Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           19     665
NP_004561                                                              19     665
NP_001275703                                                           19     665
XP_005253450                                                           19     665
XP_006719151                                                           19     665
NP_006648                                                              17    3301
NP_996848                                                              17    3301
XP_006724024                                                           17    3301
NP_001005329                                                           17    3301
NP_001004748                                                           17    3301
NP_689914                                                              17    4312
XP_006720120                                                           17    4312
XP_006720119                                                           17    4312
NP_689659                                                              17    4312
NP_775184                                                              16    5631
NP_751945                                                              16    5631
NP_001241681                                                           16    5631
NP_001029288                                                           16    5631
NP_115945                                                              16    5631
NP_056451                                                              16    5631
NP_689562                                                              16    5631
NP_060862                                                              16    5631
XP_006716715                                                           16    5631
XP_005263172                                                           16    5631
XP_006712195                                                           16    5631
XP_005264689                                                           16    5631
NP_996879                                                              16    7355
NP_065433                                                              16    7355
NP_001136123                                                           16    7355
NP_065749                                                              16    7355
NP_071338                                                              16    7355
NP_001014980                                                           16    7355
XP_005269098                                                           16    7355
XP_005269097                                                           16    7355
XP_005269096                                                           16    7355
XP_006717983                                                           16    7355
XP_005270036                                                           16    7355
XP_005270035                                                           16    7355
XP_006710494                                                           16    7355
XP_006710492                                                           16    7355
XP_006710491                                                           16    7355
XP_006710490                                                           16    7355
XP_006710489                                                           16    7355
NP_942090                                                              16    7355
NP_001004749                                                           16    7355
NP_115785                                                              15    9605
NP_079472                                                              15    9605
NP_071942                                                              15    9605
NP_001004485                                                           15    9605
>NP_001275701
          Length = 1486

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VLVCVETKQ 9
           VL CVETKQ
Sbjct: 440 VLGCVETKQ 448
>NP_004561
          Length = 1445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VLVCVETKQ 9
           VL CVETKQ
Sbjct: 440 VLGCVETKQ 448
>NP_001275703
          Length = 1264

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VLVCVETKQ 9
           VL CVETKQ
Sbjct: 218 VLGCVETKQ 226
>XP_005253450
          Length = 1486

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VLVCVETKQ 9
           VL CVETKQ
Sbjct: 440 VLGCVETKQ 448
>XP_006719151
          Length = 1486

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VLVCVETKQ 9
           VL CVETKQ
Sbjct: 440 VLGCVETKQ 448
>NP_006648
          Length = 541

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLVCVETKQ 9
           VL C+ET+Q
Sbjct: 532 VLDCLETRQ 540
>NP_996848
          Length = 541

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLVCVETKQ 9
           VL C+ET+Q
Sbjct: 532 VLDCLETRQ 540
>XP_006724024
          Length = 584

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLVCVETKQ 9
           VL C+ET+Q
Sbjct: 575 VLDCLETRQ 583
>NP_001005329
          Length = 313

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLVCVETKQ 9
           ++ CV+TKQ
Sbjct: 291 IVYCVKTKQ 299
>NP_001004748
          Length = 313

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLVCVETKQ 9
           ++ CV+TKQ
Sbjct: 291 IVYCVKTKQ 299
>NP_689914
          Length = 5058

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLVCVET 7
           VL+C+ET
Sbjct: 465 VLICLET 471
>XP_006720120
          Length = 1055

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LVCVETKQ 9
           L+C+ET+Q
Sbjct: 778 LLCLETEQ 785
>XP_006720119
          Length = 1094

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LVCVETKQ 9
           L+C+ET+Q
Sbjct: 817 LLCLETEQ 824
>NP_689659
          Length = 1094

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LVCVETKQ 9
           L+C+ET+Q
Sbjct: 817 LLCLETEQ 824
>NP_775184
          Length = 152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVCVETKQ 9
          L CVET++
Sbjct: 68 LACVETEE 75
>NP_751945
          Length = 543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VLVCVET 7
           VLVC ET
Sbjct: 454 VLVCCET 460
>NP_001241681
          Length = 140

