Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              19     665
XP_006717990                                                           19     665
XP_006717989                                                           19     665
NP_060555                                                              17    2528
XP_006711503                                                           17    2528
NP_116016                                                              17    3301
NP_001009998                                                           17    3301
NP_001243665                                                           17    3301
NP_036578                                                              17    3301
NP_001243663                                                           17    3301
NP_001243664                                                           17    3301
NP_001243662                                                           17    3301
NP_001009955                                                           17    3301
NP_663768                                                              17    3301
NP_001243661                                                           17    3301
NP_060540                                                              17    3301
XP_005259847                                                           17    3301
XP_006722731                                                           17    3301
XP_006722730                                                           17    3301
XP_006722729                                                           17    3301
XP_006722728                                                           17    3301
XP_005270770                                                           17    3301
XP_006710608                                                           17    3301
NP_000756                                                              17    4312
NP_001243426                                                           17    4312
NP_008908                                                              17    4312
NP_065912                                                              17    4312
NP_112207                                                              17    4312
NP_852100                                                              17    4312
XP_006720315                                                           17    4312
XP_006720314                                                           17    4312
XP_005268109                                                           17    4312
XP_005268110                                                           17    4312
XP_005268108                                                           17    4312
XP_006720313                                                           17    4312
XP_005268106                                                           17    4312
XP_005267133                                                           17    4312
NP_005551                                                              16    5631
XP_006723861                                                           16    5631
XP_006723860                                                           16    5631
XP_006723859                                                           16    5631
NP_005104                                                              16    7355
NP_078863                                                              16    7355
NP_006334                                                              16    7355
NP_001189784                                                           16    7355
NP_059488                                                              16    7355
NP_001191006                                                           16    7355
NP_004779                                                              16    7355
NP_003571                                                              16    7355
NP_001138244                                                           16    7355
XP_005263622                                                           16    7355
XP_005271253                                                           16    7355
XP_005271252                                                           16    7355
XP_005271251                                                           16    7355
NP_001005237                                                           16    7355
NP_005996                                                              15    9605
NP_001139325                                                           15    9605
NP_006132                                                              15    9605
NP_060101                                                              15    9605
NP_059129                                                              15    9605
NP_001159711                                                           15    9605
NP_006560                                                              15    9605
NP_001159712                                                           15    9605
NP_079011                                                              15    9605
NP_001273086                                                           15    9605
>NP_000305
          Length = 403

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMIYAYLLH 9
           VMI AYLLH
Sbjct: 133 VMICAYLLH 141
>XP_006717990
          Length = 175

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMIYAYLLH 9
           VMI AYLLH
Sbjct: 118 VMICAYLLH 126
>XP_006717989
          Length = 388

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMIYAYLLH 9
           VMI AYLLH
Sbjct: 118 VMICAYLLH 126
>NP_060555
          Length = 1041

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   VMIYAYLLH 9
           +M++A+L+H
Sbjct: 806 IMVFAHLVH 814
>XP_006711503
          Length = 860

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   VMIYAYLLH 9
           +M++A+L+H
Sbjct: 625 IMVFAHLVH 633
>NP_116016
          Length = 385

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 25 VYEYLLH 31
>NP_001009998
          Length = 363

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 25 VYEYLLH 31
>NP_001243665
          Length = 298

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 26 VYEYLLH 32
>NP_036578
          Length = 361

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 26 VYEYLLH 32
>NP_001243663
          Length = 339

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 26 VYEYLLH 32
>NP_001243664
          Length = 331

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 26 VYEYLLH 32
>NP_001243662
          Length = 341

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 26 VYEYLLH 32
>NP_001009955
          Length = 361

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 24 VYEYLLH 30
>NP_663768
          Length = 388

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 24 VYEYLLH 30
>NP_001243661
          Length = 369

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 26 VYEYLLH 32
>NP_060540
          Length = 368

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 24 VYEYLLH 30
>XP_005259847
          Length = 407

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 47 VYEYLLH 53
>XP_006722731
          Length = 413

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 25 VYEYLLH 31
>XP_006722730
          Length = 435

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 47 VYEYLLH 53
>XP_006722729
          Length = 435

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 25 VYEYLLH 31
>XP_006722728
          Length = 457

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 47 VYEYLLH 53
>XP_005270770
          Length = 369

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 24 VYEYLLH 30
>XP_006710608
          Length = 341

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  IYAYLLH 9
          +Y YLLH
Sbjct: 24 VYEYLLH 30
>NP_000756
          Length = 503

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VMIYAYLLH 9
           VMI +Y+LH
Sbjct: 394 VMIPSYVLH 402
>NP_001243426
          Length = 535

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VMIYAYLLH 9
           VMI +Y+LH
Sbjct: 394 VMIPSYVLH 402
>NP_008908
          Length = 435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IYAYLLH 9
          I++YLLH
Sbjct: 72 IFSYLLH 78
>NP_065912
          Length = 514

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IYAYLLH 9
          I++YLLH
Sbjct: 72 IFSYLLH 78
>NP_112207
          Length = 246

