Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001261                                                              21     175
XP_005271924                                                           21     175
XP_005271923                                                           21     175
NP_065861                                                              18    1935
XP_005267973                                                           18    1935
NP_001036037                                                           17    2528
NP_112211                                                              17    2528
NP_001262                                                              17    2528
XP_005267209                                                           17    2528
NP_444507                                                              17    4312
XP_006724088                                                           17    4312
NP_000161                                                              16    5631
NP_037535                                                              16    5631
NP_001034966                                                           16    5631
XP_006723237                                                           16    5631
XP_006723236                                                           16    5631
XP_006723235                                                           16    5631
XP_006723234                                                           16    5631
XP_005248127                                                           16    5631
XP_005248126                                                           16    5631
XP_005248125                                                           16    5631
XP_005248124                                                           16    5631
XP_005248123                                                           16    5631
XP_005248122                                                           16    5631
XP_005248121                                                           16    5631
XP_005248120                                                           16    5631
XP_006714059                                                           16    5631
XP_005248119                                                           16    5631
XP_005248118                                                           16    5631
XP_005248117                                                           16    5631
XP_005248116                                                           16    5631
XP_005248115                                                           16    5631
XP_005248114                                                           16    5631
NP_000072                                                              16    7355
NP_001068567                                                           16    7355
NP_003717                                                              16    7355
NP_525023                                                              16    7355
XP_005257813                                                           16    7355
XP_005257814                                                           16    7355
XP_005257812                                                           16    7355
XP_006721856                                                           16    7355
XP_006721855                                                           16    7355
XP_006721854                                                           16    7355
XP_006721853                                                           16    7355
XP_006711794                                                           16    7355
XP_005273086                                                           16    7355
XP_005273085                                                           16    7355
XP_005273084                                                           16    7355
NP_619634                                                              16    7355
NP_115495                                                              15    9605
NP_005989                                                              15    9605
NP_001008800                                                           15    9605
NP_055928                                                              15    9605
XP_005256618                                                           15    9605
XP_005256617                                                           15    9605
NP_001152967                                                           15    9605
>NP_001261
          Length = 1710

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VRGMRKLDN 9
           VRGM+KLDN
Sbjct: 343 VRGMKKLDN 351
>XP_005271924
          Length = 1710

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VRGMRKLDN 9
           VRGM+KLDN
Sbjct: 343 VRGMKKLDN 351
>XP_005271923
          Length = 1798

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VRGMRKLDN 9
           VRGM+KLDN
Sbjct: 343 VRGMKKLDN 351
>NP_065861
          Length = 509

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  VRGMRKLD 8
          VRGM KLD
Sbjct: 79 VRGMTKLD 86
>XP_005267973
          Length = 537

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VRGMRKLD 8
           VRGM KLD
Sbjct: 107 VRGMTKLD 114
>NP_001036037
          Length = 501

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VRGMRKLDN 9
           V+G++KL+N
Sbjct: 332 VKGLKKLEN 340
>NP_112211
          Length = 165

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VRGMRKL 7
           +RGMRKL
Sbjct: 151 IRGMRKL 157
>NP_001262
          Length = 1828

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VRGMRKLDN 9
           V+G++KL+N
Sbjct: 332 VKGLKKLEN 340
>XP_005267209
          Length = 108

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VRGMRKL 7
           +RGMRKL
Sbjct: 94  IRGMRKL 100
>NP_444507
          Length = 686

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++ +RKLDN
Sbjct: 579 LKALRKLDN 587
>XP_006724088
          Length = 646

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++ +RKLDN
Sbjct: 539 LKALRKLDN 547
>NP_000161
          Length = 1020

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           VR M+KL+N
Sbjct: 535 VRYMKKLEN 543
>NP_037535
          Length = 753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RGMRKLDN 9
           RG+R LDN
Sbjct: 659 RGIRFLDN 666
>NP_001034966
          Length = 760

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RGMRKLDN 9
           RG+R LDN
Sbjct: 666 RGIRFLDN 673
>XP_006723237
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RGMRKLDN 9
           RG+R LDN
Sbjct: 547 RGIRFLDN 554
>XP_006723236
          Length = 656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RGMRKLDN 9
           RG+R LDN
Sbjct: 562 RGIRFLDN 569
>XP_006723235
          Length = 768

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RGMRKLDN 9
           RG+R LDN
Sbjct: 674 RGIRFLDN 681
>XP_006723234
          Length = 775

