Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              20     509
NP_001263689                                                           20     509
NP_001119584                                                           20     509
NP_001119586                                                           20     509
NP_001263625                                                           20     509
NP_001119590                                                           20     509
NP_001263690                                                           20     509
NP_001119585                                                           20     509
NP_001263624                                                           20     509
NP_001119588                                                           20     509
NP_001119587                                                           20     509
NP_001119589                                                           20     509
NP_001108451                                                           17    3301
NP_001108454                                                           17    3301
NP_003713                                                              17    3301
NP_001108450                                                           17    3301
NP_001108452                                                           17    3301
NP_001108453                                                           17    3301
NP_001191121                                                           17    3301
NP_001119713                                                           17    3301
NP_001191117                                                           17    3301
NP_001119712                                                           17    3301
NP_001119714                                                           17    3301
NP_005418                                                              17    3301
NP_001191116                                                           17    3301
NP_001191115                                                           17    3301
NP_001191119                                                           17    3301
NP_001191113                                                           17    3301
NP_001191118                                                           17    3301
NP_001191120                                                           17    3301
NP_001191114                                                           17    3301
NP_612350                                                              17    3301
NP_001180382                                                           17    3301
NP_001180460                                                           17    3301
XP_006719743                                                           17    3301
XP_006719742                                                           17    3301
XP_006719741                                                           17    3301
XP_005254043                                                           17    3301
XP_005254042                                                           17    3301
XP_005247903                                                           17    3301
XP_005247901                                                           17    3301
XP_005247900                                                           17    3301
NP_055448                                                              17    3301
NP_001008844                                                           16    7355
NP_004406                                                              16    7355
NP_061923                                                              16    7355
XP_005263135                                                           16    7355
XP_005263134                                                           16    7355
XP_006714303                                                           16    7355
XP_005263133                                                           16    7355
XP_005263132                                                           16    7355
XP_005263131                                                           16    7355
XP_005263130                                                           16    7355
NP_061982                                                              15    9605
NP_001013758                                                           15    9605
XP_005255488                                                           15    9605
>NP_000537
          Length = 393

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           VRAM IYKQ
Sbjct: 157 VRAMAIYKQ 165
>NP_001263689
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           VRAM IYKQ
Sbjct: 118 VRAMAIYKQ 126
>NP_001119584
          Length = 393

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           VRAM IYKQ
Sbjct: 157 VRAMAIYKQ 165
>NP_001119586
          Length = 341

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           VRAM IYKQ
Sbjct: 157 VRAMAIYKQ 165
>NP_001263625
          Length = 302

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           VRAM IYKQ
Sbjct: 118 VRAMAIYKQ 126
>NP_001119590
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           VRAM IYKQ
Sbjct: 118 VRAMAIYKQ 126
>NP_001263690
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           VRAM IYKQ
Sbjct: 118 VRAMAIYKQ 126
>NP_001119585
          Length = 346

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           VRAM IYKQ
Sbjct: 157 VRAMAIYKQ 165
>NP_001263624
          Length = 307

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           VRAM IYKQ
Sbjct: 118 VRAMAIYKQ 126
>NP_001119588
          Length = 209

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VRAMTIYKQ 9
          VRAM IYKQ
Sbjct: 25 VRAMAIYKQ 33
>NP_001119587
          Length = 261

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VRAMTIYKQ 9
          VRAM IYKQ
Sbjct: 25 VRAMAIYKQ 33
>NP_001119589
          Length = 214

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VRAMTIYKQ 9
          VRAM IYKQ
Sbjct: 25 VRAMAIYKQ 33
>NP_001108451
          Length = 487

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 225 IRAMPVYKK 233
>NP_001108454
          Length = 393

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 131 IRAMPVYKK 139
>NP_003713
          Length = 680

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 225 IRAMPVYKK 233
>NP_001108450
          Length = 555

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 225 IRAMPVYKK 233
>NP_001108452
          Length = 586

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 131 IRAMPVYKK 139
>NP_001108453
          Length = 461

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 131 IRAMPVYKK 139
>NP_001191121
          Length = 565

