Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           20     390
NP_036462                                                              20     390
NP_001243397                                                           20     390
XP_005269721                                                           20     390
NP_001092882                                                           18    1135
NP_006757                                                              18    1135
NP_001092883                                                           18    1135
XP_005273706                                                           18    1135
NP_001157576                                                           16    5631
NP_001157577                                                           16    5631
NP_061868                                                              16    5631
NP_001157578                                                           16    5631
XP_005261981                                                           16    5631
XP_006724481                                                           16    5631
XP_005261980                                                           16    5631
NP_000431                                                              16    7355
NP_006195                                                              16    7355
NP_064506                                                              16    7355
NP_001139686                                                           16    7355
NP_001139685                                                           16    7355
NP_073608                                                              16    7355
NP_055108                                                              16    7355
XP_006719629                                                           16    7355
XP_006719628                                                           16    7355
XP_006719627                                                           16    7355
XP_006719626                                                           16    7355
NP_000775                                                              15    9605
NP_001140                                                              15    9605
NP_001191332                                                           15    9605
NP_001191333                                                           15    9605
NP_066267                                                              15    9605
NP_001032961                                                           15    9605
NP_057400                                                              15    9605
NP_001139187                                                           15    9605
XP_006724219                                                           15    9605
XP_006724218                                                           15    9605
XP_006724217                                                           15    9605
XP_005269773                                                           15    9605
XP_006717866                                                           15    9605
XP_005269772                                                           15    9605
XP_006717865                                                           15    9605
XP_006717864                                                           15    9605
XP_006717863                                                           15    9605
XP_006717862                                                           15    9605
XP_006717861                                                           15    9605
XP_006717860                                                           15    9605
XP_006717859                                                           15    9605
XP_006717858                                                           15    9605
XP_006717857                                                           15    9605
XP_006717856                                                           15    9605
XP_006717855                                                           15    9605
XP_006717854                                                           15    9605
XP_006717853                                                           15    9605
XP_006717852                                                           15    9605
XP_006717851                                                           15    9605
XP_006717850                                                           15    9605
XP_006717849                                                           15    9605
XP_006717848                                                           15    9605
XP_006717847                                                           15    9605
XP_006717846                                                           15    9605
XP_006717845                                                           15    9605
XP_006716050                                                           15    9605
XP_006712656                                                           15    9605
XP_005264025                                                           15    9605
XP_006712655                                                           15    9605
NP_777557                                                              15    9605
NP_689726                                                              15    9605
>NP_001243398
          Length = 1781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNLM APAY
Sbjct: 1677 VNLMPAPAY 1685
>NP_036462
          Length = 2073

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNLM APAY
Sbjct: 1969 VNLMPAPAY 1977
>NP_001243397
          Length = 1890

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNLM APAY
Sbjct: 1786 VNLMPAPAY 1794
>XP_005269721
          Length = 2073

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNLM APAY
Sbjct: 1969 VNLMPAPAY 1977
>NP_001092882
          Length = 2004

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VNLMSAPAY 9
            VNLM  PAY
Sbjct: 1901 VNLMPTPAY 1909
>NP_006757
          Length = 2004

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VNLMSAPAY 9
            VNLM  PAY
Sbjct: 1901 VNLMPTPAY 1909
>NP_001092883
          Length = 2004

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VNLMSAPAY 9
            VNLM  PAY
Sbjct: 1901 VNLMPTPAY 1909
>XP_005273706
          Length = 1997

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VNLMSAPAY 9
            VNLM  PAY
Sbjct: 1894 VNLMPTPAY 1902
>NP_001157576
          Length = 1165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LMSAPAY 9
           LMS PAY
Sbjct: 941 LMSRPAY 947
>NP_001157577
          Length = 1165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LMSAPAY 9
           LMS PAY
Sbjct: 921 LMSRPAY 927
>NP_061868
          Length = 1211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LMSAPAY 9
           LMS PAY
Sbjct: 941 LMSRPAY 947
>NP_001157578
          Length = 338

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  LMSAPAY 9
          LMS PAY
Sbjct: 68 LMSRPAY 74
>XP_005261981
          Length = 970

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LMSAPAY 9
           LMS PAY
Sbjct: 700 LMSRPAY 706
>XP_006724481
          Length = 1164

