Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              21     175
NP_057434                                                              17    2528
NP_891989                                                              17    2528
NP_065972                                                              17    2528
NP_891991                                                              17    2528
XP_006720224                                                           17    2528
XP_005267794                                                           17    2528
XP_005267793                                                           17    2528
XP_005267792                                                           17    2528
XP_006720223                                                           17    2528
NP_001258857                                                           17    3301
NP_001258856                                                           17    3301
NP_060046                                                              17    3301
XP_005252148                                                           17    3301
XP_006717241                                                           17    3301
XP_006717240                                                           17    3301
XP_005252147                                                           17    3301
XP_005252146                                                           17    3301
XP_006717239                                                           17    3301
NP_000768                                                              17    4312
XP_006715923                                                           17    4312
XP_006715922                                                           17    4312
NP_073619                                                              16    5631
XP_006719254                                                           16    5631
XP_006719253                                                           16    5631
XP_006719252                                                           16    5631
XP_006719251                                                           16    5631
XP_006719250                                                           16    5631
NP_004612                                                              16    7355
NP_056340                                                              16    7355
NP_001122312                                                           16    7355
NP_001122311                                                           16    7355
NP_000711                                                              16    7355
NP_055620                                                              16    7355
XP_006718961                                                           16    7355
XP_005249968                                                           16    7355
XP_005249966                                                           16    7355
XP_006715864                                                           16    7355
XP_005249965                                                           16    7355
XP_006715518                                                           16    7355
XP_006715517                                                           16    7355
XP_006715516                                                           16    7355
XP_005265505                                                           16    7355
XP_006713388                                                           16    7355
NP_861524                                                              16    7355
NP_001155967                                                           15    9605
NP_001155968                                                           15    9605
NP_062542                                                              15    9605
NP_001271230                                                           15    9605
NP_001273675                                                           15    9605
NP_001271231                                                           15    9605
NP_061155                                                              15    9605
NP_001273676                                                           15    9605
NP_078997                                                              15    9605
NP_525023                                                              15    9605
NP_115689                                                              15    9605
NP_008816                                                              15    9605
NP_003963                                                              15    9605
NP_079084                                                              15    9605
XP_006721855                                                           15    9605
XP_006721854                                                           15    9605
XP_006721853                                                           15    9605
XP_005256014                                                           15    9605
XP_006719931                                                           15    9605
XP_005270323                                                           15    9605
XP_005270322                                                           15    9605
XP_006715810                                                           15    9605
XP_006715809                                                           15    9605
>NP_004251
          Length = 1208

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VQLNMKQKH 9
           V+LNMKQKH
Sbjct: 354 VRLNMKQKH 362
>NP_057434
          Length = 1377

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           Q NMKQ+H
Sbjct: 651 QENMKQRH 658
>NP_891989
          Length = 2046

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           Q NMKQ+H
Sbjct: 651 QENMKQRH 658
>NP_065972
          Length = 2133

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           Q NMKQ+H
Sbjct: 651 QENMKQRH 658
>NP_891991
          Length = 2090

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           Q NMKQ+H
Sbjct: 651 QENMKQRH 658
>XP_006720224
          Length = 1276

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           Q NMKQ+H
Sbjct: 651 QENMKQRH 658
>XP_005267794
          Length = 1379

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           Q NMKQ+H
Sbjct: 651 QENMKQRH 658
>XP_005267793
          Length = 1390

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           Q NMKQ+H
Sbjct: 621 QENMKQRH 628
>XP_005267792
          Length = 1420

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           Q NMKQ+H
Sbjct: 651 QENMKQRH 658
>XP_006720223
          Length = 1989

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           Q NMKQ+H
Sbjct: 651 QENMKQRH 658
>NP_001258857
          Length = 1304

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           V+LN KQ+H
Sbjct: 429 VRLNEKQQH 437
>NP_001258856
          Length = 1335

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           V+LN KQ+H
Sbjct: 429 VRLNEKQQH 437
>NP_060046
          Length = 1401

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           V+LN KQ+H
Sbjct: 429 VRLNEKQQH 437
>XP_005252148
          Length = 1043

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VQLNMKQKH 9
          V+LN KQ+H
Sbjct: 71 VRLNEKQQH 79
>XP_006717241
          Length = 1136

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           V+LN KQ+H
Sbjct: 429 VRLNEKQQH 437
>XP_006717240
          Length = 1235

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           V+LN KQ+H
Sbjct: 429 VRLNEKQQH 437
>XP_005252147
          Length = 1329

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           V+LN KQ+H
Sbjct: 429 VRLNEKQQH 437
>XP_005252146
          Length = 1342

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           V+LN KQ+H
Sbjct: 429 VRLNEKQQH 437
>XP_006717239
          Length = 1401

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           V+LN KQ+H
Sbjct: 429 VRLNEKQQH 437
>NP_000768
          Length = 502

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           +LN KQKH
Sbjct: 260 RLNDKQKH 267
>XP_006715923
          Length = 322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QLNMKQKH 9
          +LN KQKH
Sbjct: 80 RLNDKQKH 87
>XP_006715922
          Length = 381

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           +LN KQKH
Sbjct: 260 RLNDKQKH 267
>NP_073619
          Length = 1183

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           ++ N+K+KH
Sbjct: 595 IRQNLKEKH 603
>XP_006719254
          Length = 810

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           ++ N+K+KH
Sbjct: 222 IRQNLKEKH 230
>XP_006719253
          Length = 1031

