Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              18    1482
XP_006714104                                                           18    1482
XP_005265800                                                           18    1482
XP_006714103                                                           18    1482
XP_006714102                                                           18    1482
NP_000531                                                              17    2528
NP_001036188                                                           17    2528
XP_006723382                                                           17    2528
XP_006723381                                                           17    2528
XP_006723380                                                           17    2528
NP_060485                                                              17    3301
NP_001171711                                                           17    3301
NP_849157                                                              17    4312
NP_722576                                                              17    4312
XP_005262424                                                           17    4312
XP_006714159                                                           17    4312
XP_006714158                                                           17    4312
XP_006714157                                                           17    4312
NP_071414                                                              17    4312
NP_001177344                                                           16    5631
NP_647476                                                              16    5631
NP_005632                                                              16    5631
XP_005276286                                                           16    5631
XP_005277590                                                           16    5631
XP_006716165                                                           16    5631
XP_006716164                                                           16    5631
XP_006716163                                                           16    5631
XP_005265698                                                           16    5631
XP_005276004                                                           16    5631
NP_056280                                                              16    7355
NP_001239085                                                           16    7355
NP_006423                                                              15    9605
NP_733779                                                              15    9605
NP_037524                                                              15    9605
NP_008861                                                              15    9605
NP_112153                                                              15    9605
XP_006720067                                                           15    9605
XP_005264331                                                           15    9605
>NP_006197
          Length = 1089

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           VPSIKLV T
Sbjct: 266 VPSIKLVYT 274
>XP_006714104
          Length = 832

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           VPSIKLV T
Sbjct: 291 VPSIKLVYT 299
>XP_005265800
          Length = 1089

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           VPSIKLV T
Sbjct: 266 VPSIKLVYT 274
>XP_006714103
          Length = 1111

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           VPSIKLV T
Sbjct: 288 VPSIKLVYT 296
>XP_006714102
          Length = 1114

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           VPSIKLV T
Sbjct: 291 VPSIKLVYT 299
>NP_000531
          Length = 5038

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VPSIKLVST 9
            VP +KLVST
Sbjct: 1839 VPVLKLVST 1847
>NP_001036188
          Length = 5033

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VPSIKLVST 9
            VP +KLVST
Sbjct: 1839 VPVLKLVST 1847
>XP_006723382
          Length = 5027

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VPSIKLVST 9
            VP +KLVST
Sbjct: 1839 VPVLKLVST 1847
>XP_006723381
          Length = 5031

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VPSIKLVST 9
            VP +KLVST
Sbjct: 1838 VPVLKLVST 1846
>XP_006723380
          Length = 5032

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    VPSIKLVST 9
            VP +KLVST
Sbjct: 1839 VPVLKLVST 1847
>NP_060485
          Length = 855

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PSIKLVST 9
           P IKL+ST
Sbjct: 318 PQIKLIST 325
>NP_001171711
          Length = 758

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PSIKLVST 9
           P IKL+ST
Sbjct: 318 PQIKLIST 325
>NP_849157
          Length = 1077

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           V S+KLVST
Sbjct: 866 VHSVKLVST 874
>NP_722576
          Length = 3080

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           VPS+ ++ST
Sbjct: 783 VPSVDIIST 791
>XP_005262424
          Length = 2875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           VPS+ ++ST
Sbjct: 578 VPSVDIIST 586
>XP_006714159
          Length = 1077

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           V S+KLVST
Sbjct: 866 VHSVKLVST 874
>XP_006714158
          Length = 1077

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           V S+KLVST
Sbjct: 866 VHSVKLVST 874
>XP_006714157
          Length = 1077

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           V S+KLVST
Sbjct: 866 VHSVKLVST 874
>NP_071414
          Length = 955

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PSIKLVST 9
           P IK+VST
Sbjct: 660 PDIKIVST 667
>NP_001177344
          Length = 714

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PSIKLVST 9
           P +KLVST
Sbjct: 617 PIVKLVST 624
>NP_647476
          Length = 677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PSIKLVST 9
           P +KLVST
Sbjct: 580 PIVKLVST 587
>NP_005632
          Length = 677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PSIKLVST 9
           P +KLVST
Sbjct: 580 PIVKLVST 587
>XP_005276286
          Length = 642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           +P I++VST
Sbjct: 480 IPGIQIVST 488
>XP_005277590
          Length = 900

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           +P I++VST
Sbjct: 787 IPGIQIVST 795
>XP_006716165
          Length = 667

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PSIKLVST 9
           P +KLVST
Sbjct: 570 PIVKLVST 577
>XP_006716164
          Length = 667

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PSIKLVST 9
           P +KLVST
Sbjct: 570 PIVKLVST 577
>XP_006716163
          Length = 677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PSIKLVST 9
           P +KLVST
Sbjct: 580 PIVKLVST 587
>XP_005265698
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           +P I++VST
Sbjct: 464 IPGIQIVST 472
>XP_005276004
          Length = 584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           +P I++VST
Sbjct: 471 IPGIQIVST 479
>NP_056280
          Length = 1508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           +P++KL+ T
Sbjct: 565 IPNLKLICT 573
>NP_001239085
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VPSIKLVST 9
           +P++KL+ T
Sbjct: 564 IPNLKLICT 572
>NP_006423
          Length = 151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PSIKLV 7
           PSIKLV
Sbjct: 120 PSIKLV 125
>NP_733779
          Length = 163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1 VPSIKLVST 9
         +PSIKL S+
Sbjct: 1 MPSIKLQSS 9
>NP_037524
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VPSIKLVS 8
           VPS+KL++
Sbjct: 330 VPSLKLLA 337
>NP_008861
          Length = 160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1 VPSIKLVST 9
         +PSIKL S+
Sbjct: 1 MPSIKLQSS 9
>NP_112153
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  PSIKLVST 9
          PS+ LVST
Sbjct: 9  PSLLLVST 16
>XP_006720067
          Length = 174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PSIKLV 7
           PSIKLV
Sbjct: 120 PSIKLV 125
>XP_005264331
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VPSIKLVS 8
           VPS+KL++
Sbjct: 330 VPSLKLLA 337
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.126    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 508,098
Number of extensions: 711
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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