAMLAPEP 9
           SAML P P
Sbjct: 340 SAMLRPNP 347
>XP_006712256
          Length = 2418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2058 VSAPPAPEP 2066
>XP_005246298
          Length = 2418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2058 VSAPPAPEP 2066
>XP_005246297
          Length = 2418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2058 VSAPPAPEP 2066
>XP_005246299
          Length = 2480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2120 VSAPPAPEP 2128
>XP_005246296
          Length = 2475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2115 VSAPPAPEP 2123
>XP_006712254
          Length = 2475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2115 VSAPPAPEP 2123
>XP_005246295
          Length = 3114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2754 VSAPPAPEP 2762
>XP_006712253
          Length = 3117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2757 VSAPPAPEP 2765
>XP_006712252
          Length = 3163

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2803 VSAPPAPEP 2811
>XP_005246294
          Length = 3173

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2813 VSAPPAPEP 2821
>XP_006712251
          Length = 3176

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2816 VSAPPAPEP 2824
>XP_005246293
          Length = 3206

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2846 VSAPPAPEP 2854
>XP_005246292
          Length = 3208

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2848 VSAPPAPEP 2856
>XP_006712250
          Length = 3248

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSAMLAPEP 9
            VSA  APEP
Sbjct: 2888 VSAPPAPEP 2896
>NP_000593
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSAMLAPE 8
           VSA +APE
Sbjct: 366 VSARMAPE 373
>NP_006508
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MLAPEP 9
           MLAP+P
Sbjct: 517 MLAPDP 522
>XP_005255101
          Length = 922

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSAMLAPEP 9
           V AML+P P
Sbjct: 754 VGAMLSPLP 762
>NP_150296
          Length = 974

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSAMLAPEP 9
           V AML+P P
Sbjct: 806 VGAMLSPLP 814
>NP_002408
          Length = 3256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    AMLAPEP 9
            AML P+P
Sbjct: 1173 AMLTPKP 1179
>NP_001139438
          Length = 2896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AMLAPEP 9
           AML P+P
Sbjct: 813 AMLTPKP 819
>NP_001229468
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAMLAPEP 9
           S+M+AP P
Sbjct: 192 SSMMAPGP 199
>NP_054790
          Length = 2063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAMLAPEP 9
           S+M+AP P
Sbjct: 192 SSMMAPGP 199
>NP_001076
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VSAMLAPE 8
           V AML PE
Sbjct: 287 VEAMLLPE 294
>XP_006723818
          Length = 1975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAMLAPEP 9
           S+M+AP P
Sbjct: 192 SSMMAPGP 199
>XP_006723816
          Length = 2034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAMLAPEP 9
           S+M+AP P
Sbjct: 192 SSMMAPGP 199
>XP_006723815
          Length = 2051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAMLAPEP 9
           S+M+AP P
Sbjct: 192 SSMMAPGP 199
>XP_006723814
          Length = 2052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAMLAPEP 9
           S+M+AP P
Sbjct: 192 SSMMAPGP 199
>XP_006723813
          Length = 2062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAMLAPEP 9
           S+M+AP P
Sbjct: 192 SSMMAPGP 199
>XP_005260405
          Length = 2063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SAMLAPEP 9
           S+M+AP P
Sbjct: 192 SSMMAPGP 199
>XP_006717927
          Length = 2406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AMLAPEP 9
           AML P+P
Sbjct: 323 AMLTPKP 329
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.122    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 908,109
Number of extensions: 667
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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