Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              21     229
XP_006718908                                                           21     229
XP_005271621                                                           21     229
XP_006718907                                                           21     229
XP_006718906                                                           21     229
XP_005271619                                                           21     229
XP_005271618                                                           21     229
NP_062823                                                              18    1935
XP_006723348                                                           18    1935
XP_006723347                                                           18    1935
NP_004251                                                              17    2528
NP_066010                                                              17    3301
NP_036376                                                              17    3301
NP_076945                                                              17    4312
XP_005270204                                                           17    4312
NP_001070665                                                           16    7355
NP_058649                                                              16    7355
NP_060140                                                              16    7355
NP_057565                                                              16    7355
NP_002174                                                              16    7355
NP_001254642                                                           16    7355
NP_001017981                                                           16    7355
XP_005274838                                                           16    7355
XP_005274837                                                           16    7355
XP_005274489                                                           16    7355
XP_005274488                                                           16    7355
XP_006720778                                                           16    7355
XP_006720777                                                           16    7355
XP_006720776                                                           16    7355
XP_006720775                                                           16    7355
XP_005252107                                                           16    7355
XP_005252106                                                           16    7355
XP_005252105                                                           16    7355
XP_005252104                                                           16    7355
XP_006712096                                                           16    7355
XP_006712095                                                           16    7355
XP_005264430                                                           16    7355
XP_006712094                                                           16    7355
XP_006712093                                                           16    7355
XP_005264429                                                           16    7355
NP_060022                                                              16    7355
NP_001229267                                                           16    7355
NP_001017420                                                           15    9605
NP_055816                                                              15    9605
NP_001010870                                                           15    9605
NP_001161831                                                           15    9605
NP_079037                                                              15    9605
XP_006716360                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VMQQVFPMC 9
            VMQQVF MC
Sbjct: 2727 VMQQVFQMC 2735
>XP_006718908
          Length = 1708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VMQQVFPMC 9
            VMQQVF MC
Sbjct: 1379 VMQQVFQMC 1387
>XP_005271621
          Length = 2708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VMQQVFPMC 9
            VMQQVF MC
Sbjct: 2379 VMQQVFQMC 2387
>XP_006718907
          Length = 3050

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VMQQVFPMC 9
            VMQQVF MC
Sbjct: 2721 VMQQVFQMC 2729
>XP_006718906
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VMQQVFPMC 9
            VMQQVF MC
Sbjct: 2727 VMQQVFQMC 2735
>XP_005271619
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VMQQVFPMC 9
            VMQQVF MC
Sbjct: 2727 VMQQVFQMC 2735
>XP_005271618
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VMQQVFPMC 9
            VMQQVF MC
Sbjct: 2727 VMQQVFQMC 2735
>NP_062823
          Length = 523

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMQQVFPMC 9
           V+Q VFP C
Sbjct: 146 VLQPVFPNC 154
>XP_006723348
          Length = 394

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VMQQVFPMC 9
          V+Q VFP C
Sbjct: 17 VLQPVFPNC 25
>XP_006723347
          Length = 444

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMQQVFPMC 9
           V+Q VFP C
Sbjct: 146 VLQPVFPNC 154
>NP_004251
          Length = 1208

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VMQQVFPMC 9
           ++Q+VFP C
Sbjct: 845 LVQRVFPAC 853
>NP_066010
          Length = 1232

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VMQQVFPM 8
           ++QQVFP+
Sbjct: 204 IIQQVFPV 211
>NP_036376
          Length = 535

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VMQQVFPMC 9
           V+Q +FP C
Sbjct: 146 VLQPLFPTC 154
>NP_076945
          Length = 287

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VMQQVFPMC 9
           V+ +VFP C
Sbjct: 151 VLLEVFPTC 159
>XP_005270204
          Length = 287

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VMQQVFPMC 9
           V+ +VFP C
Sbjct: 151 VLLEVFPTC 159
>NP_001070665
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   VMQQVFPMC 9
           VMQ   P C
Sbjct: 108 VMQMYLPFC 116
>NP_058649
          Length = 933

