Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001128523                                                           18    1482
NP_065991                                                              18    1482
NP_891992                                                              17    3301
NP_570115                                                              17    4312
NP_056475                                                              17    4312
NP_079239                                                              17    4312
NP_001139681                                                           17    4312
NP_001230713                                                           17    4312
NP_001137311                                                           17    4312
NP_002590                                                              17    4312
NP_001243496                                                           17    4312
NP_000691                                                              17    4312
NP_000741                                                              17    4312
NP_001138740                                                           17    4312
NP_542141                                                              17    4312
NP_112598                                                              17    4312
XP_005260338                                                           17    4312
XP_005274097                                                           17    4312
XP_006715959                                                           17    4312
XP_005249911                                                           17    4312
XP_005249910                                                           17    4312
NP_001005479                                                           17    4312
NP_001245308                                                           16    5631
NP_001257436                                                           16    5631
NP_003606                                                              16    5631
NP_001245309                                                           16    5631
NP_001257437                                                           16    5631
NP_006281                                                              16    5631
NP_056009                                                              16    5631
NP_005679                                                              16    5631
NP_061738                                                              16    5631
NP_114398                                                              16    5631
XP_005258187                                                           16    5631
XP_005267176                                                           16    5631
XP_005247116                                                           16    5631
XP_005247115                                                           16    5631
XP_005265658                                                           16    5631
XP_005265657                                                           16    5631
XP_005265656                                                           16    5631
XP_005265655                                                           16    5631
XP_006713484                                                           16    5631
NP_001073678                                                           16    5631
NP_037365                                                              16    7355
NP_005100                                                              16    7355
NP_689607                                                              16    7355
XP_005247176                                                           16    7355
XP_006713561                                                           16    7355
XP_005265695                                                           16    7355
XP_005246523                                                           16    7355
XP_005246522                                                           16    7355
NP_001238892                                                           15    9605
NP_060661                                                              15    9605
NP_005992                                                              15    9605
NP_002449                                                              15    9605
NP_001238891                                                           15    9605
NP_057043                                                              15    9605
NP_525125                                                              15    9605
NP_056410                                                              15    9605
NP_005754                                                              15    9605
NP_004362                                                              15    9605
NP_001091868                                                           15    9605
NP_006553                                                              15    9605
NP_002680                                                              15    9605
NP_001009905                                                           15    9605
NP_997195                                                              15    9605
NP_001137484                                                           15    9605
XP_006726603                                                           15    9605
XP_006725352                                                           15    9605
XP_006725215                                                           15    9605
XP_005247381                                                           15    9605
XP_006725061                                                           15    9605
XP_006722336                                                           15    9605
XP_006722335                                                           15    9605
XP_005266498                                                           15    9605
XP_006719237                                                           15    9605
XP_005269500                                                           15    9605
>NP_001128523
          Length = 738

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VRKLVALCG 9
           V+KL+ LCG
Sbjct: 132 VQKLIRLCG 140
>NP_065991
          Length = 765

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VRKLVALCG 9
           V+KL+ LCG
Sbjct: 132 VQKLIRLCG 140
>NP_891992
          Length = 580

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VRKLVALCG 9
          +RK++A CG
Sbjct: 16 IRKVLAKCG 24
>NP_570115
          Length = 306

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VRKLVALCG 9
           +R+LVA CG
Sbjct: 174 LRELVAECG 182
>NP_056475
          Length = 337

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KLVALCG 9
           KLVA CG
Sbjct: 170 KLVAACG 176
>NP_079239
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RKLVALC 8
          RKL ALC
Sbjct: 57 RKLAALC 63
>NP_001139681
          Length = 932

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RKLVALCG 9
           RK++ LCG
Sbjct: 219 RKILQLCG 226
>NP_001230713
          Length = 920

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RKLVALCG 9
           RK++ LCG
Sbjct: 207 RKILQLCG 214
>NP_001137311
          Length = 934

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RKLVALCG 9
           RK++ LCG
Sbjct: 221 RKILQLCG 228
>NP_002590
          Length = 941

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RKLVALCG 9
           RK++ LCG
Sbjct: 228 RKILQLCG 235
>NP_001243496
          Length = 231

