Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001010893                                                           17    4312
NP_689742                                                              16    5631
NP_001028217                                                           16    5631
NP_001253979                                                           16    5631
NP_001253980                                                           16    5631
NP_839955                                                              16    5631
NP_001020095                                                           16    5631
XP_005265807                                                           16    5631
XP_006714105                                                           16    5631
XP_005265805                                                           16    5631
XP_005265804                                                           16    5631
XP_006712406                                                           16    5631
NP_060731                                                              16    5631
NP_001014308                                                           16    7355
NP_001265410                                                           16    7355
NP_001265411                                                           16    7355
NP_001265409                                                           16    7355
NP_060039                                                              16    7355
XP_005258568                                                           16    7355
XP_005266524                                                           16    7355
XP_005266523                                                           16    7355
XP_005266522                                                           16    7355
XP_005266521                                                           16    7355
XP_005266519                                                           16    7355
XP_005266518                                                           16    7355
XP_005266517                                                           16    7355
XP_005266515                                                           16    7355
XP_005266514                                                           16    7355
XP_005266512                                                           16    7355
XP_005266513                                                           16    7355
XP_005266511                                                           16    7355
XP_005266510                                                           16    7355
XP_005266509                                                           16    7355
XP_005266508                                                           16    7355
XP_005266507                                                           16    7355
XP_005266506                                                           16    7355
XP_005266505                                                           16    7355
XP_005266504                                                           16    7355
NP_789781                                                              16    7355
NP_000042                                                              15    9605
NP_001265616                                                           15    9605
NP_001042                                                              15    9605
NP_001273205                                                           15    9605
NP_003595                                                              15    9605
NP_612353                                                              15    9605
NP_001129243                                                           15    9605
NP_001194003                                                           15    9605
NP_001194001                                                           15    9605
NP_001273203                                                           15    9605
NP_065982                                                              15    9605
NP_002556                                                              15    9605
NP_001273204                                                           15    9605
NP_002942                                                              15    9605
NP_001194002                                                           15    9605
XP_005262277                                                           15    9605
XP_006724776                                                           15    9605
XP_005261778                                                           15    9605
XP_006724374                                                           15    9605
XP_006723915                                                           15    9605
XP_006723914                                                           15    9605
XP_005260548                                                           15    9605
XP_006723913                                                           15    9605
XP_006723912                                                           15    9605
XP_005271621                                                           15    9605
XP_006718907                                                           15    9605
XP_006718906                                                           15    9605
XP_005271619                                                           15    9605
XP_005271618                                                           15    9605
NP_001194000                                                           15    9605
>NP_001010893
          Length = 438

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LNFVNVEK 9
          L+F+N+EK
Sbjct: 24 LSFLNIEK 31
>NP_689742
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VLNFVNVE 8
          VLNF NV+
Sbjct: 92 VLNFSNVD 99
>NP_001028217
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VLNFVNVE 8
          VLNF NV+
Sbjct: 92 VLNFSNVD 99
>NP_001253979
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VLNFVNVE 8
          VLNF NV+
Sbjct: 92 VLNFSNVD 99
>NP_001253980
          Length = 842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VLNFVNVE 8
          VLNF NV+
Sbjct: 92 VLNFSNVD 99
>NP_839955
          Length = 879

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVNVEK 9
           FVNVEK
Sbjct: 695 FVNVEK 700
>NP_001020095
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVNVEK 9
           FVNVEK
Sbjct: 710 FVNVEK 715
>XP_005265807
          Length = 879

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVNVEK 9
           FVNVEK
Sbjct: 695 FVNVEK 700
>XP_006714105
          Length = 897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVNVEK 9
           FVNVEK
Sbjct: 713 FVNVEK 718
>XP_005265805
          Length = 912

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVNVEK 9
           FVNVEK
Sbjct: 728 FVNVEK 733
>XP_005265804
          Length = 912

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVNVEK 9
           FVNVEK
Sbjct: 728 FVNVEK 733
>XP_006712406
          Length = 785

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VLNFVNVE 8
          VLNF NV+
Sbjct: 92 VLNFSNVD 99
>NP_060731
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVNVEK 9
           FVNVEK
Sbjct: 710 FVNVEK 715
>NP_001014308
          Length = 779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 544 LNFINV 549
>NP_001265410
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 545 LNFINV 550
>NP_001265411
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 545 LNFINV 550
>NP_001265409
          Length = 811

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 623 LNFINV 628
>NP_060039
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 545 LNFINV 550
>XP_005258568
          Length = 1029

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LNFVNVEK 9
           LNF+NV K
Sbjct: 664 LNFMNVWK 671
>XP_005266524
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 545 LNFINV 550
>XP_005266523
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 544 LNFINV 549
>XP_005266522
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 544 LNFINV 549
>XP_005266521
          Length = 768

