Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_060009                                                              18    1135
XP_006721125                                                           18    1135
NP_115582                                                              17    2528
XP_006721363                                                           17    2528
XP_005256258                                                           17    2528
XP_005256257                                                           17    2528
XP_005256256                                                           17    2528
XP_005256255                                                           17    2528
XP_006721362                                                           17    2528
XP_006721361                                                           17    2528
XP_005256254                                                           17    2528
XP_005256253                                                           17    2528
XP_005256252                                                           17    2528
XP_005256251                                                           17    2528
XP_006721360                                                           17    2528
XP_005256250                                                           17    2528
NP_005119                                                              17    3301
XP_006724131                                                           17    3301
NP_000876                                                              17    4312
XP_005271739                                                           17    4312
NP_003469                                                              17    4312
NP_000760                                                              16    5631
NP_000454                                                              16    5631
NP_000762                                                              16    5631
XP_006717707                                                           16    5631
NP_055141                                                              16    7355
NP_005480                                                              16    7355
NP_001239263                                                           16    7355
NP_001136005                                                           16    7355
NP_733745                                                              16    7355
NP_001136006                                                           16    7355
NP_055073                                                              16    7355
XP_006723744                                                           16    7355
XP_005260304                                                           16    7355
XP_005254325                                                           16    7355
XP_006720513                                                           16    7355
XP_006720512                                                           16    7355
XP_005251694                                                           16    7355
NP_000161                                                              15    9605
NP_001340                                                              15    9605
NP_002363                                                              15    9605
NP_006112                                                              15    9605
XP_006714679                                                           15    9605
XP_005248188                                                           15    9605
XP_005264214                                                           15    9605
NP_689729                                                              15    9605
>NP_060009
          Length = 4116

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VR SL+NLG
Sbjct: 3890 VRRSLINLG 3898
>XP_006721125
          Length = 4070

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VR SL+NLG
Sbjct: 3844 VRRSLINLG 3852
>NP_115582
          Length = 1866

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1301 VREASVNLG 1309
>XP_006721363
          Length = 1385

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1301 VREASVNLG 1309
>XP_005256258
          Length = 1397

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1270 VREASVNLG 1278
>XP_005256257
          Length = 1405

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1301 VREASVNLG 1309
>XP_005256256
          Length = 1427

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1300 VREASVNLG 1308
>XP_005256255
          Length = 1809

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1244 VREASVNLG 1252
>XP_006721362
          Length = 1810

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1301 VREASVNLG 1309
>XP_006721361
          Length = 1836

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1271 VREASVNLG 1279
>XP_005256254
          Length = 1837

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1272 VREASVNLG 1280
>XP_005256253
          Length = 1838

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1273 VREASVNLG 1281
>XP_005256252
          Length = 1865

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1300 VREASVNLG 1308
>XP_005256251
          Length = 1866

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1301 VREASVNLG 1309
>XP_006721360
          Length = 1866

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1301 VREASVNLG 1309
>XP_005256250
          Length = 1866

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VRESLVNLG 9
            VRE+ VNLG
Sbjct: 1301 VREASVNLG 1309
>NP_005119
          Length = 2298

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ESLVNLG 9
            ESL+NLG
Sbjct: 1421 ESLINLG 1427
>XP_006724131
          Length = 2298

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ESLVNLG 9
            ESL+NLG
Sbjct: 1421 ESLINLG 1427
>NP_000876
          Length = 1032

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESLVNLG 9
           ES+VNLG
Sbjct: 370 ESIVNLG 376
>XP_005271739
          Length = 721

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VRESLVNL 8
           VRES VNL
Sbjct: 121 VRESYVNL 128
>NP_003469
          Length = 780

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VRESLVNL 8
           VRES VNL
Sbjct: 180 VRESYVNL 187
>NP_000760
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  VRESLVNLG 9
          V+E+L++LG
Sbjct: 83 VKEALIDLG 91
>NP_000454
          Length = 533

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VRESLVNLG 9
          V+ES V+LG
Sbjct: 88 VKESFVSLG 96
>NP_000762
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  VRESLVNLG 9
          V+E+L++LG
Sbjct: 83 VKEALIDLG 91
>XP_006717707
          Length = 277

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  VRESLVNLG 9
          V+E+L++LG
Sbjct: 83 VKEALIDLG 91
>NP_055141
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RESLVNL 8
           RES+VNL
Sbjct: 297 RESVVNL 303
>NP_005480
          Length = 703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VRESLVNLG 9
          +R+SL +LG
Sbjct: 85 IRDSLTSLG 93
>NP_001239263
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRESLVNLG 9
           +R+SL +LG
Sbjct: 174 IRDSLTSLG 182
>NP_001136005
          Length = 702

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VRESLVNLG 9
          +R+SL +LG
Sbjct: 84 IRDSLTSLG 92
>NP_733745
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRESLVNLG 9
           +R+SL +LG
Sbjct: 242 IRDSLTSLG 250
>NP_001136006
          Length = 700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VRESLVNLG 9
          +R+SL +LG
Sbjct: 82 IRDSLTSLG 90
>NP_055073
          Length = 1530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRESLVNLG 9
           ++ESL+N G
Sbjct: 824 LKESLINSG 832
>XP_006723744
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRESLVNLG 9
           ++ESL+N G
Sbjct: 824 LKESLINSG 832
>XP_005260304
          Length = 1530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRESLVNLG 9
           ++ESL+N G
Sbjct: 824 LKESLINSG 832
>XP_005254325
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RESLVNL 8
           RES+VNL
Sbjct: 300 RESVVNL 306
>XP_006720513
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RESLVNL 8
           RES+VNL
Sbjct: 300 RESVVNL 306
>XP_006720512
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RESLVNL 8
           RES+VNL
Sbjct: 300 RESVVNL 306
>XP_005251694
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRESLVNLG 9
           +R+SL +LG
Sbjct: 204 IRDSLTSLG 212
>NP_000161
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VRESLVNL 8
           VRESLV +
Sbjct: 336 VRESLVRM 343
>NP_001340
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RESLVNLG 9
           RE+L+N G
Sbjct: 207 RETLINKG 214
>NP_002363
          Length = 1144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  VRESLVNL 8
          +R+S++NL
Sbjct: 72 IRDSVINL 79
>NP_006112
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SLVNLG 9
          SLVNLG
Sbjct: 66 SLVNLG 71
>XP_006714679
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  VRESLVNL 8
          +R+S++NL
Sbjct: 72 IRDSVINL 79
>XP_005248188
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RESLVNLG 9
          +ESL NLG
Sbjct: 6  KESLGNLG 13
>XP_005264214
          Length = 124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VRESLVN 7
          +RESL+N
Sbjct: 39 IRESLMN 45
>NP_689729
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VRESLVN 7
           +RESL+N
Sbjct: 105 IRESLMN 111
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.138    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 408,260
Number of extensions: 890
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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