Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              20     390
NP_001035957                                                           20     390
XP_006721990                                                           20     390
XP_006721989                                                           20     390
XP_005258041                                                           20     390
XP_006721988                                                           20     390
XP_006721987                                                           20     390
XP_006721986                                                           20     390
XP_005258040                                                           20     390
XP_006721985                                                           20     390
XP_005255877                                                           18    1935
XP_005255876                                                           18    1935
XP_005255874                                                           18    1935
XP_006721218                                                           18    1935
XP_005255872                                                           18    1935
NP_710155                                                              18    1935
NP_003406                                                              17    4312
NP_001159354                                                           17    4312
NP_001159353                                                           17    4312
NP_008893                                                              17    4312
NP_001171570                                                           17    4312
NP_001007089                                                           17    4312
NP_001274278                                                           16    5631
NP_001275521                                                           16    5631
NP_061121                                                              16    5631
NP_001275519                                                           16    5631
XP_005265380                                                           16    5631
NP_006729                                                              16    7355
NP_001257475                                                           16    7355
NP_009131                                                              16    7355
NP_775929                                                              16    7355
XP_005254913                                                           16    7355
XP_005254912                                                           16    7355
XP_005254911                                                           16    7355
XP_005254910                                                           16    7355
XP_005254909                                                           16    7355
XP_005254908                                                           16    7355
XP_005254907                                                           16    7355
XP_005254906                                                           16    7355
XP_005254905                                                           16    7355
XP_005254904                                                           16    7355
XP_005254903                                                           16    7355
XP_005254902                                                           16    7355
XP_005254901                                                           16    7355
XP_005254900                                                           16    7355
XP_005254899                                                           16    7355
XP_005254898                                                           16    7355
XP_005254897                                                           16    7355
XP_006720441                                                           16    7355
XP_006720440                                                           16    7355
XP_006720439                                                           16    7355
XP_005254896                                                           16    7355
XP_005265147                                                           16    7355
XP_006713180                                                           16    7355
NP_001071092                                                           15    9605
XP_003960549                                                           15    9605
XP_005259833                                                           15    9605
XP_005259832                                                           15    9605
XP_005259830                                                           15    9605
XP_005259829                                                           15    9605
NP_001005276                                                           15    9605
>NP_000258
          Length = 2818

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VQSIIHMRT 9
            VQSIIH+RT
Sbjct: 1800 VQSIIHIRT 1808
>NP_001035957
          Length = 2839

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VQSIIHMRT 9
            VQSIIH+RT
Sbjct: 1821 VQSIIHIRT 1829
>XP_006721990
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VQSIIHMRT 9
            VQSIIH+RT
Sbjct: 1831 VQSIIHIRT 1839
>XP_006721989
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VQSIIHMRT 9
            VQSIIH+RT
Sbjct: 1831 VQSIIHIRT 1839
>XP_005258041
          Length = 2836

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VQSIIHMRT 9
            VQSIIH+RT
Sbjct: 1800 VQSIIHIRT 1808
>XP_006721988
          Length = 2846

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VQSIIHMRT 9
            VQSIIH+RT
Sbjct: 1810 VQSIIHIRT 1818
>XP_006721987
          Length = 2849

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VQSIIHMRT 9
            VQSIIH+RT
Sbjct: 1831 VQSIIHIRT 1839
>XP_006721986
          Length = 2854

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VQSIIHMRT 9
            VQSIIH+RT
Sbjct: 1818 VQSIIHIRT 1826
>XP_005258040
          Length = 2857

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VQSIIHMRT 9
            VQSIIH+RT
Sbjct: 1821 VQSIIHIRT 1829
>XP_006721985
          Length = 2867

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VQSIIHMRT 9
            VQSIIH+RT
Sbjct: 1831 VQSIIHIRT 1839
>XP_005255877
          Length = 352

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q IIHMRT
Sbjct: 283 QLIIHMRT 290
>XP_005255876
          Length = 352

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q IIHMRT
Sbjct: 283 QLIIHMRT 290
>XP_005255874
          Length = 407

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q IIHMRT
Sbjct: 338 QLIIHMRT 345
>XP_006721218
          Length = 407

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q IIHMRT
Sbjct: 338 QLIIHMRT 345
>XP_005255872
          Length = 430

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q IIHMRT
Sbjct: 361 QLIIHMRT 368
>NP_710155
          Length = 407

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q IIHMRT
Sbjct: 338 QLIIHMRT 345
>NP_003406
          Length = 947

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IIHMRT 9
           IIHMRT
Sbjct: 712 IIHMRT 717

