Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1482
NP_671714                                                              18    1482
XP_006715890                                                           18    1482
XP_005250160                                                           18    1482
XP_005250159                                                           18    1482
XP_006714139                                                           17    3301
NP_001177779                                                           17    4312
NP_001177776                                                           17    4312
NP_037448                                                              17    4312
NP_001008226                                                           17    4312
NP_001177778                                                           17    4312
NP_001177777                                                           17    4312
NP_775082                                                              16    5631
NP_003377                                                              16    5631
NP_006651                                                              16    5631
NP_001284                                                              16    5631
NP_055935                                                              16    7355
NP_060522                                                              16    7355
NP_060439                                                              16    7355
XP_005256097                                                           16    7355
XP_006712689                                                           16    7355
XP_005263764                                                           16    7355
>NP_005742
          Length = 3907

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VRTEDALKS 9
            V TEDALKS
Sbjct: 2468 VLTEDALKS 2476
>NP_671714
          Length = 3899

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VRTEDALKS 9
            V TEDALKS
Sbjct: 2460 VLTEDALKS 2468
>XP_006715890
          Length = 3860

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VRTEDALKS 9
            V TEDALKS
Sbjct: 2421 VLTEDALKS 2429
>XP_005250160
          Length = 3939

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VRTEDALKS 9
            V TEDALKS
Sbjct: 2500 VLTEDALKS 2508
>XP_005250159
          Length = 3952

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VRTEDALKS 9
            V TEDALKS
Sbjct: 2513 VLTEDALKS 2521
>XP_006714139
          Length = 950

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VRTEDALK 8
           V TEDALK
Sbjct: 940 VSTEDALK 947
>NP_001177779
          Length = 713

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VRTEDALKS 9
           +R+EDAL++
Sbjct: 164 IRSEDALRA 172
>NP_001177776
          Length = 642

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VRTEDALKS 9
           +R+EDAL++
Sbjct: 164 IRSEDALRA 172
>NP_037448
          Length = 639

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VRTEDALKS 9
           +R+EDAL++
Sbjct: 164 IRSEDALRA 172
>NP_001008226
          Length = 572

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VRTEDALKS 9
           +R+EDAL++
Sbjct: 164 IRSEDALRA 172
>NP_001177778
          Length = 710

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VRTEDALKS 9
           +R+EDAL++
Sbjct: 164 IRSEDALRA 172
>NP_001177777
          Length = 575

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VRTEDALKS 9
           +R+EDAL++
Sbjct: 164 IRSEDALRA 172
>NP_775082
          Length = 2721

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    VRTEDAL 7
            V+TEDAL
Sbjct: 2499 VKTEDAL 2505
>NP_003377
          Length = 2812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    VRTEDAL 7
            V+TEDAL
Sbjct: 2499 VKTEDAL 2505
>NP_006651
          Length = 633

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TEDALKS 9
           TEDALK+
Sbjct: 543 TEDALKA 549
>NP_001284
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VRTEDALK 8
           VRTED+++
Sbjct: 205 VRTEDSIR 212
>NP_055935
          Length = 4169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    TEDALK 8
            TEDALK
Sbjct: 2163 TEDALK 2168
>NP_060522
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VRTEDALKS 9
           ++TED+LK+
Sbjct: 726 LQTEDSLKA 734
>NP_060439
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TEDALK 8
           TEDALK
Sbjct: 174 TEDALK 179
>XP_005256097
          Length = 754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VRTEDALKS 9
           ++TED+LK+
Sbjct: 698 LQTEDSLKA 706
>XP_006712689
          Length = 823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TEDALK 8
           TEDALK
Sbjct: 179 TEDALK 184
>XP_005263764
          Length = 824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TEDALK 8
           TEDALK
Sbjct: 179 TEDALK 184
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.118    0.278 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 448,532
Number of extensions: 607
Number of successful extensions: 22
Number of sequences better than 10000.0: 22
Number of HSP's gapped: 22
Number of HSP's successfully gapped: 22
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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