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 545 LNFINV 550
>XP_005266519
          Length = 780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 545 LNFINV 550
>XP_005266518
          Length = 800

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 624 LNFINV 629
>XP_005266517
          Length = 812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 624 LNFINV 629
>XP_005266515
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 611 LNFINV 616
>XP_005266514
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 611 LNFINV 616
>XP_005266512
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 624 LNFINV 629
>XP_005266513
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 612 LNFINV 617
>XP_005266511
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 612 LNFINV 617
>XP_005266510
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 623 LNFINV 628
>XP_005266509
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 623 LNFINV 628
>XP_005266508
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 623 LNFINV 628
>XP_005266507
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 624 LNFINV 629
>XP_005266506
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 624 LNFINV 629
>XP_005266505
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 624 LNFINV 629
>XP_005266504
          Length = 859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LNFVNV 7
           LNF+NV
Sbjct: 624 LNFINV 629
>NP_789781
          Length = 1048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LNFVNVEK 9
           LNF+NV K
Sbjct: 664 LNFMNVWK 671
>NP_000042
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    VLNFVNVE 8
            +LN+ N+E
Sbjct: 1238 LLNYTNIE 1245
>NP_001265616
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VLNFVNV 7
           VLN VNV
Sbjct: 275 VLNIVNV 281
>NP_001042
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VLNFVNV 7
           VLN VNV
Sbjct: 275 VLNIVNV 281
>NP_001273205
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LNFVNVEK 9
          L+F+NV+K
Sbjct: 9  LHFLNVKK 16
>NP_003595
          Length = 1257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NFVNVE 8
           N+VNVE
Sbjct: 958 NYVNVE 963
>NP_612353
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VLNFVNV 7
          +LNFVN+
Sbjct: 72 LLNFVNL 78
>NP_001129243
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LNFVNVE 8
           LNF+NV+
Sbjct: 302 LNFMNVK 308
>NP_001194003
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VLNFVNV 7
          +LNFVN+
Sbjct: 10 LLNFVNL 16
>NP_001194001
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VLNFVNV 7
          +LNFVN+
Sbjct: 10 LLNFVNL 16
>NP_001273203
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LNFVNVEK 9
          L+F+NV+K
Sbjct: 49 LHFLNVKK 56
>NP_065982
          Length = 787

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LNFVNVEK 9
          L+F+NV+K
Sbjct: 76 LHFLNVKK 83
>NP_002556
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VLNFVNV 7
           VLN VNV
Sbjct: 280 VLNIVNV 286
>NP_001273204
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LNFVNVEK 9
          L+F+NV+K
Sbjct: 9  LHFLNVKK 16
>NP_002942
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LNFVNVE 8
           LNF+NV+
Sbjct: 334 LNFMNVK 340
>NP_001194002
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VLNFVNV 7
          +LNFVN+
Sbjct: 10 LLNFVNL 16
>XP_005262277
          Length = 1256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NFVNVE 8
           N+VNVE
Sbjct: 958 NYVNVE 963
>XP_006724776
          Length = 1256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NFVNVE 8
           N+VNVE
Sbjct: 958 NYVNVE 963
>XP_005261778
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VLNFVNV 7
           VLN VNV
Sbjct: 275 VLNIVNV 281
>XP_006724374
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VLNFVNV 7
           VLN VNV
Sbjct: 275 VLNIVNV 281
>XP_006723915
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LNFVNVE 8
           LNF+NV+
Sbjct: 350 LNFMNVK 356
>XP_006723914
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LNFVNVE 8
           LNF+NV+
Sbjct: 350 LNFMNVK 356
>XP_005260548
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LNFVNVE 8
           LNF+NV+
Sbjct: 334 LNFMNVK 340
>XP_006723913
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LNFVNVE 8
           LNF+NV+
Sbjct: 350 LNFMNVK 356
>XP_006723912
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LNFVNVE 8
           LNF+NV+
Sbjct: 350 LNFMNVK 356
>XP_005271621
          Length = 2708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VLNFVNVE 8
           +LN+ N+E
Sbjct: 890 LLNYTNIE 897
>XP_006718907
          Length = 3050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    VLNFVNVE 8
            +LN+ N+E
Sbjct: 1232 LLNYTNIE 1239
>XP_006718906
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    VLNFVNVE 8
            +LN+ N+E
Sbjct: 1238 LLNYTNIE 1245
>XP_005271619
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    VLNFVNVE 8
            +LN+ N+E
Sbjct: 1238 LLNYTNIE 1245
>XP_005271618
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    VLNFVNVE 8
            +LN+ N+E
Sbjct: 1238 LLNYTNIE 1245
>NP_001194000
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VLNFVNV 7
          +LNFVN+
Sbjct: 10 LLNFVNL 16
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.140    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 409,831
Number of extensions: 723
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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