Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000242                                                              18    1135
XP_005264389                                                           18    1135
NP_002514                                                              17    2528
NP_598400                                                              17    4312
XP_006715512                                                           17    4312
XP_006715511                                                           17    4312
XP_006715508                                                           17    4312
XP_006715507                                                           17    4312
NP_001116698                                                           17    4312
NP_036255                                                              17    4312
NP_004703                                                              16    5631
NP_001077086                                                           16    5631
NP_055596                                                              16    5631
XP_005257851                                                           16    5631
XP_006716556                                                           16    5631
XP_006716555                                                           16    5631
XP_006716554                                                           16    5631
NP_001002264                                                           16    7355
NP_150280                                                              16    7355
NP_079504                                                              16    7355
NP_060139                                                              16    7355
NP_004220                                                              16    7355
NP_001008392                                                           16    7355
XP_005272758                                                           16    7355
XP_005272757                                                           16    7355
XP_005272756                                                           16    7355
XP_006719959                                                           16    7355
XP_005266654                                                           16    7355
XP_005266653                                                           16    7355
XP_005273337                                                           16    7355
XP_005273336                                                           16    7355
NP_002461                                                              15    9605
NP_001154976                                                           15    9605
NP_733844                                                              15    9605
NP_003739                                                              15    9605
XP_006721591                                                           15    9605
XP_006719509                                                           15    9605
XP_006710587                                                           15    9605
NP_002513                                                              15    9605
>NP_000242
          Length = 934

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VQQKETLQL 9
          VQ KETLQL
Sbjct: 3  VQPKETLQL 11
>XP_005264389
          Length = 921

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VQQKETLQL 9
          VQ KETLQL
Sbjct: 3  VQPKETLQL 11
>NP_002514
          Length = 431

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1  VQQKETL 7
          VQQKETL
Sbjct: 71 VQQKETL 77
>NP_598400
          Length = 717

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VQQKETLQL 9
           VQQ E LQL
Sbjct: 627 VQQDEALQL 635
>XP_006715512
          Length = 354

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VQQKETLQL 9
           VQQ E LQL
Sbjct: 264 VQQDEALQL 272
>XP_006715511
          Length = 354

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VQQKETLQL 9
           VQQ E LQL
Sbjct: 264 VQQDEALQL 272
>XP_006715508
          Length = 618

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VQQKETLQL 9
           VQQ E LQL
Sbjct: 528 VQQDEALQL 536
>XP_006715507
          Length = 618

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VQQKETLQL 9
           VQQ E LQL
Sbjct: 528 VQQDEALQL 536
>NP_001116698
          Length = 732

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VQQKETLQL 9
           VQQ E LQL
Sbjct: 642 VQQDEALQL 650
>NP_036255
          Length = 692

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VQQKETLQL 9
           VQQ E LQL
Sbjct: 602 VQQDEALQL 610
>NP_004703
          Length = 777

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QQKETLQL 9
           QQK+T+Q+
Sbjct: 549 QQKQTVQM 556
>NP_001077086
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    QQKETLQ 8
            QQKETL+
Sbjct: 1084 QQKETLK 1090
>NP_055596
          Length = 1594

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    QQKETLQ 8
            QQKETL+
Sbjct: 1084 QQKETLK 1090
>XP_005257851
          Length = 768

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QQKETLQL 9
           QQK+T+Q+
Sbjct: 540 QQKQTVQM 547
>XP_006716556
          Length = 1048

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QQKETLQ 8
           QQKETL+
Sbjct: 541 QQKETLK 547
>XP_006716555
          Length = 1539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    QQKETLQ 8
            QQKETL+
Sbjct: 1032 QQKETLK 1038
>XP_006716554
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    QQKETLQ 8
            QQKETL+
Sbjct: 1084 QQKETLK 1090
>NP_001002264
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQQKETLQL 9
           V+QK+ LQL
Sbjct: 119 VRQKQQLQL 127
>NP_150280
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQQKETLQL 9
           V+QK+ LQL
Sbjct: 119 VRQKQQLQL 127
>NP_079504
          Length = 551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QKETLQL 9
           QK+TLQL
Sbjct: 471 QKKTLQL 477
>NP_060139
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   QKETLQ 8
           QKETLQ
Sbjct: 844 QKETLQ 849
>NP_004220
          Length = 1454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    QKETLQL 9
            Q+ETLQL
Sbjct: 1225 QQETLQL 1231
>NP_001008392
          Length = 1079

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  QKETLQ 8
          QKETLQ
Sbjct: 68 QKETLQ 73
>XP_005272758
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    QKETLQL 9
            Q+ETLQL
Sbjct: 1109 QQETLQL 1115
>XP_005272757
          Length = 1410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    QKETLQL 9
            Q+ETLQL
Sbjct: 1181 QQETLQL 1187
>XP_005272756
          Length = 1443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    QKETLQL 9
            Q+ETLQL
Sbjct: 1225 QQETLQL 1231
>XP_006719959
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQQKETLQL 9
           V+QK+ LQL
Sbjct: 119 VRQKQQLQL 127
>XP_005266654
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQQKETLQL 9
           V+QK+ LQL
Sbjct: 119 VRQKQQLQL 127
>XP_005266653
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQQKETLQL 9
           V+QK+ LQL
Sbjct: 119 VRQKQQLQL 127
>XP_005273337
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QKETLQL 9
           QK+TLQL
Sbjct: 207 QKKTLQL 213
>XP_005273336
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QKETLQL 9
           QK+TLQL
Sbjct: 207 QKKTLQL 213
>NP_002461
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VQQKETLQL 9
           VQ+K  LQL
Sbjct: 882 VQEKNDLQL 890
>NP_001154976
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KETLQL 9
           KETLQL
Sbjct: 404 KETLQL 409
>NP_733844
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KETLQL 9
           KETLQL
Sbjct: 464 KETLQL 469
>NP_003739
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KETLQL 9
           KETLQL
Sbjct: 464 KETLQL 469
>XP_006721591
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VQQKETLQL 9
           VQ+K  LQL
Sbjct: 882 VQEKNDLQL 890
>XP_006719509
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VQQKETLQL 9
           ++QKETL +
Sbjct: 851 LEQKETLNV 859
>XP_006710587
          Length = 7645

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VQQKETLQ 8
            +QQ ETLQ
Sbjct: 3688 LQQYETLQ 3695
>NP_002513
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VQQKETL 7
          +QQKET+
Sbjct: 66 LQQKETI 72
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.121    0.274 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 544,625
Number of extensions: 1150
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package