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IIHMRT 9
           IIHMRT
Sbjct: 796 IIHMRT 801
>NP_001159354
          Length = 864

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IIHMRT 9
           IIHMRT
Sbjct: 629 IIHMRT 634

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IIHMRT 9
           IIHMRT
Sbjct: 713 IIHMRT 718
>NP_001159353
          Length = 947

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IIHMRT 9
           IIHMRT
Sbjct: 712 IIHMRT 717

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IIHMRT 9
           IIHMRT
Sbjct: 796 IIHMRT 801
>NP_008893
          Length = 639

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q IIH+RT
Sbjct: 276 QLIIHLRT 283
>NP_001171570
          Length = 639

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q IIH+RT
Sbjct: 276 QLIIHLRT 283
>NP_001007089
          Length = 620

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q IIH+RT
Sbjct: 257 QLIIHLRT 264
>NP_001274278
          Length = 530

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q I+H+RT
Sbjct: 201 QLIVHLRT 208
>NP_001275521
          Length = 373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q I+H+RT
Sbjct: 274 QLIVHLRT 281
>NP_061121
          Length = 754

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q I+H+RT
Sbjct: 425 QLIVHLRT 432
>NP_001275519
          Length = 754

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q I+H+RT
Sbjct: 425 QLIVHLRT 432
>XP_005265380
          Length = 753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q I+H+RT
Sbjct: 424 QLIVHLRT 431
>NP_006729
          Length = 2817

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2526 VQSVVHL 2532
>NP_001257475
          Length = 1434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 1143 VQSVVHL 1149
>NP_009131
          Length = 2813

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2522 VQSVVHL 2528
>NP_775929
          Length = 331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q I+H+RT
Sbjct: 288 QVILHLRT 295
>XP_005254913
          Length = 1441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 1150 VQSVVHL 1156
>XP_005254912
          Length = 1442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 1151 VQSVVHL 1157
>XP_005254911
          Length = 1473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 1182 VQSVVHL 1188
>XP_005254910
          Length = 1523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 1232 VQSVVHL 1238
>XP_005254909
          Length = 1536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 1245 VQSVVHL 1251
>XP_005254908
          Length = 1536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 1245 VQSVVHL 1251
>XP_005254907
          Length = 2590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2299 VQSVVHL 2305
>XP_005254906
          Length = 2675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2384 VQSVVHL 2390
>XP_005254905
          Length = 2793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2502 VQSVVHL 2508
>XP_005254904
          Length = 2802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2511 VQSVVHL 2517
>XP_005254903
          Length = 2820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2529 VQSVVHL 2535
>XP_005254902
          Length = 2835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2544 VQSVVHL 2550
>XP_005254901
          Length = 2842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2551 VQSVVHL 2557
>XP_005254900
          Length = 2843

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2552 VQSVVHL 2558
>XP_005254899
          Length = 2861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2570 VQSVVHL 2576
>XP_005254898
          Length = 2874

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2583 VQSVVHL 2589
>XP_005254897
          Length = 2876

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2585 VQSVVHL 2591
>XP_006720441
          Length = 2881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2590 VQSVVHL 2596
>XP_006720440
          Length = 2882

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2591 VQSVVHL 2597
>XP_006720439
          Length = 2882

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2591 VQSVVHL 2597
>XP_005254896
          Length = 2883

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    VQSIIHM 7
            VQS++H+
Sbjct: 2592 VQSVVHL 2598
>XP_005265147
          Length = 331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q I+H+RT
Sbjct: 288 QVILHLRT 295
>XP_006713180
          Length = 331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QSIIHMRT 9
           Q I+H+RT
Sbjct: 288 QVILHLRT 295
>NP_001071092
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   IIHMRT 9
           ++HMRT
Sbjct: 382 VLHMRT 387
>XP_003960549
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VQSIIHM 7
           VQS++H+
Sbjct: 238 VQSVLHL 244
>XP_005259833
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   IIHMRT 9
           ++HMRT
Sbjct: 253 VLHMRT 258
>XP_005259832
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   IIHMRT 9
           ++HMRT
Sbjct: 381 VLHMRT 386
>XP_005259830
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   IIHMRT 9
           ++HMRT
Sbjct: 381 VLHMRT 386
>XP_005259829
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   IIHMRT 9
           ++HMRT
Sbjct: 382 VLHMRT 387
>NP_001005276
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VQSIIHMRT 9
           +QS+I MR+
Sbjct: 221 LQSVIQMRS 229
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.134    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 439,924
Number of extensions: 539
Number of successful extensions: 64
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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