Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065681                                                              20     390
NP_066124                                                              20     390
XP_006717999                                                           20     390
NP_004527                                                              17    4312
NP_075043                                                              17    4312
XP_006725521                                                           17    4312
XP_006725520                                                           17    4312
XP_006725519                                                           17    4312
XP_006725518                                                           17    4312
XP_006725517                                                           17    4312
XP_006725516                                                           17    4312
XP_005276858                                                           17    4312
XP_005276857                                                           17    4312
XP_006726285                                                           17    4312
XP_006726284                                                           17    4312
XP_006726283                                                           17    4312
XP_006726282                                                           17    4312
XP_006714693                                                           17    4312
XP_005248580                                                           17    4312
XP_006714692                                                           17    4312
XP_006714691                                                           17    4312
XP_006714690                                                           17    4312
XP_006714689                                                           17    4312
NP_003346                                                              16    7355
NP_001139681                                                           16    7355
NP_001230713                                                           16    7355
NP_001137311                                                           16    7355
NP_002590                                                              16    7355
XP_005274097                                                           16    7355
NP_001278017                                                           15    9605
NP_114157                                                              15    9605
NP_997191                                                              15    9605
NP_001013725                                                           15    9605
NP_001258558                                                           15    9605
NP_005911                                                              15    9605
NP_001152956                                                           15    9605
NP_056083                                                              15    9605
NP_057582                                                              15    9605
XP_006723474                                                           15    9605
XP_005259362                                                           15    9605
XP_005254450                                                           15    9605
XP_005254449                                                           15    9605
XP_005247302                                                           15    9605
XP_006711682                                                           15    9605
XP_006711396                                                           15    9605
XP_005245226                                                           15    9605
XP_005245227                                                           15    9605
XP_006711394                                                           15    9605
XP_006711393                                                           15    9605
>NP_065681
          Length = 1072

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VRRYTSTVL 9
           VRRYTST+L
Sbjct: 311 VRRYTSTLL 319
>NP_066124
          Length = 1114

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VRRYTSTVL 9
           VRRYTST+L
Sbjct: 311 VRRYTSTLL 319
>XP_006717999
          Length = 1207

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VRRYTSTVL 9
           VRRYTST+L
Sbjct: 404 VRRYTSTLL 412
>NP_004527
          Length = 1403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 589 IRRYLETIL 597
>NP_075043
          Length = 1241

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 427 IRRYLETIL 435
>XP_006725521
          Length = 792

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 589 IRRYLETIL 597
>XP_006725520
          Length = 1015

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 201 IRRYLETIL 209
>XP_006725519
          Length = 1139

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 325 IRRYLETIL 333
>XP_006725518
          Length = 1219

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 405 IRRYLETIL 413
>XP_006725517
          Length = 1348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 589 IRRYLETIL 597
>XP_006725516
          Length = 1352

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 589 IRRYLETIL 597
>XP_005276858
          Length = 792

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 589 IRRYLETIL 597
>XP_005276857
          Length = 1015

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 201 IRRYLETIL 209
>XP_006726285
          Length = 1139

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 325 IRRYLETIL 333
>XP_006726284
          Length = 1219

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 405 IRRYLETIL 413
>XP_006726283
          Length = 1348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 589 IRRYLETIL 597
>XP_006726282
          Length = 1352

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 589 IRRYLETIL 597
>XP_006714693
          Length = 792

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 589 IRRYLETIL 597
>XP_005248580
          Length = 1015

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 201 IRRYLETIL 209
>XP_006714692
          Length = 1139

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 325 IRRYLETIL 333
>XP_006714691
          Length = 1219

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 405 IRRYLETIL 413
>XP_006714690
          Length = 1348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 589 IRRYLETIL 597
>XP_006714689
          Length = 1352

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRRYTSTVL 9
           +RRY  T+L
Sbjct: 589 IRRYLETIL 597
>NP_003346
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRYTSTV 8
           RRY STV
Sbjct: 154 RRYQSTV 160
>NP_001139681
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YTSTVL 9
           YTSTVL
Sbjct: 363 YTSTVL 368
>NP_001230713
          Length = 920

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YTSTVL 9
           YTSTVL
Sbjct: 351 YTSTVL 356
>NP_001137311
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YTSTVL 9
           YTSTVL
Sbjct: 365 YTSTVL 370
>NP_002590
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YTSTVL 9
           YTSTVL
Sbjct: 372 YTSTVL 377
>XP_005274097
          Length = 940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YTSTVL 9
           YTSTVL
Sbjct: 371 YTSTVL 376
>NP_001278017
          Length = 2912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VRRYTST 7
           V+R+TST
Sbjct: 232 VKRFTST 238
>NP_114157
          Length = 2873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VRRYTST 7
           V+R+TST
Sbjct: 193 VKRFTST 199
>NP_997191
          Length = 1888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    RRYTST 7
            R+YTST
Sbjct: 1070 RKYTST 1075
>NP_001013725
          Length = 1649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRRYTSTVL 9
           +RRYT+ +L
Sbjct: 402 LRRYTAQLL 410
>NP_001258558
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRYTSTV 8
           RRY STV
Sbjct: 129 RRYGSTV 135
>NP_005911
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRYTSTV 8
           RRY STV
Sbjct: 129 RRYGSTV 135
>NP_001152956
          Length = 1736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    RRYTST 7
            R+YTST
Sbjct: 1070 RKYTST 1075
>NP_056083
          Length = 2243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VRRYTST 7
           VR+Y+ST
Sbjct: 303 VRKYSST 309
>NP_057582
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRRYTSTVL 9
           VR++T+T L
Sbjct: 121 VRKWTTTAL 129
>XP_006723474
          Length = 2737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VRRYTST 7
           V+R+TST
Sbjct: 232 VKRFTST 238
>XP_005259362
          Length = 2855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VRRYTST 7
           V+R+TST
Sbjct: 175 VKRFTST 181
>XP_005254450
          Length = 1505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRRYTSTVL 9
           +RRYT+ +L
Sbjct: 402 LRRYTAQLL 410
>XP_005254449
          Length = 1626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRRYTSTVL 9
           +RRYT+ +L
Sbjct: 402 LRRYTAQLL 410
>XP_005247302
          Length = 2248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VRRYTST 7
           VR+Y+ST
Sbjct: 303 VRKYSST 309
>XP_006711682
          Length = 1739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RRYTST 7
           R+YTST
Sbjct: 921 RKYTST 926
>XP_006711396
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRYTSTV 8
           RRY STV
Sbjct: 129 RRYGSTV 135
>XP_005245226
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRYTSTV 8
           RRY STV
Sbjct: 129 RRYGSTV 135
>XP_005245227
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRYTSTV 8
           RRY STV
Sbjct: 129 RRYGSTV 135
>XP_006711394
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRYTSTV 8
           RRY STV
Sbjct: 129 RRYGSTV 135
>XP_006711393
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRYTSTV 8
           RRY STV
Sbjct: 129 RRYGSTV 135
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.133    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 421,244
Number of extensions: 519
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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