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LVCVETKQ 9
           L C+ET+Q
Sbjct: 124 LNCIETRQ 131
>NP_001029288
          Length = 523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VLVCVET 7
           VLVC ET
Sbjct: 434 VLVCCET 440
>NP_115945
          Length = 152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVCVETKQ 9
          L CVET++
Sbjct: 68 LACVETEE 75
>NP_056451
          Length = 522

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VLVCVET 7
           VLVC ET
Sbjct: 433 VLVCCET 439
>NP_689562
          Length = 295

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   CVETKQ 9
           C+ETKQ
Sbjct: 262 CLETKQ 267
>NP_060862
          Length = 2104

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VLVCVETKQ 9
            +L CV T+Q
Sbjct: 2005 ILSCVRTRQ 2013
>XP_006716715
          Length = 161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LVCVETKQ 9
           L C+ET+Q
Sbjct: 124 LNCIETRQ 131
>XP_005263172
          Length = 2104

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VLVCVETKQ 9
            +L CV T+Q
Sbjct: 2005 ILSCVRTRQ 2013
>XP_006712195
          Length = 507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VLVCVET 7
           VLVC ET
Sbjct: 418 VLVCCET 424
>XP_005264689
          Length = 508

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VLVCVET 7
           VLVC ET
Sbjct: 419 VLVCCET 425
>NP_996879
          Length = 2223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    VCVETKQ 9
            +C+E+KQ
Sbjct: 1742 LCIESKQ 1748
>NP_065433
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VLVCVET 7
           +LVC+E+
Sbjct: 94  ILVCIES 100
>NP_001136123
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LVCVETKQ 9
           L+CV+T Q
Sbjct: 406 LLCVDTTQ 413
>NP_065749
          Length = 477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VLVCVET 7
           +LVCV T
Sbjct: 425 ILVCVST 431
>NP_071338
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VCVETKQ 9
           VCV T+Q
Sbjct: 400 VCVNTRQ 406
>NP_001014980
          Length = 302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VLVCVET 7
           VL+C+E+
Sbjct: 232 VLICIES 238
>XP_005269098
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VLVCVET 7
           +LVCV T
Sbjct: 394 ILVCVST 400
>XP_005269097
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VLVCVET 7
           +LVCV T
Sbjct: 394 ILVCVST 400
>XP_005269096
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VLVCVET 7
           +LVCV T
Sbjct: 394 ILVCVST 400
>XP_006717983
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVCVETKQ 9
          L+C +TKQ
Sbjct: 68 LLCEQTKQ 75
>XP_005270036
          Length = 1113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVCVETKQ 9
          L+C +TKQ
Sbjct: 68 LLCEQTKQ 75
>XP_005270035
          Length = 1189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVCVETKQ 9
          L+C +TKQ
Sbjct: 68 LLCEQTKQ 75
>XP_006710494
          Length = 1152

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VCVETKQ 9
           +C+E+KQ
Sbjct: 671 LCIESKQ 677
>XP_006710492
          Length = 1351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VCVETKQ 9
           +C+E+KQ
Sbjct: 870 LCIESKQ 876
>XP_006710491
          Length = 1496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    VCVETKQ 9
            +C+E+KQ
Sbjct: 1015 LCIESKQ 1021
>XP_006710490
          Length = 2158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    VCVETKQ 9
            +C+E+KQ
Sbjct: 1677 LCIESKQ 1683
>XP_006710489
          Length = 2185

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    VCVETKQ 9
            +C+E+KQ
Sbjct: 1704 LCIESKQ 1710
>NP_942090
          Length = 1189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVCVETKQ 9
          L+C +TKQ
Sbjct: 68 LLCEQTKQ 75
>NP_001004749
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLVCVETKQ 9
           ++ CV+T+Q
Sbjct: 289 IVYCVKTRQ 297
>NP_115785
          Length = 581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   CVETK 8
           CVETK
Sbjct: 549 CVETK 553
>NP_079472
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  LVCVETKQ 9
          L+C  TKQ
Sbjct: 26 LLCTATKQ 33
>NP_071942
          Length = 173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  VLVCVETK 8
          VLV VETK
Sbjct: 86 VLVDVETK 93
>NP_001004485
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LVCVET 7
           LVCV+T
Sbjct: 187 LVCVDT 192
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.133    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 654,406
Number of extensions: 784
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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