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IYAYLLH 9
           +Y YL+H
Sbjct: 178 VYVYLMH 184
>NP_852100
          Length = 319

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   IYAYLLH 9
           +Y YL+H
Sbjct: 251 VYVYLMH 257
>XP_006720315
          Length = 435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IYAYLLH 9
          I++YLLH
Sbjct: 72 IFSYLLH 78
>XP_006720314
          Length = 435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IYAYLLH 9
          I++YLLH
Sbjct: 72 IFSYLLH 78
>XP_005268109
          Length = 435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IYAYLLH 9
          I++YLLH
Sbjct: 72 IFSYLLH 78
>XP_005268110
          Length = 435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IYAYLLH 9
          I++YLLH
Sbjct: 72 IFSYLLH 78
>XP_005268108
          Length = 457

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYAYLLH 9
           I++YLLH
Sbjct: 94  IFSYLLH 100
>XP_006720313
          Length = 506

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYAYLLH 9
           I++YLLH
Sbjct: 197 IFSYLLH 203
>XP_005268106
          Length = 560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYAYLLH 9
           I++YLLH
Sbjct: 197 IFSYLLH 203
>XP_005267133
          Length = 514

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IYAYLLH 9
          I++YLLH
Sbjct: 72 IFSYLLH 78
>NP_005551
          Length = 3695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    YAYLLH 9
            YA+LLH
Sbjct: 1299 YAFLLH 1304
>XP_006723861
          Length = 2300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    YAYLLH 9
            YA+LLH
Sbjct: 1299 YAFLLH 1304
>XP_006723860
          Length = 2586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    YAYLLH 9
            YA+LLH
Sbjct: 1299 YAFLLH 1304
>XP_006723859
          Length = 3700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    YAYLLH 9
            YA+LLH
Sbjct: 1299 YAFLLH 1304
>NP_005104
          Length = 731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMIYAYLLH 9
           V+IY  LLH
Sbjct: 701 VIIYMALLH 709
>NP_078863
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VMIYAYLL 8
           VM+Y Y+L
Sbjct: 117 VMLYRYVL 124
>NP_006334
          Length = 999

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IYAYLLH 9
           +Y YLLH
Sbjct: 809 MYDYLLH 815
>NP_001189784
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMIYAYLLH 9
           VMI +Y LH
Sbjct: 393 VMIPSYALH 401
>NP_059488
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMIYAYLLH 9
           VMI +Y LH
Sbjct: 394 VMIPSYALH 402
>NP_001191006
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VMIYAYL 7
           +++YAYL
Sbjct: 288 ILLYAYL 294
>NP_004779
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VMIYAYL 7
           +++YAYL
Sbjct: 295 ILLYAYL 301
>NP_003571
          Length = 917

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   YAYLLH 9
           Y YLLH
Sbjct: 313 YQYLLH 318
>NP_001138244
          Length = 948

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   YAYLLH 9
           Y YLLH
Sbjct: 344 YQYLLH 349
>XP_005263622
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IYAYLLH 9
           +Y YLLH
Sbjct: 809 MYDYLLH 815
>XP_005271253
          Length = 204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  VMIYAYLL 8
          VM+Y Y+L
Sbjct: 44 VMLYRYVL 51
>XP_005271252
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  VMIYAYLL 8
          VM+Y Y+L
Sbjct: 86 VMLYRYVL 93
>XP_005271251
          Length = 247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  VMIYAYLL 8
          VM+Y Y+L
Sbjct: 87 VMLYRYVL 94
>NP_001005237
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VMIYAYLLH 9
           V+ +AY LH
Sbjct: 175 VLAHAYCLH 183
>NP_005996
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MIYAYLLH 9
           ++Y YLL+
Sbjct: 506 LLYVYLLY 513
>NP_001139325
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MIYAYLLH 9
           ++Y YLL+
Sbjct: 506 LLYVYLLY 513
>NP_006132
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 2   MIYAYLLH 9
           ++Y Y++H
Sbjct: 282 LLYKYIVH 289
>NP_060101
          Length = 1712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IYAYLL 8
           +YAYLL
Sbjct: 185 LYAYLL 190
>NP_059129
          Length = 1616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4    YAYLLH 9
            Y YLLH
Sbjct: 1510 YYYLLH 1515
>NP_001159711
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  VMIYAYLLH 9
          V++Y + LH
Sbjct: 73 VLLYLFALH 81
>NP_006560
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  VMIYAYLLH 9
          V++Y + LH
Sbjct: 73 VLLYLFALH 81
>NP_001159712
          Length = 132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  VMIYAYLLH 9
          V++Y + LH
Sbjct: 73 VLLYLFALH 81
>NP_079011
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IYAYLLH 9
           +YA LLH
Sbjct: 134 VYAKLLH 140
>NP_001273086
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 2   MIYAYLLH 9
           ++Y Y++H
Sbjct: 205 LLYKYIVH 212
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.348    0.154    0.485 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 416,267
Number of extensions: 620
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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