Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001257436                                                           18    1135
NP_001257437                                                           18    1135
NP_006281                                                              18    1135
XP_005267176                                                           18    1135
NP_001735                                                              16    7355
NP_003909                                                              15    9605
NP_001171632                                                           15    9605
NP_001073324                                                           15    9605
NP_001171631                                                           15    9605
NP_115646                                                              15    9605
NP_065816                                                              15    9605
NP_004749                                                              15    9605
NP_077729                                                              15    9605
NP_001248764                                                           15    9605
XP_005274679                                                           15    9605
XP_005274678                                                           15    9605
XP_006724585                                                           15    9605
XP_006724584                                                           15    9605
XP_005274676                                                           15    9605
XP_005274674                                                           15    9605
XP_005274675                                                           15    9605
XP_006722241                                                           15    9605
XP_006722240                                                           15    9605
XP_006722238                                                           15    9605
XP_005257864                                                           15    9605
XP_006722237                                                           15    9605
XP_006722236                                                           15    9605
XP_006711023                                                           15    9605
XP_006710573                                                           15    9605
XP_006710572                                                           15    9605
XP_006710571                                                           15    9605
XP_006710570                                                           15    9605
XP_006710569                                                           15    9605
XP_006710568                                                           15    9605
XP_006710567                                                           15    9605
XP_006710566                                                           15    9605
XP_005245859                                                           15    9605

>NP_001257436
          Length = 790

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VRKLVVLKT 9
          VRKLV LKT
Sbjct: 89 VRKLVALKT 97



>NP_001257437
          Length = 790

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VRKLVVLKT 9
          VRKLV LKT
Sbjct: 89 VRKLVALKT 97



>NP_006281
          Length = 790

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VRKLVVLKT 9
          VRKLV LKT
Sbjct: 89 VRKLVALKT 97



>XP_005267176
          Length = 790

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VRKLVVLKT 9
          VRKLV LKT
Sbjct: 89 VRKLVALKT 97



>NP_001735
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VRKLVVL 7
           VRKL+VL
Sbjct: 277 VRKLIVL 283



>NP_003909
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RKLVVLKT 9
          RKLVVL T
Sbjct: 66 RKLVVLIT 73



>NP_001171632
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RKLVVLKT 9
          RKLVVL T
Sbjct: 66 RKLVVLIT 73



>NP_001073324
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RKLVVLKT 9
          RKLVVL T
Sbjct: 35 RKLVVLIT 42



>NP_001171631
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RKLVVLKT 9
          RKLVVL T
Sbjct: 35 RKLVVLIT 42



>NP_115646
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VRKLVVLK 8
           +RKL VLK
Sbjct: 636 LRKLTVLK 643



>NP_065816
          Length = 5183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VRKLVVLKT 9
            +RKLVV +T
Sbjct: 4273 LRKLVVQRT 4281



>NP_004749
          Length = 1857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKLVVLK 8
           R+LVVLK
Sbjct: 795 RRLVVLK 801



>NP_077729
          Length = 1797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKLVVLK 8
           R+LVVLK
Sbjct: 735 RRLVVLK 741



>NP_001248764
          Length = 1848

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKLVVLK 8
           R+LVVLK
Sbjct: 795 RRLVVLK 801



>XP_005274679
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RKLVVLKT 9
          RKLVVL T
Sbjct: 35 RKLVVLIT 42



>XP_005274678
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RKLVVLKT 9
          RKLVVL T
Sbjct: 35 RKLVVLIT 42



>XP_006724585
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RKLVVLKT 9
          RKLVVL T
Sbjct: 64 RKLVVLIT 71



>XP_006724584
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RKLVVLKT 9
          RKLVVL T
Sbjct: 66 RKLVVLIT 73



>XP_005274676
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RKLVVLKT 9
          RKLVVL T
Sbjct: 66 RKLVVLIT 73



>XP_005274674
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RKLVVLKT 9
          RKLVVL T
Sbjct: 66 RKLVVLIT 73



>XP_005274675
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RKLVVLKT 9
          RKLVVL T
Sbjct: 66 RKLVVLIT 73



>XP_006722241
          Length = 1467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKLVVLK 8
           R+LVVLK
Sbjct: 355 RRLVVLK 361



>XP_006722240
          Length = 1467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKLVVLK 8
           R+LVVLK
Sbjct: 355 RRLVVLK 361



>XP_006722238
          Length = 1847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKLVVLK 8
           R+LVVLK
Sbjct: 735 RRLVVLK 741



>XP_005257864
          Length = 1898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKLVVLK 8
           R+LVVLK
Sbjct: 795 RRLVVLK 801



>XP_006722237
          Length = 1900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKLVVLK 8
           R+LVVLK
Sbjct: 788 RRLVVLK 794



>XP_006722236
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKLVVLK 8
           R+LVVLK
Sbjct: 795 RRLVVLK 801



>XP_006711023
          Length = 808

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VRKLVVLK 8
           +RKL VLK
Sbjct: 641 LRKLTVLK 648



>XP_006710573
          Length = 5177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VRKLVVLKT 9
            +RKLVV +T
Sbjct: 4267 LRKLVVQRT 4275



>XP_006710572
          Length = 5188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VRKLVVLKT 9
            +RKLVV +T
Sbjct: 4278 LRKLVVQRT 4286



>XP_006710571
          Length = 5194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VRKLVVLKT 9
            +RKLVV +T
Sbjct: 4284 LRKLVVQRT 4292



>XP_006710570
          Length = 5195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VRKLVVLKT 9
            +RKLVV +T
Sbjct: 4285 LRKLVVQRT 4293



>XP_006710569
          Length = 5212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VRKLVVLKT 9
            +RKLVV +T
Sbjct: 4302 LRKLVVQRT 4310



>XP_006710568
          Length = 5221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VRKLVVLKT 9
            +RKLVV +T
Sbjct: 4311 LRKLVVQRT 4319



>XP_006710567
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VRKLVVLKT 9
            +RKLVV +T
Sbjct: 4312 LRKLVVQRT 4320



>XP_006710566
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VRKLVVLKT 9
            +RKLVV +T
Sbjct: 4312 LRKLVVQRT 4320



>XP_005245859
          Length = 5223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VRKLVVLKT 9
            +RKLVV +T
Sbjct: 4313 LRKLVVQRT 4321



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.144    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 328,068
Number of extensions: 483
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)