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RGMRKLDN 9
           RG+R LDN
Sbjct: 681 RGIRFLDN 688
>XP_005248127
          Length = 1322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 799 LKGQRKLDD 807
>XP_005248126
          Length = 1359

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 528 LKGQRKLDD 536
>XP_005248125
          Length = 1439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 608 LKGQRKLDD 616
>XP_005248124
          Length = 1467

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 640 LKGQRKLDD 648
>XP_005248123
          Length = 1471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 640 LKGQRKLDD 648
>XP_005248122
          Length = 1471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 640 LKGQRKLDD 648
>XP_005248121
          Length = 1543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 712 LKGQRKLDD 720
>XP_005248120
          Length = 1549

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 718 LKGQRKLDD 726
>XP_006714059
          Length = 1600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 799 LKGQRKLDD 807
>XP_005248119
          Length = 1601

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 799 LKGQRKLDD 807
>XP_005248118
          Length = 1602

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 799 LKGQRKLDD 807
>XP_005248117
          Length = 1626

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 799 LKGQRKLDD 807
>XP_005248116
          Length = 1627

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 799 LKGQRKLDD 807
>XP_005248115
          Length = 1629

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 799 LKGQRKLDD 807
>XP_005248114
          Length = 1630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           ++G RKLD+
Sbjct: 799 LKGQRKLDD 807
>NP_000072
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VRGMRKLD 8
            +RGM K+D
Sbjct: 2909 IRGMYKVD 2916
>NP_001068567
          Length = 358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           V+G ++LDN
Sbjct: 99  VKGAQELDN 107
>NP_003717
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           V+G ++LDN
Sbjct: 99  VKGAQELDN 107
>NP_525023
          Length = 1617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VRGMRKLD 8
            V+G+RK D
Sbjct: 1381 VKGLRKAD 1388
>XP_005257813
          Length = 265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VRGMRKLDN 9
          V+G ++LDN
Sbjct: 5  VKGAQELDN 13
>XP_005257814
          Length = 265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VRGMRKLDN 9
          V+G ++LDN
Sbjct: 5  VKGAQELDN 13
>XP_005257812
          Length = 341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGMRKLDN 9
           V+G ++LDN
Sbjct: 99  VKGAQELDN 107
>XP_006721856
          Length = 1300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VRGMRKLD 8
            V+G+RK D
Sbjct: 1064 VKGLRKAD 1071
>XP_006721855
          Length = 1551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VRGMRKLD 8
            V+G+RK D
Sbjct: 1315 VKGLRKAD 1322
>XP_006721854
          Length = 1577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VRGMRKLD 8
            V+G+RK D
Sbjct: 1341 VKGLRKAD 1348
>XP_006721853
          Length = 1617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VRGMRKLD 8
            V+G+RK D
Sbjct: 1381 VKGLRKAD 1388
>XP_006711794
          Length = 3022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VRGMRKLD 8
            +RGM K+D
Sbjct: 2130 IRGMYKVD 2137
>XP_005273086
          Length = 3264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VRGMRKLD 8
            +RGM K+D
Sbjct: 2909 IRGMYKVD 2916
>XP_005273085
          Length = 3755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VRGMRKLD 8
            +RGM K+D
Sbjct: 2863 IRGMYKVD 2870
>XP_005273084
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VRGMRKLD 8
            +RGM K+D
Sbjct: 2909 IRGMYKVD 2916
>NP_619634
          Length = 147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VRGMRKL 7
           +RGM+KL
Sbjct: 135 IRGMQKL 141
>NP_115495
          Length = 6306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    VRGMRKLD 8
            +RG++K D
Sbjct: 5099 IRGLQKFD 5106
>NP_005989
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRGMRKLDN 9
           +R +RK DN
Sbjct: 312 IRRVRKTDN 320
>NP_001008800
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VRGMRKLDN 9
           +R +RK DN
Sbjct: 274 IRRVRKTDN 282
>NP_055928
          Length = 2961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    GMRKLD 8
            G+RKLD
Sbjct: 1075 GLRKLD 1080
>XP_005256618
          Length = 2962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    GMRKLD 8
            G+RKLD
Sbjct: 1076 GLRKLD 1081
>XP_005256617
          Length = 2966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    GMRKLD 8
            G+RKLD
Sbjct: 1076 GLRKLD 1081
>NP_001152967
          Length = 97

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  VRGMRKLDN 9
          +RG +++DN
Sbjct: 2  LRGTKEMDN 10
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.143    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 497,869
Number of extensions: 707
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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