Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              20     390
NP_001035957                                                           20     390
XP_006721990                                                           20     390
XP_006721989                                                           20     390
XP_005258041                                                           20     390
XP_006721988                                                           20     390
XP_006721987                                                           20     390
XP_006721986                                                           20     390
XP_005258040                                                           20     390
XP_006721985                                                           20     390
NP_001186918                                                           17    2528
NP_005981                                                              17    3301
NP_000101                                                              17    4312
XP_006710460                                                           17    4312
XP_005270619                                                           17    4312
NP_001193499                                                           16    5631
NP_001013049                                                           16    5631
NP_001193501                                                           16    5631
NP_443150                                                              16    5631
NP_001193500                                                           16    5631
NP_001193498                                                           16    5631
NP_001035700                                                           16    5631
NP_078856                                                              16    5631
XP_005269532                                                           16    5631
NP_001182180                                                           16    7355
NP_778239                                                              16    7355
NP_001182181                                                           16    7355
NP_008825                                                              16    7355
NP_001153699                                                           16    7355
NP_001002294                                                           16    7355
NP_079413                                                              16    7355
NP_001182183                                                           16    7355
NP_001182178                                                           16    7355
NP_778243                                                              16    7355
NP_001182179                                                           16    7355
NP_001182177                                                           16    7355
NP_001027450                                                           16    7355
NP_005124                                                              16    7355
XP_006720764                                                           16    7355
XP_005254752                                                           16    7355
XP_006720763                                                           16    7355
XP_006720762                                                           16    7355
XP_005254751                                                           16    7355
XP_006716855                                                           16    7355
XP_006716854                                                           16    7355
XP_005245101                                                           16    7355
NP_000145                                                              15    9605
NP_001166                                                              15    9605
NP_000572                                                              15    9605
NP_000607                                                              15    9605
NP_001181943                                                           15    9605
NP_000043                                                              15    9605
NP_001269153                                                           15    9605
NP_005520                                                              15    9605
NP_002644                                                              15    9605
NP_001123553                                                           15    9605
NP_076991                                                              15    9605
NP_065772                                                              15    9605
NP_002653                                                              15    9605
NP_002074                                                              15    9605
XP_006724837                                                           15    9605
XP_005256858                                                           15    9605
XP_005247591                                                           15    9605
XP_005247590                                                           15    9605
XP_006710661                                                           15    9605
XP_005245920                                                           15    9605
XP_006710660                                                           15    9605
XP_006710659                                                           15    9605
XP_006710658                                                           15    9605
XP_006710657                                                           15    9605
>NP_000258
          Length = 2818

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLTDPKIQ 8
            VLTDPKIQ
Sbjct: 2588 VLTDPKIQ 2595
>NP_001035957
          Length = 2839

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLTDPKIQ 8
            VLTDPKIQ
Sbjct: 2609 VLTDPKIQ 2616
>XP_006721990
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLTDPKIQ 8
            VLTDPKIQ
Sbjct: 2619 VLTDPKIQ 2626
>XP_006721989
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLTDPKIQ 8
            VLTDPKIQ
Sbjct: 2619 VLTDPKIQ 2626
>XP_005258041
          Length = 2836

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLTDPKIQ 8
            VLTDPKIQ
Sbjct: 2588 VLTDPKIQ 2595
>XP_006721988
          Length = 2846

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLTDPKIQ 8
            VLTDPKIQ
Sbjct: 2598 VLTDPKIQ 2605
>XP_006721987
          Length = 2849

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLTDPKIQ 8
            VLTDPKIQ
Sbjct: 2619 VLTDPKIQ 2626
>XP_006721986
          Length = 2854

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLTDPKIQ 8
            VLTDPKIQ
Sbjct: 2606 VLTDPKIQ 2613
>XP_005258040
          Length = 2857

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLTDPKIQ 8
            VLTDPKIQ
Sbjct: 2609 VLTDPKIQ 2616
>XP_006721985
          Length = 2867