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LVALCG 9
          LVALCG
Sbjct: 12 LVALCG 17
>NP_000691
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LVALCG 9
           LVALCG
Sbjct: 339 LVALCG 344
>NP_000741
          Length = 498

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LVALCG 9
          LVALCG
Sbjct: 12 LVALCG 17
>NP_001138740
          Length = 392

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKLVALCG 9
           R LVA+CG
Sbjct: 100 RVLVAVCG 107
>NP_542141
          Length = 249

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KLVALCG 9
          KLV LCG
Sbjct: 6  KLVLLCG 12
>NP_112598
          Length = 5088

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    RKLVALC 8
            R+LVALC
Sbjct: 1484 RELVALC 1490
>XP_005260338
          Length = 249

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KLVALCG 9
          KLV LCG
Sbjct: 6  KLVLLCG 12
>XP_005274097
          Length = 940

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RKLVALCG 9
           RK++ LCG
Sbjct: 227 RKILQLCG 234
>XP_006715959
          Length = 385

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKLVALCG 9
           R LVA+CG
Sbjct: 100 RVLVAVCG 107
>XP_005249911
          Length = 672

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RKLVALC 8
          RKL ALC
Sbjct: 57 RKLAALC 63
>XP_005249910
          Length = 801

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RKLVALC 8
          RKL ALC
Sbjct: 57 RKLAALC 63
>NP_001005479
          Length = 325

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRKLVALCG 9
           +RK V+ CG
Sbjct: 250 IRKAVSTCG 258
>NP_001245308
          Length = 1131

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VRKLVALC 8
            VRKL+ LC
Sbjct: 999  VRKLMDLC 1006
>NP_001257436
          Length = 790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  VRKLVAL 7
          VRKLVAL
Sbjct: 89 VRKLVAL 95
>NP_003606
          Length = 1214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VRKLVALC 8
            VRKL+ LC
Sbjct: 1118 VRKLMDLC 1125
>NP_001245309
          Length = 1090

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VRKLVALC 8
            VRKL+ LC
Sbjct: 994  VRKLMDLC 1001
>NP_001257437
          Length = 790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  VRKLVAL 7
          VRKLVAL
Sbjct: 89 VRKLVAL 95
>NP_006281
          Length = 790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  VRKLVAL 7
          VRKLVAL
Sbjct: 89 VRKLVAL 95
>NP_056009
          Length = 1006

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRKLVALCG 9
           V+KL+  CG
Sbjct: 659 VKKLIERCG 667
>NP_005679
          Length = 1437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KLVALCG 9
           KLV +CG
Sbjct: 589 KLVGICG 595
>NP_061738
          Length = 932

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RKLVALC 8
          RKLV LC
Sbjct: 11 RKLVLLC 17
>NP_114398
          Length = 823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  RKLVALC 8
          RKLV LC
Sbjct: 11 RKLVLLC 17
>XP_005258187
          Length = 621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LVALCG 9
          L+ALCG
Sbjct: 54 LIALCG 59
>XP_005267176
          Length = 790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  VRKLVAL 7
          VRKLVAL
Sbjct: 89 VRKLVAL 95
>XP_005247116
          Length = 1437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KLVALCG 9
           KLV +CG
Sbjct: 589 KLVGICG 595
>XP_005247115
          Length = 1437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KLVALCG 9
           KLV +CG
Sbjct: 589 KLVGICG 595
>XP_005265658
          Length = 1095

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VRKLVALC 8
            VRKL+ LC
Sbjct: 999  VRKLMDLC 1006
>XP_005265657
          Length = 1113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VRKLVALC 8
           VRKL+ LC
Sbjct: 981 VRKLMDLC 988
>XP_005265656
          Length = 1118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VRKLVALC 8
           VRKL+ LC
Sbjct: 986 VRKLMDLC 993
>XP_005265655
          Length = 1126

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VRKLVALC 8
            VRKL+ LC
Sbjct: 994  VRKLMDLC 1001
>XP_006713484
          Length = 1255