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   VMQQVFPMC 9
           VMQ   P C
Sbjct: 358 VMQMYLPFC 366
>NP_060140
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QQVFPMC 9
           Q+V PMC
Sbjct: 206 QEVEPMC 212
>NP_057565
          Length = 441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   MQQVFPM 8
           +QQ FPM
Sbjct: 240 IQQAFPM 246
>NP_002174
          Length = 378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           VMQ++FP
Sbjct: 330 VMQRLFP 336
>NP_001254642
          Length = 300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           VMQ++FP
Sbjct: 252 VMQRLFP 258
>NP_001017981
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VMQQVFPMC 9
           ++QQ  P+C
Sbjct: 357 MLQQTCPLC 365
>XP_005274838
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           VMQ++FP
Sbjct: 329 VMQRLFP 335
>XP_005274837
          Length = 378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           VMQ++FP
Sbjct: 330 VMQRLFP 336
>XP_005274489
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           VMQ++FP
Sbjct: 329 VMQRLFP 335
>XP_005274488
          Length = 378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           VMQ++FP
Sbjct: 330 VMQRLFP 336
>XP_006720778
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  VMQQVFP 7
          V QQVFP
Sbjct: 72 VHQQVFP 78
>XP_006720777
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VMQQVFP 7
           V QQVFP
Sbjct: 106 VHQQVFP 112
>XP_006720776
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VMQQVFP 7
           V QQVFP
Sbjct: 189 VHQQVFP 195
>XP_006720775
          Length = 497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VMQQVFP 7
           V QQVFP
Sbjct: 311 VHQQVFP 317
>XP_005252107
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   MQQVFPM 8
           +QQ FPM
Sbjct: 94  IQQAFPM 100
>XP_005252106
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   MQQVFPM 8
           +QQ FPM
Sbjct: 94  IQQAFPM 100
>XP_005252105
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   MQQVFPM 8
           +QQ FPM
Sbjct: 94  IQQAFPM 100
>XP_005252104
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   MQQVFPM 8
           +QQ FPM
Sbjct: 240 IQQAFPM 246
>XP_006712096
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VMQQVFP 7
          V+Q+VFP
Sbjct: 37 VLQKVFP 43
>XP_006712095
          Length = 849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           V+Q+VFP
Sbjct: 707 VLQKVFP 713
>XP_005264430
          Length = 1044

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           V+Q+VFP
Sbjct: 279 VLQKVFP 285
>XP_006712094
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           V+Q+VFP
Sbjct: 707 VLQKVFP 713
>XP_006712093
          Length = 1460

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           V+Q+VFP
Sbjct: 707 VLQKVFP 713
>XP_005264429
          Length = 1472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           V+Q+VFP
Sbjct: 707 VLQKVFP 713
>NP_060022
          Length = 1458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           V+Q+VFP
Sbjct: 693 VLQKVFP 699
>NP_001229267
          Length = 1453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMQQVFP 7
           V+Q+VFP
Sbjct: 693 VLQKVFP 699
>NP_001017420
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   QQVFPMC 9
           QQV P C
Sbjct: 466 QQVVPKC 472
>NP_055816
          Length = 3664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 4    QVFPMC 9
            Q+FP C
Sbjct: 3627 QIFPPC 3632
>NP_001010870
          Length = 2096

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1    VMQQVFPMC 9
            V  Q FP C
Sbjct: 1627 VPMQAFPCC 1635
>NP_001161831
          Length = 2066

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1    VMQQVFPMC 9
            V  Q FP C
Sbjct: 1627 VPMQAFPCC 1635
>NP_079037
          Length = 216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 3   QQVFPMC 9
           +++FP C
Sbjct: 132 EEIFPTC 138
>XP_006716360
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   QQVFPMC 9
           QQV P C
Sbjct: 466 QQVVPKC 472
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.347    0.141    0.509 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 499,575
Number of extensions: 600
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.8 bits)
S2: 28 (15.4 bits)

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