Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1135
XP_005262424                                                           18    1135
NP_000205                                                              17    4312
NP_005095                                                              17    4312
NP_001186384                                                           17    4312
NP_001106653                                                           17    4312
NP_001136438                                                           17    4312
NP_001186385                                                           17    4312
XP_006722611                                                           17    4312
XP_006722610                                                           17    4312
NP_001277189                                                           16    5631
NP_055968                                                              16    5631
NP_001277188                                                           16    5631
XP_005248759                                                           16    5631
XP_006715489                                                           16    5631
XP_005248758                                                           16    5631
NP_005662                                                              16    7355
NP_001269128                                                           16    7355
NP_955450                                                              16    7355
NP_004632                                                              15    9605
NP_001182555                                                           15    9605
NP_001271317                                                           15    9605
NP_004732                                                              15    9605
NP_001271318                                                           15    9605
NP_477520                                                              15    9605
NP_001139266                                                           15    9605
NP_001273710                                                           15    9605
NP_001273709                                                           15    9605
NP_055309                                                              15    9605
NP_001140166                                                           15    9605
XP_006722792                                                           15    9605
XP_006721103                                                           15    9605
XP_005255314                                                           15    9605
XP_006721102                                                           15    9605
XP_005255313                                                           15    9605
XP_005255312                                                           15    9605
XP_006721101                                                           15    9605
XP_005255311                                                           15    9605
XP_005255310                                                           15    9605
XP_005270330                                                           15    9605
XP_005252668                                                           15    9605
XP_006717572                                                           15    9605
XP_005252667                                                           15    9605
XP_005252666                                                           15    9605
XP_005252665                                                           15    9605
XP_005252663                                                           15    9605
XP_005252662                                                           15    9605
NP_001129973                                                           15    9605
>NP_722576
          Length = 3080

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VQLNSVKS 8
            VQLNSVKS
Sbjct: 2918 VQLNSVKS 2925
>XP_005262424
          Length = 2875

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VQLNSVKS 8
            VQLNSVKS
Sbjct: 2713 VQLNSVKS 2720
>NP_000205
          Length = 1218

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    QLNSVKSP 9
            QLN +K+P
Sbjct: 1118 QLNQIKNP 1125
>NP_005095
          Length = 801

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QLNSVKSP 9
           QLNS K P
Sbjct: 746 QLNSTKKP 753
>NP_001186384
          Length = 836

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QLNSVKSP 9
           QLNS K P
Sbjct: 781 QLNSTKKP 788
>NP_001106653
          Length = 801

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QLNSVKSP 9
           QLNS K P
Sbjct: 746 QLNSTKKP 753
>NP_001136438
          Length = 1923

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LNSVKSP 9
            LN+VKSP
Sbjct: 1512 LNAVKSP 1518
>NP_001186385
          Length = 754

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QLNSVKSP 9
           QLNS K P
Sbjct: 699 QLNSTKKP 706
>XP_006722611
          Length = 1034

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LNSVKSP 9
           LN+VKSP
Sbjct: 623 LNAVKSP 629
>XP_006722610
          Length = 1967

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LNSVKSP 9
            LN+VKSP
Sbjct: 1556 LNAVKSP 1562
>NP_001277189
          Length = 736

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNSVKSP 9
           V+ NSV+SP
Sbjct: 118 VEENSVRSP 126
>NP_055968
          Length = 2039

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNSVKSP 9
           V+ NSV+SP
Sbjct: 118 VEENSVRSP 126
>NP_001277188
          Length = 1951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VQLNSVKSP 9
          V+ NSV+SP
Sbjct: 30 VEENSVRSP 38
>XP_005248759
          Length = 1951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VQLNSVKSP 9
          V+ NSV+SP
Sbjct: 30 VEENSVRSP 38
>XP_006715489
          Length = 2039

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNSVKSP 9
           V+ NSV+SP
Sbjct: 118 VEENSVRSP 126
>XP_005248758
          Length = 2039

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNSVKSP 9
           V+ NSV+SP
Sbjct: 118 VEENSVRSP 126
>NP_005662
          Length = 270