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLTDPKIQ 8
            VLTDPKIQ
Sbjct: 2619 VLTDPKIQ 2626
>NP_001186918
          Length = 122

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLTDPKIQV 9
           +LTDP+ QV
Sbjct: 93  ILTDPRHQV 101
>NP_005981
          Length = 968

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LTDPKIQV 9
           LT+P+IQV
Sbjct: 129 LTEPQIQV 136
>NP_000101
          Length = 1025

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLTDPKIQ 8
           VL+DPK++
Sbjct: 441 VLSDPKVK 448
>XP_006710460
          Length = 889

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLTDPKIQ 8
           VL+DPK++
Sbjct: 441 VLSDPKVK 448
>XP_005270619
          Length = 953

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLTDPKIQ 8
           VL+DPK++
Sbjct: 441 VLSDPKVK 448
>NP_001193499
          Length = 1130

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLTDPKIQ 8
           +LTDP+I+
Sbjct: 245 LLTDPEIE 252
>NP_001013049
          Length = 1198

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLTDPKIQ 8
           +LTDP+I+
Sbjct: 245 LLTDPEIE 252
>NP_001193501
          Length = 1179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLTDPKIQ 8
           +LTDP+I+
Sbjct: 245 LLTDPEIE 252
>NP_443150
          Length = 1168

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLTDPKIQ 8
           +LTDP+I+
Sbjct: 245 LLTDPEIE 252
>NP_001193500
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLTDPKIQ 8
           +LTDP+I+
Sbjct: 245 LLTDPEIE 252
>NP_001193498
          Length = 1179

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLTDPKIQ 8
           +LTDP+I+
Sbjct: 245 LLTDPEIE 252
>NP_001035700
          Length = 1069

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TDPKIQV 9
           +DPK+Q+
Sbjct: 284 SDPKVQI 290
>NP_078856
          Length = 1120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TDPKIQV 9
           +DPK+Q+
Sbjct: 335 SDPKVQI 341
>XP_005269532
          Length = 1068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLTDPKIQ 8
           +LTDP+I+
Sbjct: 245 LLTDPEIE 252
>NP_001182180
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTDPKIQV 9
           + DPK+QV
Sbjct: 175 MQDPKMQV 182
>NP_778239
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTDPKIQV 9
           + DPK+QV
Sbjct: 189 MQDPKMQV 196
>NP_001182181
          Length = 284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTDPKIQV 9
           + DPK+QV
Sbjct: 117 MQDPKMQV 124
>NP_008825
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LTDPKI 7
           LTDPK+
Sbjct: 452 LTDPKL 457
>NP_001153699
          Length = 2330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LTDPKI 7
            LTDPK+
Sbjct: 1047 LTDPKL 1052
>NP_001002294
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LTDPKI 7
           LTDPK+
Sbjct: 452 LTDPKL 457
>NP_079413
          Length = 2443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LTDPKI 7
            LTDPK+
Sbjct: 1047 LTDPKL 1052
>NP_001182183
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTDPKIQV 9
           + DPK+QV
Sbjct: 121 MQDPKMQV 128
>NP_001182178
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTDPKIQV 9
           + DPK+QV
Sbjct: 175 MQDPKMQV 182
>NP_778243
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTDPKIQV 9
           + DPK+QV
Sbjct: 175 MQDPKMQV 182
>NP_001182179
          Length = 302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTDPKIQV 9
           + DPK+QV
Sbjct: 135 MQDPKMQV 142
>NP_001182177
          Length = 356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTDPKIQV 9
           + DPK+QV
Sbjct: 189 MQDPKMQV 196
>NP_001027450
          Length = 225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LTDPKI 7
           LTDPK+
Sbjct: 198 LTDPKL 203
>NP_005124
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LTDPKI 7
           LTDPK+
Sbjct: 302 LTDPKL 307
>XP_006720764
          Length = 1584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LTDPKI 7
            LTDPK+
Sbjct: 1047 LTDPKL 1052
>XP_005254752
          Length = 2357

