Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001032238                                                           17    4312
NP_006812                                                              17    4312
XP_005256795                                                           17    4312
NP_002887                                                              16    5631
NP_001070143                                                           16    5631
NP_660340                                                              16    5631
NP_001129120                                                           16    5631
NP_113680                                                              16    5631
NP_002835                                                              16    5631
NP_001185774                                                           16    5631
XP_006725089                                                           16    5631
XP_006725088                                                           16    5631
XP_006725087                                                           16    5631
XP_006725086                                                           16    5631
XP_006725085                                                           16    5631
XP_006725084                                                           16    5631
XP_006725083                                                           16    5631
XP_006725082                                                           16    5631
XP_006715604                                                           16    5631
XP_006715603                                                           16    5631
XP_005267143                                                           16    5631
XP_006715602                                                           16    5631
XP_006715601                                                           16    5631
XP_005267142                                                           16    5631
XP_006715600                                                           16    5631
XP_005267139                                                           16    5631
XP_006715599                                                           16    5631
XP_006715598                                                           16    5631
NP_001269388                                                           16    7355
NP_001171313                                                           16    7355
NP_003130                                                              16    7355
NP_005550                                                              16    7355
XP_005262993                                                           16    7355
XP_005262994                                                           16    7355
NP_938022                                                              16    7355
NP_005752                                                              15    9605
NP_060103                                                              15    9605
NP_060350                                                              15    9605
XP_005259613                                                           15    9605
XP_006719249                                                           15    9605
XP_005264448                                                           15    9605
XP_005264447                                                           15    9605
XP_005264446                                                           15    9605
NP_443175                                                              15    9605
>NP_001032238
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           VRTPL ++L
Sbjct: 98  VRTPLAVEL 106
>NP_006812
          Length = 483

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           VRTPL ++L
Sbjct: 160 VRTPLAVEL 168
>XP_005256795
          Length = 294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RTPLTM 7
           RTPLTM
Sbjct: 245 RTPLTM 250
>NP_002887
          Length = 364

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VRTPLTM 7
           VRTP TM
Sbjct: 197 VRTPYTM 203
>NP_001070143
          Length = 528

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RTPLTMK 8
          R PLTMK
Sbjct: 60 RKPLTMK 66
>NP_660340
          Length = 92

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RTPLTMK 8
          R PLTMK
Sbjct: 60 RKPLTMK 66
>NP_001129120
          Length = 1446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>NP_113680
          Length = 359

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VRTPLTM 7
           VRTP TM
Sbjct: 197 VRTPYTM 203
>NP_002835
          Length = 1440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>NP_001185774
          Length = 339

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VRTPLTM 7
           VRTP TM
Sbjct: 172 VRTPYTM 178
>XP_006725089
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_006725088
          Length = 866

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_006725087
          Length = 869

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_006725086
          Length = 1057

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 VRTPLTMKL 9
         +RTP T+K+
Sbjct: 1 MRTPKTLKI 9
>XP_006725085
          Length = 1375

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 319 MRTPKTLKI 327
>XP_006725084
          Length = 1375

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 319 MRTPKTLKI 327
>XP_006725083
          Length = 1439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_006725082
          Length = 1445

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_006715604
          Length = 869

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_006715603
          Length = 869

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_005267143
          Length = 890

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_006715602
          Length = 893

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_006715601
          Length = 1081

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1 VRTPLTMKL 9
         +RTP T+K+
Sbjct: 1 MRTPKTLKI 9
>XP_005267142
          Length = 1439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_006715600
          Length = 1445

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_005267139
          Length = 1464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_006715599
          Length = 1469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>XP_006715598
          Length = 1470

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           +RTP T+K+
Sbjct: 390 MRTPKTLKI 398
>NP_001269388
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VRTPLTMKL 9
           +RTPLT  L
Sbjct: 308 LRTPLTAHL 316
>NP_001171313
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VRTPLTMK 8
           +R P TMK
Sbjct: 102 IRAPTTMK 109
>NP_003130
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VRTPLTMK 8
           +R P TMK
Sbjct: 130 IRAPTTMK 137
>NP_005550
          Length = 3075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    VRTPLTM 7
            VRTP+T+
Sbjct: 1166 VRTPVTL 1172
>XP_005262993
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VRTPLTM 7
           + TPLTM
Sbjct: 122 IHTPLTM 128
>XP_005262994
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VRTPLTM 7
           + TPLTM
Sbjct: 122 IHTPLTM 128
>NP_938022
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VRTPLTM 7
           + TPLTM
Sbjct: 122 IHTPLTM 128
>NP_005752
          Length = 1568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           VRT +T+KL
Sbjct: 818 VRTNVTVKL 826
>NP_060103
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TPLTMK 8
           TPLT+K
Sbjct: 179 TPLTLK 184
>NP_060350
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TPLTMK 8
           TPLT+K
Sbjct: 147 TPLTLK 152
>XP_005259613
          Length = 267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  VRTPLT 6
          VRTP+T
Sbjct: 18 VRTPMT 23
>XP_006719249
          Length = 1555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VRTPLTMKL 9
           VRT +T+KL
Sbjct: 818 VRTNVTVKL 826
>XP_005264448
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TPLTMK 8
           TPLT+K
Sbjct: 147 TPLTLK 152
>XP_005264447
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TPLTMK 8
           TPLT+K
Sbjct: 147 TPLTLK 152
>XP_005264446
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TPLTMK 8
           TPLT+K
Sbjct: 147 TPLTLK 152
>NP_443175
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TPLTMK 8
           TPLT+K
Sbjct: 165 TPLTLK 170
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.136    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 632,288
Number of extensions: 869
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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