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           ++ N+K+KH
Sbjct: 443 IRQNLKEKH 451
>XP_006719252
          Length = 1031

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           ++ N+K+KH
Sbjct: 443 IRQNLKEKH 451
>XP_006719251
          Length = 1116

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           ++ N+K+KH
Sbjct: 528 IRQNLKEKH 536
>XP_006719250
          Length = 1141

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           ++ N+K+KH
Sbjct: 553 IRQNLKEKH 561
>NP_004612
          Length = 931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   NMKQKH 9
           N KQKH
Sbjct: 259 NQKQKH 264
>NP_056340
          Length = 1353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           ++NM+Q H
Sbjct: 963 EINMEQNH 970
>NP_001122312
          Length = 2161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLNMKQK 8
           +LNMK+K
Sbjct: 850 ELNMKEK 856
>NP_001122311
          Length = 2137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLNMKQK 8
           +LNMK+K
Sbjct: 850 ELNMKEK 856
>NP_000711
          Length = 2181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLNMKQK 8
           +LNMK+K
Sbjct: 870 ELNMKEK 876
>NP_055620
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           V+LN+ Q+H
Sbjct: 417 VKLNLFQRH 425
>XP_006718961
          Length = 906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   NMKQKH 9
           N KQKH
Sbjct: 259 NQKQKH 264
>XP_005249968
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QLNMKQKH 9
           +LNM+QK+
Sbjct: 663 ELNMEQKN 670
>XP_005249966
          Length = 948

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QLNMKQKH 9
           +LNM+QK+
Sbjct: 938 ELNMEQKN 945
>XP_006715864
          Length = 957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QLNMKQKH 9
           +LNM+QK+
Sbjct: 947 ELNMEQKN 954
>XP_005249965
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QLNMKQKH 9
           +LNM+QK+
Sbjct: 948 ELNMEQKN 955
>XP_006715518
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           ++NM+Q H
Sbjct: 963 EINMEQNH 970
>XP_006715517
          Length = 1379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           ++NM+Q H
Sbjct: 963 EINMEQNH 970
>XP_006715516
          Length = 1394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           ++NM+Q H
Sbjct: 963 EINMEQNH 970
>XP_005265505
          Length = 2146

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLNMKQK 8
           +LNMK+K
Sbjct: 850 ELNMKEK 856
>XP_006713388
          Length = 2194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLNMKQK 8
           +LNMK+K
Sbjct: 870 ELNMKEK 876
>NP_861524
          Length = 900

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LNMKQKH 9
           +N+K+KH
Sbjct: 152 INLKRKH 158
>NP_001155967
          Length = 219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           +++NM+ KH
Sbjct: 125 LRINMEAKH 133
>NP_001155968
          Length = 219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           +++NM+ KH
Sbjct: 125 LRINMEAKH 133
>NP_062542
          Length = 219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           +++NM+ KH
Sbjct: 125 LRINMEAKH 133
>NP_001271230
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLNMKQK 8
           Q+N+KQK
Sbjct: 676 QVNIKQK 682
>NP_001273675
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   NMKQKH 9
           NMKQ H
Sbjct: 611 NMKQDH 616
>NP_001271231
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLNMKQK 8
           Q+N+KQK
Sbjct: 675 QVNIKQK 681
>NP_061155
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLNMKQK 8
           Q+N+KQK
Sbjct: 713 QVNIKQK 719
>NP_001273676
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   NMKQKH 9
           NMKQ H
Sbjct: 466 NMKQDH 471
>NP_078997
          Length = 3616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           ++ +MK+KH
Sbjct: 659 LEAHMKEKH 667
>NP_525023
          Length = 1617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3 LNMKQK 8
         +NMKQK
Sbjct: 1 MNMKQK 6
>NP_115689
          Length = 698

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QLNMKQKH 9
           QLN+ +KH
Sbjct: 425 QLNVLKKH 432
>NP_008816
          Length = 3703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           ++ +MK+KH
Sbjct: 686 LEAHMKEKH 694
>NP_003963
          Length = 1849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VQLNMKQKH 9
            +QL  K++H
Sbjct: 1234 IQLKAKERH 1242
>NP_079084
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   NMKQKH 9
           NMKQ H
Sbjct: 596 NMKQDH 601
>XP_006721855
          Length = 1551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3 LNMKQK 8
         +NMKQK
Sbjct: 1 MNMKQK 6
>XP_006721854
          Length = 1577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3 LNMKQK 8
         +NMKQK
Sbjct: 1 MNMKQK 6
>XP_006721853
          Length = 1617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3 LNMKQK 8
         +NMKQK
Sbjct: 1 MNMKQK 6
>XP_005256014
          Length = 3702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VQLNMKQKH 9
           ++ +MK+KH
Sbjct: 686 LEAHMKEKH 694
>XP_006719931
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   NMKQKH 9
           NMKQ H
Sbjct: 485 NMKQDH 490
>XP_005270323
          Length = 1519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VQLNMKQKH 9
           +QL  K++H
Sbjct: 904 IQLKAKERH 912
>XP_005270322
          Length = 1646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VQLNMKQKH 9
            +QL  K++H
Sbjct: 1031 IQLKAKERH 1039
>XP_006715810
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLNMKQK 8
           Q+N+KQK
Sbjct: 676 QVNIKQK 682
>XP_006715809
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   QLNMKQK 8
           Q+N+KQK
Sbjct: 713 QVNIKQK 719
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.122    0.331 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 496,852
Number of extensions: 1009
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package