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LTDPKI 7
           LTDPK+
Sbjct: 961 LTDPKL 966
>XP_006720763
          Length = 2395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LTDPKI 7
            LTDPK+
Sbjct: 1047 LTDPKL 1052
>XP_006720762
          Length = 2397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LTDPKI 7
            LTDPK+
Sbjct: 1047 LTDPKL 1052
>XP_005254751
          Length = 2407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LTDPKI 7
            LTDPK+
Sbjct: 1047 LTDPKL 1052
>XP_006716855
          Length = 254

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LTDPKIQV 9
          + DPK+QV
Sbjct: 87 MQDPKMQV 94
>XP_006716854
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTDPKIQV 9
           + DPK+QV
Sbjct: 175 MQDPKMQV 182
>XP_005245101
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LTDPKI 7
           LTDPK+
Sbjct: 389 LTDPKL 394
>NP_000145
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTDPKIQV 9
           L+DPK+ V
Sbjct: 213 LSDPKLAV 220
>NP_001166
          Length = 201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  VLTDPK 6
          V+TDPK
Sbjct: 58 VVTDPK 63
>NP_000572
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VLTDPKI 7
           ++TDPK+
Sbjct: 143 LMTDPKL 149
>NP_000607
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLTDPKIQV 9
           V  DPK+Q+
Sbjct: 266 VTQDPKLQM 274
>NP_001181943
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VLTDPKIQV 9
          V  DPK+Q+
Sbjct: 87 VTQDPKLQM 95
>NP_000043
          Length = 1500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  VLTDPKIQ 8
          ++ DPK+Q
Sbjct: 50 IIYDPKLQ 57
>NP_001269153
          Length = 1422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  VLTDPKIQ 8
          ++ DPK+Q
Sbjct: 50 IIYDPKLQ 57
>NP_005520
          Length = 4391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LTDPKIQV 9
            L+DP +Q+
Sbjct: 1430 LSDPDVQI 1437
>NP_002644
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LTDPKIQV 9
           LT+P+++V
Sbjct: 128 LTEPRVRV 135
>NP_001123553
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  TDPKIQ 8
          +DPKIQ
Sbjct: 47 SDPKIQ 52
>NP_076991
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLTDPKIQ 8
           +LTD K+Q
Sbjct: 349 ILTDLKVQ 356
>NP_065772
          Length = 1709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LTDPKIQ 8
            LTDP+I+
Sbjct: 1026 LTDPQIR 1032
>NP_002653
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  TDPKIQ 8
          +DPKIQ
Sbjct: 47 SDPKIQ 52
>NP_002074
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VLTDPKI 7
           ++TDPK+
Sbjct: 133 LMTDPKL 139
>XP_006724837
          Length = 1533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LTDPKIQ 8
           LTDP+I+
Sbjct: 850 LTDPQIR 856
>XP_005256858
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLTDPKIQ 8
           +LTD K+Q
Sbjct: 131 ILTDLKVQ 138
>XP_005247591
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  TDPKIQ 8
          +DPKIQ
Sbjct: 47 SDPKIQ 52
>XP_005247590
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  TDPKIQ 8
          +DPKIQ
Sbjct: 47 SDPKIQ 52
>XP_006710661
          Length = 4057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LTDPKIQV 9
            L+DP +Q+
Sbjct: 1613 LSDPDVQI 1620
>XP_005245920
          Length = 4392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LTDPKIQV 9
            L+DP +Q+
Sbjct: 1431 LSDPDVQI 1438
>XP_006710660
          Length = 4397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LTDPKIQV 9
            L+DP +Q+
Sbjct: 1430 LSDPDVQI 1437
>XP_006710659
          Length = 4556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LTDPKIQV 9
            L+DP +Q+
Sbjct: 1589 LSDPDVQI 1596
>XP_006710658
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LTDPKIQV 9
            L+DP +Q+
Sbjct: 1596 LSDPDVQI 1603
>XP_006710657
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LTDPKIQV 9
            L+DP +Q+
Sbjct: 1612 LSDPDVQI 1619
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.140    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 741,915
Number of extensions: 919
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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