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  LNSVKSP 9
          LNS KSP
Sbjct: 59 LNSFKSP 65
>NP_001269128
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  LNSVKSP 9
          LNS KSP
Sbjct: 59 LNSFKSP 65
>NP_955450
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VQLNSVKSP 9
          +QLN  K+P
Sbjct: 68 IQLNHYKTP 76
>NP_004632
          Length = 1027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSVKSP 9
           LNS KSP
Sbjct: 825 LNSSKSP 831
>NP_001182555
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSVKSP 9
           LNS KSP
Sbjct: 809 LNSSKSP 815
>NP_001271317
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VQLNSVK 7
           VQ+NS+K
Sbjct: 699 VQVNSIK 705
>NP_004732
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VQLNSVK 7
           VQ+NS+K
Sbjct: 689 VQVNSIK 695
>NP_001271318
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VQLNSVK 7
           VQ+NS+K
Sbjct: 690 VQVNSIK 696
>NP_477520
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VQLNSVKSP 9
           VQLNS+  P
Sbjct: 272 VQLNSMLCP 280
>NP_001139266
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VQLNSVKSP 9
           VQLNS+  P
Sbjct: 272 VQLNSMLCP 280
>NP_001273710
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VQLNSVKSP 9
           VQLNS+  P
Sbjct: 195 VQLNSMLCP 203
>NP_001273709
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VQLNSVKSP 9
           VQLNS+  P
Sbjct: 195 VQLNSMLCP 203
>NP_055309
          Length = 1962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VQLNSVKSP 9
            + +NS+K P
Sbjct: 1523 MDMNSIKEP 1531
>NP_001140166
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    QLNSVKSP 9
            Q+NS+ SP
Sbjct: 1010 QVNSLSSP 1017
>XP_006722792
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VQLNSVKSP 9
           + LN+VK P
Sbjct: 375 MNLNNVKKP 383
>XP_006721103
          Length = 1597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VQLNSVKSP 9
            + +NS+K P
Sbjct: 1491 MDMNSIKEP 1499
>XP_005255314
          Length = 1709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VQLNSVKSP 9
            + +NS+K P
Sbjct: 1270 MDMNSIKEP 1278
>XP_006721102
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VQLNSVKSP 9
            + +NS+K P
Sbjct: 1381 MDMNSIKEP 1389
>XP_005255313
          Length = 1822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VQLNSVKSP 9
            + +NS+K P
Sbjct: 1383 MDMNSIKEP 1391
>XP_005255312
          Length = 1871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VQLNSVKSP 9
            + +NS+K P
Sbjct: 1432 MDMNSIKEP 1440
>XP_006721101
          Length = 1907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VQLNSVKSP 9
            + +NS+K P
Sbjct: 1468 MDMNSIKEP 1476
>XP_005255311
          Length = 1913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VQLNSVKSP 9
            + +NS+K P
Sbjct: 1474 MDMNSIKEP 1482
>XP_005255310
          Length = 1919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VQLNSVKSP 9
            + +NS+K P
Sbjct: 1480 MDMNSIKEP 1488
>XP_005270330
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VQLNSVK 7
           VQ+NS+K
Sbjct: 700 VQVNSIK 706
>XP_005252668
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSVKSP 9
           LNS KSP
Sbjct: 580 LNSSKSP 586
>XP_006717572
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSVKSP 9
           LNS KSP
Sbjct: 825 LNSSKSP 831
>XP_005252667
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSVKSP 9
           LNS KSP
Sbjct: 793 LNSSKSP 799
>XP_005252666
          Length = 1057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSVKSP 9
           LNS KSP
Sbjct: 798 LNSSKSP 804
>XP_005252665
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSVKSP 9
           LNS KSP
Sbjct: 809 LNSSKSP 815
>XP_005252663
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSVKSP 9
           LNS KSP
Sbjct: 825 LNSSKSP 831
>XP_005252662
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNSVKSP 9
           LNS KSP
Sbjct: 825 LNSSKSP 831
>NP_001129973
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VQLNSVKSP 9
           + LN+VK P
Sbjct: 532 MNLNNVKKP 540
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.116    0.292 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 413,032
Number of extensions: 634
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package