Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     665
NP_001075109                                                           19     665
NP_077017                                                              17    3301
NP_775901                                                              16    5631
XP_005266736                                                           16    5631
XP_006722498                                                           16    5631
XP_006722497                                                           16    5631
NP_000072                                                              16    7355
XP_005273087                                                           16    7355
XP_005273086                                                           16    7355
XP_005273085                                                           16    7355
XP_005273084                                                           16    7355
NP_001165088                                                           15    9605
NP_001165074                                                           15    9605
NP_001165077                                                           15    9605
NP_062552                                                              15    9605
NP_001035845                                                           15    9605
NP_006027                                                              15    9605
NP_001035844                                                           15    9605
NP_653285                                                              15    9605
NP_002009                                                              15    9605
NP_001243193                                                           15    9605
NP_001165084                                                           15    9605
NP_001269979                                                           15    9605
NP_001269980                                                           15    9605
NP_001269981                                                           15    9605
NP_056074                                                              15    9605
NP_001243194                                                           15    9605
XP_005261155                                                           15    9605
XP_006723963                                                           15    9605
XP_006723962                                                           15    9605
XP_006723081                                                           15    9605
XP_005256615                                                           15    9605
XP_005256613                                                           15    9605
XP_005256612                                                           15    9605
XP_005264717                                                           15    9605
XP_005264716                                                           15    9605
XP_005264715                                                           15    9605
XP_005264714                                                           15    9605
XP_005264712                                                           15    9605
XP_005264711                                                           15    9605
XP_006712215                                                           15    9605
XP_006712214                                                           15    9605
XP_005264710                                                           15    9605
XP_006710171                                                           15    9605
XP_006710170                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VLNSMLDQS 9
            VLN MLDQS
Sbjct: 1596 VLNGMLDQS 1604
>NP_001075109
          Length = 4097

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VLNSMLDQS 9
            VLN MLDQS
Sbjct: 1596 VLNGMLDQS 1604
>NP_077017
          Length = 83

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LNSMLDQ 8
          +NSMLDQ
Sbjct: 31 INSMLDQ 37
>NP_775901
          Length = 2226

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLNSMLDQS 9
            V+N +LDQS
Sbjct: 1418 VVNILLDQS 1426
>XP_005266736
          Length = 1314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLNSMLDQS 9
           V+N +LDQS
Sbjct: 506 VVNILLDQS 514
>XP_006722498
          Length = 2059

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLNSMLDQS 9
            V+N +LDQS
Sbjct: 1419 VVNILLDQS 1427
>XP_006722497
          Length = 2227

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLNSMLDQS 9
            V+N +LDQS
Sbjct: 1419 VVNILLDQS 1427
>NP_000072
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LNSMLDQS 9
          LNS++DQ+
Sbjct: 58 LNSIIDQA 65
>XP_005273087
          Length = 2788

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LNSMLDQS 9
          LNS++DQ+
Sbjct: 58 LNSIIDQA 65
>XP_005273086
          Length = 3264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LNSMLDQS 9
          LNS++DQ+
Sbjct: 58 LNSIIDQA 65
>XP_005273085
          Length = 3755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LNSMLDQS 9
          LNS++DQ+
Sbjct: 58 LNSIIDQA 65
>XP_005273084
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LNSMLDQS 9
          LNS++DQ+
Sbjct: 58 LNSIIDQA 65
>NP_001165088
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 499 VLNTMMD 505
>NP_001165074
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 588 VLNTMMD 594
>NP_001165077
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 588 VLNTMMD 594
>NP_062552
          Length = 689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LNSMLDQ 8
           LNS+LD+
Sbjct: 197 LNSLLDE 203
>NP_001035845
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 522 VLNTMMD 528
>NP_006027
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 588 VLNTMMD 594
>NP_001035844
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 526 VLNTMMD 532
>NP_653285
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LNSMLDQ 8
          +NSML+Q
Sbjct: 75 INSMLEQ 81
>NP_002009
          Length = 1269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VLNSMLDQS 9
            +LN+M D S
Sbjct: 1120 ILNTMFDTS 1128
>NP_001243193
          Length = 1258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VLNSMLDQS 9
            +LN+M D S
Sbjct: 1109 ILNTMFDTS 1117
>NP_001165084
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 499 VLNTMMD 505
>NP_001269979
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMLDQS 9
           NS+LDQ+
Sbjct: 177 NSLLDQA 183
>NP_001269980
          Length = 185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  NSMLDQS 9
          NS+LDQ+
Sbjct: 60 NSLLDQA 66
>NP_001269981
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  NSMLDQS 9
          NS+LDQ+
Sbjct: 92 NSLLDQA 98
>NP_056074
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMLDQS 9
           NS+LDQ+
Sbjct: 177 NSLLDQA 183
>NP_001243194
          Length = 1214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VLNSMLDQS 9
            +LN+M D S
Sbjct: 1065 ILNTMFDTS 1073
>XP_005261155
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMLDQS 9
           NS+LDQ+
Sbjct: 177 NSLLDQA 183
>XP_006723963
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMLDQS 9
           NS+LDQ+
Sbjct: 177 NSLLDQA 183
>XP_006723962
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMLDQS 9
           NS+LDQ+
Sbjct: 177 NSLLDQA 183
>XP_006723081
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LNSMLDQ 8
          +NSML+Q
Sbjct: 75 INSMLEQ 81
>XP_005256615
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VLNSMLDQS 9
            +LN+M D S
Sbjct: 1119 ILNTMFDTS 1127
>XP_005256613
          Length = 1295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VLNSMLDQS 9
            +LN+M D S
Sbjct: 1119 ILNTMFDTS 1127
>XP_005256612
          Length = 1296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VLNSMLDQS 9
            +LN+M D S
Sbjct: 1120 ILNTMFDTS 1128
>XP_005264717
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 499 VLNTMMD 505
>XP_005264716
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 499 VLNTMMD 505
>XP_005264715
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 499 VLNTMMD 505
>XP_005264714
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 588 VLNTMMD 594
>XP_005264712
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 588 VLNTMMD 594
>XP_005264711
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 588 VLNTMMD 594
>XP_006712215
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 588 VLNTMMD 594
>XP_006712214
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 588 VLNTMMD 594
>XP_005264710
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLNSMLD 7
           VLN+M+D
Sbjct: 588 VLNTMMD 594
>XP_006710171
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMLDQS 9
           NS+LDQ+
Sbjct: 177 NSLLDQA 183
>XP_006710170
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMLDQS 9
           NS+LDQ+
Sbjct: 177 NSLLDQA 183
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.121    0.287 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 414,131
Number of extensions: 757
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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