Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              19     869
XP_006716142                                                           19     869
XP_005250088                                                           19     869
XP_006716141                                                           19     869
XP_005250085                                                           19     869
XP_006716140                                                           19     869
XP_005250084                                                           19     869
XP_005250083                                                           19     869
XP_005250082                                                           19     869
NP_569713                                                              16    5631
NP_001078921                                                           16    7355
NP_004954                                                              16    7355
NP_254273                                                              16    7355
NP_001139644                                                           16    7355
NP_006828                                                              16    7355
NP_001139645                                                           16    7355
NP_001159609                                                           16    7355
NP_001076593                                                           16    7355
XP_006717297                                                           16    7355
XP_005272574                                                           16    7355
NP_001138596                                                           16    7355
NP_001138668                                                           16    7355
NP_002793                                                              16    7355
NP_059111                                                              15    9605
NP_001244123                                                           15    9605
NP_001244124                                                           15    9605
NP_006624                                                              15    9605
NP_001272389                                                           15    9605
NP_443163                                                              15    9605
NP_001171643                                                           15    9605
NP_001154994                                                           15    9605
NP_009177                                                              15    9605
NP_001154993                                                           15    9605
XP_005248470                                                           15    9605
XP_006714585                                                           15    9605
XP_005248468                                                           15    9605
XP_005248467                                                           15    9605
XP_005248466                                                           15    9605
XP_005262767                                                           15    9605
XP_006714137                                                           15    9605
>NP_733751
          Length = 4911

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMESVALPL 9
           VMESV LPL
Sbjct: 688 VMESVTLPL 696
>XP_006716142
          Length = 4927

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMESVALPL 9
           VMESV LPL
Sbjct: 689 VMESVTLPL 697
>XP_005250088
          Length = 4928

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMESVALPL 9
           VMESV LPL
Sbjct: 689 VMESVTLPL 697
>XP_006716141
          Length = 4959

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMESVALPL 9
           VMESV LPL
Sbjct: 689 VMESVTLPL 697
>XP_005250085
          Length = 4979

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMESVALPL 9
           VMESV LPL
Sbjct: 689 VMESVTLPL 697
>XP_006716140
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMESVALPL 9
           VMESV LPL
Sbjct: 689 VMESVTLPL 697
>XP_005250084
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMESVALPL 9
           VMESV LPL
Sbjct: 689 VMESVTLPL 697
>XP_005250083
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMESVALPL 9
           VMESV LPL
Sbjct: 688 VMESVTLPL 696
>XP_005250082
          Length = 4983

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VMESVALPL 9
           VMESV LPL
Sbjct: 689 VMESVTLPL 697
>NP_569713
          Length = 621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VMESVALPL 9
           V+E+V LPL
Sbjct: 257 VLENVRLPL 265
>NP_001078921
          Length = 1361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESVALPL 9
           +SVALPL
Sbjct: 255 DSVALPL 261
>NP_004954
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   MESVALPL 9
           MES  LPL
Sbjct: 953 MESTGLPL 960
>NP_254273
          Length = 289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VMESVALPL 9
          + ES++LPL
Sbjct: 34 LQESISLPL 42
>NP_001139644
          Length = 198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VMESVALPL 9
          + ES++LPL
Sbjct: 34 LQESISLPL 42
>NP_006828
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VMESVALPL 9
           +M+S ALP+
Sbjct: 92  IMDSFALPV 100
>NP_001139645
          Length = 111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VMESVALPL 9
          + ES++LPL
Sbjct: 34 LQESISLPL 42
>NP_001159609
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESVALPL 9
           +SVALPL
Sbjct: 247 DSVALPL 253
>NP_001076593
          Length = 1347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESVALPL 9
           +SVALPL
Sbjct: 241 DSVALPL 247
>XP_006717297
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESVALPL 9
           +SVALPL
Sbjct: 247 DSVALPL 253
>XP_005272574
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESVALPL 9
           +SVALPL
Sbjct: 253 DSVALPL 259
>NP_001138596
          Length = 1188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESVALPL 9
           +SVALPL
Sbjct: 253 DSVALPL 259
>NP_001138668
          Length = 1343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESVALPL 9
           +SVALPL
Sbjct: 241 DSVALPL 247
>NP_002793
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMESVALPL 9
           + ESV LPL
Sbjct: 197 IKESVELPL 205
>NP_059111
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMESVALPL 9
           +ME V LPL
Sbjct: 235 LMEHVRLPL 243
>NP_001244123
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMESVALPL 9
           +ME V LPL
Sbjct: 203 LMEHVRLPL 211
>NP_001244124
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMESVALPL 9
           +ME V LPL
Sbjct: 153 LMEHVRLPL 161
>NP_006624
          Length = 1575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   MESVALP 8
           MES+ LP
Sbjct: 120 MESIGLP 126
>NP_001272389
          Length = 1525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  MESVALP 8
          MES+ LP
Sbjct: 70 MESIGLP 76
>NP_443163
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ESVALPL 9
          ESV LPL
Sbjct: 36 ESVTLPL 42
>NP_001171643
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  ESVALPL 9
          ESV LPL
Sbjct: 36 ESVTLPL 42
>NP_001154994
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMESVALPL 9
           +ME V LPL
Sbjct: 153 LMEHVRLPL 161
>NP_009177
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMESVALPL 9
           +ME V LPL
Sbjct: 241 LMEHVRLPL 249
>NP_001154993
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMESVALPL 9
           +ME V LPL
Sbjct: 245 LMEHVRLPL 253
>XP_005248470
          Length = 1518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   MESVALP 8
           MES+ LP
Sbjct: 120 MESIGLP 126
>XP_006714585
          Length = 1525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  MESVALP 8
          MES+ LP
Sbjct: 70 MESIGLP 76
>XP_005248468
          Length = 1548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  MESVALP 8
          MES+ LP
Sbjct: 93 MESIGLP 99
>XP_005248467
          Length = 1548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  MESVALP 8
          MES+ LP
Sbjct: 93 MESIGLP 99
>XP_005248466
          Length = 1565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   MESVALP 8
           MES+ LP
Sbjct: 110 MESIGLP 116
>XP_005262767
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMESVALPL 9
           +ME V LPL
Sbjct: 153 LMEHVRLPL 161
>XP_006714137
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VMESVALPL 9
           +ME V LPL
Sbjct: 241 LMEHVRLPL 249
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.132    0.336 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,707
Number of extensions: 739
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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