Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              18    1135
NP_001087241                                                           18    1135
XP_005265799                                                           18    1135
XP_005265798                                                           18    1135
XP_005265797                                                           18    1135
NP_064716                                                              17    3301
NP_057006                                                              17    4312
NP_001123237                                                           17    4312
NP_940912                                                              17    4312
XP_006724887                                                           17    4312
NP_001747                                                              16    5631
NP_005494                                                              16    7355
NP_001123886                                                           16    7355
NP_689758                                                              16    7355
NP_001154                                                              16    7355
NP_001265043                                                           16    7355
NP_001265042                                                           16    7355
NP_001455                                                              16    7355
XP_006725606                                                           16    7355
XP_005254388                                                           16    7355
XP_006725182                                                           16    7355
XP_006720544                                                           16    7355
XP_006720543                                                           16    7355
XP_005252025                                                           16    7355
XP_005252024                                                           16    7355
XP_006717156                                                           16    7355
XP_005273525                                                           16    7355
XP_005262834                                                           16    7355
XP_006714175                                                           16    7355
XP_005262833                                                           16    7355
NP_694984                                                              15    9605
NP_002026                                                              15    9605
NP_056127                                                              15    9605
NP_001035292                                                           15    9605
NP_001631                                                              15    9605
XP_005262172                                                           15    9605
XP_005262170                                                           15    9605
XP_006723172                                                           15    9605
XP_006723171                                                           15    9605
XP_006723167                                                           15    9605
XP_006723166                                                           15    9605
XP_006723165                                                           15    9605
XP_006723164                                                           15    9605
XP_006723163                                                           15    9605
XP_006723162                                                           15    9605
XP_006723161                                                           15    9605
XP_005266734                                                           15    9605
XP_006722496                                                           15    9605
XP_006714407                                                           15    9605
XP_006714405                                                           15    9605
XP_005263349                                                           15    9605
XP_005263348                                                           15    9605
XP_005263347                                                           15    9605
XP_005263346                                                           15    9605
XP_005263345                                                           15    9605
XP_005263344                                                           15    9605
XP_005263343                                                           15    9605
XP_005263342                                                           15    9605
XP_005263341                                                           15    9605
XP_005263340                                                           15    9605
XP_005263339                                                           15    9605
XP_006714167                                                           15    9605
XP_005265155                                                           15    9605
XP_005265154                                                           15    9605
NP_060689                                                              15    9605
>NP_000213
          Length = 976

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRINYVGST 9
           VRIN VGST
Sbjct: 955 VRINSVGST 963
>NP_001087241
          Length = 972

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRINYVGST 9
           VRIN VGST
Sbjct: 951 VRINSVGST 959
>XP_005265799
          Length = 973

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRINYVGST 9
           VRIN VGST
Sbjct: 952 VRINSVGST 960
>XP_005265798
          Length = 976

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRINYVGST 9
           VRIN VGST
Sbjct: 955 VRINSVGST 963
>XP_005265797
          Length = 977

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRINYVGST 9
           VRIN VGST
Sbjct: 956 VRINSVGST 964
>NP_064716
          Length = 578

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VRINYVG 7
           +RINY+G
Sbjct: 166 IRINYLG 172
>NP_057006
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   RINYVGS 8
           R+NY+G+
Sbjct: 119 RVNYIGT 125
>NP_001123237
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   RINYVGS 8
           R+NY+G+
Sbjct: 119 RVNYIGT 125
>NP_940912
          Length = 1313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VRINYVG 7
           VR+NY+G
Sbjct: 477 VRLNYLG 483
>XP_006724887
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   RINYVGS 8
           R+NY+G+
Sbjct: 119 RVNYIGT 125
>NP_001747
          Length = 405

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VRINYVGS 8
           V++NYVG+
Sbjct: 253 VQMNYVGN 260
>NP_005494
          Length = 749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NY+GST
Sbjct: 375 NYLGST 380
>NP_001123886
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NY+GST
Sbjct: 375 NYLGST 380
>NP_689758
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RINYVG 7
           R+NY+G
Sbjct: 220 RLNYIG 225
>NP_001154
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NY+GST
Sbjct: 464 NYLGST 469
>NP_001265043
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NYVG+T
Sbjct: 276 NYVGAT 281
>NP_001265042
          Length = 716