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VRKLVALC 8
            VRKL+ LC
Sbjct: 1123 VRKLMDLC 1130
>NP_001073678
          Length = 621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LVALCG 9
          L+ALCG
Sbjct: 54 LIALCG 59
>NP_037365
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RKLVALC 8
           RKL++LC
Sbjct: 311 RKLLSLC 317
>NP_005100
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   RKLVALC 8
           RK+++LC
Sbjct: 265 RKMISLC 271
>NP_689607
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KLVALC 8
           KL+ALC
Sbjct: 637 KLIALC 642
>XP_005247176
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KLVALC 8
           KL+ALC
Sbjct: 491 KLIALC 496
>XP_006713561
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KLVALC 8
           KL+ALC
Sbjct: 590 KLIALC 595
>XP_005265695
          Length = 460

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   RKLVALC 8
           RK+++LC
Sbjct: 198 RKMISLC 204
>XP_005246523
          Length = 381

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RKLVALC 8
           RKL++LC
Sbjct: 147 RKLLSLC 153
>XP_005246522
          Length = 524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RKLVALC 8
           RKL++LC
Sbjct: 311 RKLLSLC 317
>NP_001238892
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VRKLVALC 8
           V KLV LC
Sbjct: 613 VSKLVRLC 620
>NP_060661
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  RKLVALCG 9
          +KL  LCG
Sbjct: 66 KKLEGLCG 73
>NP_005992
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VRKLVALC 8
           +RKL  LC
Sbjct: 122 IRKLADLC 129
>NP_002449
          Length = 5762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    LVALCG 9
            L+A+CG
Sbjct: 1285 LIAICG 1290
>NP_001238891
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VRKLVALC 8
           V KLV LC
Sbjct: 613 VSKLVRLC 620
>NP_057043
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  VRKLVALC 8
          VRKL  LC
Sbjct: 39 VRKLPPLC 46
>NP_525125
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VRKLVALC 8
           +RKL  LC
Sbjct: 122 IRKLADLC 129
>NP_056410
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VRKLVALC 8
           V KLV LC
Sbjct: 613 VSKLVRLC 620
>NP_005754
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KLVALC 8
           KLVA+C
Sbjct: 348 KLVAIC 353
>NP_004362
          Length = 1224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RKLVALC 8
           RKL ALC
Sbjct: 516 RKLDALC 522
>NP_001091868
          Length = 1233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RKLVALC 8
           RKL ALC
Sbjct: 525 RKLDALC 531
>NP_006553
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VRKLVALCG 9
          VR+  +LCG
Sbjct: 47 VRRSYSLCG 55
>NP_002680
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  VRKLVALC 8
          + KLV LC
Sbjct: 24 IEKLVELC 31
>NP_001009905
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RKLVALC 8
           RK+VA C
Sbjct: 286 RKVVAFC 292
>NP_997195
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VRKLVALC 8
           +RKL  LC
Sbjct: 122 IRKLADLC 129
>NP_001137484
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  VRKLVALC 8
          VRKL  LC
Sbjct: 39 VRKLPPLC 46
>XP_006726603
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    LVALCG 9
            L+A+CG
Sbjct: 1059 LIAICG 1064
>XP_006725352
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RKLVALC 8
           RK+VA C
Sbjct: 271 RKVVAFC 277
>XP_006725215
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    LVALCG 9
            L+A+CG
Sbjct: 1059 LIAICG 1064
>XP_005247381
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VRKLVALC 8
           V KLV LC
Sbjct: 118 VSKLVRLC 125
>XP_006725061
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VRKLVALC 8
           V KLV LC
Sbjct: 646 VSKLVRLC 653
>XP_006722336
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RKLVALC 8
           RK+VA C
Sbjct: 271 RKVVAFC 277
>XP_006722335
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RKLVALC 8
           RK+VA C
Sbjct: 286 RKVVAFC 292
>XP_005266498
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  RKLVALCG 9
          +KL  LCG
Sbjct: 66 KKLEGLCG 73
>XP_006719237
          Length = 1263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    LVALCG 9
            L+A+CG
Sbjct: 1059 LIAICG 1064
>XP_005269500
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VRKLVALCG 9
          VR+  +LCG
Sbjct: 47 VRRSYSLCG 55
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.150    0.473 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 537,001
Number of extensions: 825
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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