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 104 IRAMPVYKK 112
>NP_001119713
          Length = 450

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 126 IRAMPVYKK 134
>NP_001191117
          Length = 540

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 175 IRAMPVYKK 183
>NP_001119712
          Length = 587

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 126 IRAMPVYKK 134
>NP_001119714
          Length = 426

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 126 IRAMPVYKK 134
>NP_005418
          Length = 636

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 175 IRAMPVYKK 183
>NP_001191116
          Length = 555

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 175 IRAMPVYKK 183
>NP_001191115
          Length = 403

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 175 IRAMPVYKK 183
>NP_001191119
          Length = 506

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 126 IRAMPVYKK 134
>NP_001191113
          Length = 499

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 175 IRAMPVYKK 183
>NP_001191118
          Length = 354

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 126 IRAMPVYKK 134
>NP_001191120
          Length = 491

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 126 IRAMPVYKK 134
>NP_001191114
          Length = 475

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 175 IRAMPVYKK 183
>NP_612350
          Length = 245

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RA T+YK+
Sbjct: 108 IRAQTLYKK 116
>NP_001180382
          Length = 302

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RA T+YK+
Sbjct: 165 IRAQTLYKK 173
>NP_001180460
          Length = 337

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RA T+YK+
Sbjct: 200 IRAQTLYKK 208
>XP_006719743
          Length = 245

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RA T+YK+
Sbjct: 108 IRAQTLYKK 116
>XP_006719742
          Length = 336

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RA T+YK+
Sbjct: 199 IRAQTLYKK 207
>XP_006719741
          Length = 364

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RA T+YK+
Sbjct: 227 IRAQTLYKK 235
>XP_005254043
          Length = 371

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RA T+YK+
Sbjct: 234 IRAQTLYKK 242
>XP_005254042
          Length = 394

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RA T+YK+
Sbjct: 257 IRAQTLYKK 265
>XP_005247903
          Length = 483

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 225 IRAMPVYKK 233
>XP_005247901
          Length = 663

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 208 IRAMPVYKK 216
>XP_005247900
          Length = 676

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRAMTIYKQ 9
           +RAM +YK+
Sbjct: 225 IRAMPVYKK 233
>NP_055448
          Length = 1173

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RAMTIYKQ 9
           RA+ IYKQ
Sbjct: 631 RALAIYKQ 638
>NP_001008844
          Length = 2272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VRAMTIYK 8
           +RAMTI K
Sbjct: 560 IRAMTIAK 567
>NP_004406
          Length = 2871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VRAMTIYK 8
           +RAMTI K
Sbjct: 560 IRAMTIAK 567
>NP_061923
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AMTIYKQ 9
           AMT+Y+Q
Sbjct: 156 AMTLYEQ 162
>XP_005263135
          Length = 488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AMTIYKQ 9
           AMT+Y+Q
Sbjct: 156 AMTLYEQ 162
>XP_005263134
          Length = 800

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AMTIYKQ 9
           AMT+Y+Q
Sbjct: 156 AMTLYEQ 162
>XP_006714303
          Length = 957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AMTIYKQ 9
          AMT+Y+Q
Sbjct: 40 AMTLYEQ 46
>XP_005263133
          Length = 1022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AMTIYKQ 9
           AMT+Y+Q
Sbjct: 156 AMTLYEQ 162
>XP_005263132
          Length = 1023

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AMTIYKQ 9
           AMT+Y+Q
Sbjct: 156 AMTLYEQ 162
>XP_005263131
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AMTIYKQ 9
           AMT+Y+Q
Sbjct: 156 AMTLYEQ 162
>XP_005263130
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AMTIYKQ 9
           AMT+Y+Q
Sbjct: 156 AMTLYEQ 162
>NP_061982
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VRAMTIY 7
           +RA+T+Y
Sbjct: 209 IRAVTVY 215
>NP_001013758
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    RAMTIYK 8
            RAM +YK
Sbjct: 1017 RAMQVYK 1023
>XP_005255488
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VRAMTIY 7
           +RA+T+Y
Sbjct: 209 IRAVTVY 215
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.132    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 325,000
Number of extensions: 322
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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