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NYVG+T
Sbjct: 257 NYVGAT 262
>NP_001455
          Length = 735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NYVG+T
Sbjct: 276 NYVGAT 281
>XP_006725606
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NY+GST
Sbjct: 375 NYLGST 380
>XP_005254388
          Length = 749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NY+GST
Sbjct: 375 NYLGST 380
>XP_006725182
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NYVG+T
Sbjct: 276 NYVGAT 281
>XP_006720544
          Length = 778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NY+GST
Sbjct: 375 NYLGST 380
>XP_006720543
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NY+GST
Sbjct: 375 NYLGST 380
>XP_005252025
          Length = 826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NY+GST
Sbjct: 464 NYLGST 469
>XP_005252024
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NY+GST
Sbjct: 464 NYLGST 469
>XP_006717156
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NY+GST
Sbjct: 464 NYLGST 469
>XP_005273525
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           NYVG+T
Sbjct: 276 NYVGAT 281
>XP_005262834
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RINYVG 7
           R+NY+G
Sbjct: 178 RLNYIG 183
>XP_006714175
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RINYVG 7
           R+NY+G
Sbjct: 179 RLNYIG 184
>XP_005262833
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   RINYVG 7
           R+NY+G
Sbjct: 219 RLNYIG 224
>NP_694984
          Length = 1802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VRINYVGS 8
           +RI Y+GS
Sbjct: 342 IRIYYLGS 349
>NP_002026
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   INYVGS 8
           INY+GS
Sbjct: 144 INYLGS 149
>NP_056127
          Length = 5005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 4504 RVDYMGSS 4511
>NP_001035292
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RINYVGST 9
           ++NY+GS+
Sbjct: 266 QLNYLGSS 273
>NP_001631
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   INYVGST 9
           +NY GST
Sbjct: 535 VNYRGST 541
>XP_005262172
          Length = 1631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VRINYVGS 8
           +RI Y+GS
Sbjct: 171 IRIYYLGS 178
>XP_005262170
          Length = 1752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VRINYVGS 8
           +RI Y+GS
Sbjct: 342 IRIYYLGS 349
>XP_006723172
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  INYVGST 9
          +NY+G T
Sbjct: 17 VNYLGGT 23
>XP_006723171
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  INYVGST 9
          +NY+G T
Sbjct: 41 VNYLGGT 47
>XP_006723167
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  INYVGST 9
          +NY+G T
Sbjct: 17 VNYLGGT 23
>XP_006723166
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  INYVGST 9
          +NY+G T
Sbjct: 17 VNYLGGT 23
>XP_006723165
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  INYVGST 9
          +NY+G T
Sbjct: 17 VNYLGGT 23
>XP_006723164
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  INYVGST 9
          +NY+G T
Sbjct: 17 VNYLGGT 23
>XP_006723163
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  INYVGST 9
          +NY+G T
Sbjct: 41 VNYLGGT 47
>XP_006723162
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  INYVGST 9
          +NY+G T
Sbjct: 41 VNYLGGT 47
>XP_006723161
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  INYVGST 9
          +NY+G T
Sbjct: 41 VNYLGGT 47
>XP_005266734
          Length = 298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   INYVGS 8
           INY+GS
Sbjct: 144 INYLGS 149
>XP_006722496
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   INYVGS 8
           INY+GS
Sbjct: 115 INYLGS 120
>XP_006714407
          Length = 5004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 4503 RVDYMGSS 4510
>XP_006714405
          Length = 4103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 3602 RVDYMGSS 3609
>XP_005263349
          Length = 4410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 3909 RVDYMGSS 3916
>XP_005263348
          Length = 4443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 3942 RVDYMGSS 3949
>XP_005263347
          Length = 4640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 4525 RVDYMGSS 4532
>XP_005263346
          Length = 4983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 4482 RVDYMGSS 4489
>XP_005263345
          Length = 4991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 4490 RVDYMGSS 4497
>XP_005263344
          Length = 5005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 4504 RVDYMGSS 4511
>XP_005263343
          Length = 5009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 4508 RVDYMGSS 4515
>XP_005263342
          Length = 5025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 4524 RVDYMGSS 4531
>XP_005263341
          Length = 5026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 4525 RVDYMGSS 4532
>XP_005263340
          Length = 5026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 4525 RVDYMGSS 4532
>XP_005263339
          Length = 5026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RINYVGST 9
            R++Y+GS+
Sbjct: 4525 RVDYMGSS 4532
>XP_006714167
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RINYVGST 9
           ++NY+GS+
Sbjct: 266 QLNYLGSS 273
>XP_005265155
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   INYVGST 9
           +NY GST
Sbjct: 434 VNYRGST 440
>XP_005265154
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   INYVGST 9
           +NY GST
Sbjct: 489 VNYRGST 495
>NP_060689
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   NYVGST 9
           N+VGST
Sbjct: 485 NFVGST 490
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.137    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 527,899
Number of extensions: 769
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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