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LMSAPAY 9
           LMS PAY
Sbjct: 894 LMSRPAY 900
>XP_005261980
          Length = 1191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LMSAPAY 9
           LMS PAY
Sbjct: 921 LMSRPAY 927
>NP_000431
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NLMSAPA 8
           N+M+APA
Sbjct: 358 NIMNAPA 364
>NP_006195
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NLMSAPA 8
           N+M+APA
Sbjct: 360 NMMNAPA 366
>NP_064506
          Length = 1516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LMSAPAY 9
           +MSAP Y
Sbjct: 320 IMSAPVY 326
>NP_001139686
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NLMSAPAY 9
           NL+  PAY
Sbjct: 216 NLLDEPAY 223
>NP_001139685
          Length = 674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NLMSAPAY 9
           NL+  PAY
Sbjct: 208 NLLDEPAY 215
>NP_073608
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NLMSAPAY 9
           NL+  PAY
Sbjct: 208 NLLDEPAY 215
>NP_055108
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VNLMSAPA 8
           VNL +APA
Sbjct: 215 VNLSAAPA 222
>XP_006719629
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NLMSAPAY 9
           NL+  PAY
Sbjct: 109 NLLDEPAY 116
>XP_006719628
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NLMSAPAY 9
           NL+  PAY
Sbjct: 199 NLLDEPAY 206
>XP_006719627
          Length = 699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NLMSAPAY 9
           NL+  PAY
Sbjct: 216 NLLDEPAY 223
>XP_006719626
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NLMSAPAY 9
           NL+  PAY
Sbjct: 230 NLLDEPAY 237
>NP_000775
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VNLMSAP 7
           VNL SAP
Sbjct: 106 VNLASAP 112
>NP_001140
          Length = 1001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 107 VNLVSSPIH 115
>NP_001191332
          Length = 1861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 967 VNLVSSPIH 975
>NP_001191333
          Length = 1868

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 974 VNLVSSPIH 982
>NP_066267
          Length = 4377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 973 VNLVSSPIH 981
>NP_001032961
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            +NL++ PA+
Sbjct: 1004 INLIALPAF 1012
>NP_057400
          Length = 1251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            +NL++ PA+
Sbjct: 1005 INLIALPAF 1013
>NP_001139187
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VNLMSAP 7
           VNL++AP
Sbjct: 416 VNLLTAP 422
>XP_006724219
          Length = 1157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VNLMSAP 7
           +NL+SAP
Sbjct: 518 LNLLSAP 524
>XP_006724218
          Length = 1200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VNLMSAP 7
           +NL+SAP
Sbjct: 596 LNLLSAP 602
>XP_006724217
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VNLMSAP 7
           +NL+SAP
Sbjct: 596 LNLLSAP 602
>XP_005269773
          Length = 1867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 973 VNLVSSPIH 981
>XP_006717866
          Length = 1877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 991 VNLVSSPIH 999
>XP_005269772
          Length = 1885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 991 VNLVSSPIH 999
>XP_006717865
          Length = 1898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717864
          Length = 1924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717863
          Length = 1972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717862
          Length = 1981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717861
          Length = 1984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717860
          Length = 1993

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717859
          Length = 2758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717858
          Length = 2775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717857
          Length = 2794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717856
          Length = 2833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717855
          Length = 2837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717854
          Length = 2852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717853
          Length = 2854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            VNL+S+P +
Sbjct: 995  VNLVSSPIH 1003
>XP_006717852
          Length = 3508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 102 VNLVSSPIH 110
>XP_006717851
          Length = 3513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 107 VNLVSSPIH 115
>XP_006717850
          Length = 4364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 958 VNLVSSPIH 966
>XP_006717849
          Length = 4383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 977 VNLVSSPIH 985
>XP_006717848
          Length = 4392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 986 VNLVSSPIH 994
>XP_006717847
          Length = 4395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 989 VNLVSSPIH 997
>XP_006717846
          Length = 4396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 990 VNLVSSPIH 998
>XP_006717845
          Length = 4397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           VNL+S+P +
Sbjct: 991 VNLVSSPIH 999
>XP_006716050
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VNLMSAP 7
           VNL++AP
Sbjct: 416 VNLLTAP 422
>XP_006712656
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           +NL++ PA+
Sbjct: 515 INLIALPAF 523
>XP_005264025
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VNLMSAPAY 9
           +NL++ PA+
Sbjct: 935 INLIALPAF 943
>XP_006712655
          Length = 1251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    VNLMSAPAY 9
            +NL++ PA+
Sbjct: 1005 INLIALPAF 1013
>NP_777557
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LMSAPA 8
           LMSAPA
Sbjct: 207 LMSAPA 212
>NP_689726
          Length = 1274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VNLMSAP 7
           +NL+SAP
Sbjct: 635 LNLLSAP 641
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.124    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 570,026
Number of extensions: 564
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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