Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004382                                                              18    1482
NP_001191387                                                           16    5631
NP_683760                                                              16    5631
NP_061117                                                              16    5631
NP_001020368                                                           16    5631
XP_005266503                                                           16    5631
XP_005266502                                                           16    5631
NP_003991                                                              16    5631
NP_001020370                                                           16    5631
NP_001001665                                                           16    7355
NP_037440                                                              16    7355
XP_005247460                                                           16    7355
XP_005247459                                                           16    7355
XP_006712546                                                           16    7355
NP_000008                                                              15    9605
NP_000675                                                              15    9605
NP_733828                                                              15    9605
NP_001138571                                                           15    9605
NP_001265713                                                           15    9605
NP_001430                                                              15    9605
NP_001248370                                                           15    9605
NP_001248371                                                           15    9605
NP_001248369                                                           15    9605
NP_001028197                                                           15    9605
NP_001258867                                                           15    9605
NP_057258                                                              15    9605
NP_057133                                                              15    9605
NP_001273689                                                           15    9605
NP_005818                                                              15    9605
NP_115524                                                              15    9605
NP_001401                                                              15    9605
NP_061917                                                              15    9605
NP_851782                                                              15    9605
NP_001107592                                                           15    9605
NP_001001671                                                           15    9605
XP_005256986                                                           15    9605
XP_006721695                                                           15    9605
XP_005267778                                                           15    9605
XP_005269237                                                           15    9605
XP_005269236                                                           15    9605
XP_005269235                                                           15    9605
XP_006719693                                                           15    9605
XP_005269233                                                           15    9605
XP_006719000                                                           15    9605
XP_005252094                                                           15    9605
XP_006717200                                                           15    9605
XP_005252092                                                           15    9605
XP_005262782                                                           15    9605
XP_006714141                                                           15    9605
XP_005262780                                                           15    9605
XP_005262779                                                           15    9605
XP_006712663                                                           15    9605
XP_006712662                                                           15    9605
XP_006712661                                                           15    9605
XP_006712660                                                           15    9605
XP_005270679                                                           15    9605
XP_005270678                                                           15    9605
NP_612351                                                              15    9605
>NP_004382
          Length = 501

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  VLLVIAGYL 9
          +L+VIAGYL
Sbjct: 11 LLVVIAGYL 19
>NP_001191387
          Length = 417

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LLVIAGYL 9
          LLV+ GYL
Sbjct: 16 LLVLLGYL 23
>NP_683760
          Length = 417

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LLVIAGYL 9
          LLV+ GYL
Sbjct: 16 LLVLLGYL 23
>NP_061117
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LLVIAGYL 9
          LLV+ GYL
Sbjct: 16 LLVLLGYL 23
>NP_001020368
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VLLVIAGYL 9
          +LL I GYL
Sbjct: 87 ILLSIGGYL 95
>XP_005266503
          Length = 328

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LLVIAGYL 9
          LLV+ GYL
Sbjct: 16 LLVLLGYL 23
>XP_005266502
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LLVIAGYL 9
          LLV+ GYL
Sbjct: 16 LLVLLGYL 23
>NP_003991
          Length = 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VLLVIAGYL 9
           +LL I GYL
Sbjct: 97  ILLSIGGYL 105
>NP_001020370
          Length = 311

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VLLVIAGYL 9
          +LL I GYL
Sbjct: 18 ILLSIGGYL 26
>NP_001001665
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LVIAGYL 9
           LVI GYL
Sbjct: 256 LVIGGYL 262
>NP_037440
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLLVIAGYL 9
           +LLV  GY+
Sbjct: 225 ILLVTTGYI 233
>XP_005247460
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLLVIAGYL 9
           +LLV  GY+
Sbjct: 225 ILLVTTGYI 233
>XP_005247459
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLLVIAGYL 9
           +LLV  GY+
Sbjct: 225 ILLVTTGYI 233
>XP_006712546
          Length = 447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LVIAGYL 9
           LVI GYL
Sbjct: 331 LVIGGYL 337
>NP_000008
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LVIAGYL 9
           LVIAG+L
Sbjct: 400 LVIAGHL 406
>NP_000675
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VLLVIAG 7
          VLL++AG
Sbjct: 69 VLLIVAG 75
>NP_733828
          Length = 1322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LLVIAGYL 9
            LL++ GY+
Sbjct: 1160 LLILCGYI 1167
>NP_001138571
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLLVIAGY 8
           VLL ++GY
Sbjct: 340 VLLFVSGY 347
>NP_001265713
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VLLVIAG 7
          VLL++AG
Sbjct: 77 VLLIVAG 83
>NP_001430
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VLLVIAGYL 9
          VLL++AG L
Sbjct: 28 VLLLVAGAL 36
>NP_001248370
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VLLVIAGYL 9
          VLL++AG L
Sbjct: 36 VLLLVAGAL 44
>NP_001248371
          Length = 147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VLLVIAGYL 9
          VLL++AG L
Sbjct: 28 VLLLVAGAL 36
>NP_001248369
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VLLVIAGYL 9
          VLL++AG L
Sbjct: 28 VLLLVAGAL 36
>NP_001028197
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VLLVIAGYL 9
          VLL++AG L
Sbjct: 28 VLLLVAGAL 36
>NP_001258867
          Length = 2845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VLLVIAGY 8
           VLLV  GY
Sbjct: 525 VLLVAGGY 532
>NP_057258
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LVIAGY 8
           LV+AGY
Sbjct: 465 LVVAGY 470
>NP_057133
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LVIAGY 8
          LV+AGY
Sbjct: 76 LVVAGY 81
>NP_001273689
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LVIAGY 8
           LV+AGY
Sbjct: 387 LVVAGY 392
>NP_005818
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLLVIAG 7
           VLL++AG
Sbjct: 181 VLLIVAG 187
>NP_115524
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLLVIAGYL 9
           +LLVI G+L
Sbjct: 473 LLLVIPGHL 481
>NP_001401
          Length = 2778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VLLVIAGY 8
           VLLV  GY
Sbjct: 525 VLLVAGGY 532
>NP_061917
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  LLVIAGY 8
          LLV AGY
Sbjct: 33 LLVAAGY 39
>NP_851782
          Length = 1283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LLVIAGYL 9
            LL++ GY+
Sbjct: 1121 LLILCGYI 1128
>NP_001107592
          Length = 811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LLVIAGYL 9
           +LV+ GY+
Sbjct: 302 ILVVCGYI 309
>NP_001001671
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLLVIAG 7
           VLL++AG
Sbjct: 408 VLLIVAG 414
>XP_005256986
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VLLVIAG 7
          VLL++AG
Sbjct: 77 VLLIVAG 83
>XP_006721695
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLLVIAG 7
           VLL++AG
Sbjct: 215 VLLIVAG 221
>XP_005267778
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LVIAGY 8
          LV+AGY
Sbjct: 76 LVVAGY 81
>XP_005269237
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLLVIAGYL 9
           +LLVI G+L
Sbjct: 473 LLLVIPGHL 481
>XP_005269236
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLLVIAGYL 9
           +LLVI G+L
Sbjct: 473 LLLVIPGHL 481
>XP_005269235
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLLVIAGYL 9
           +LLVI G+L
Sbjct: 473 LLLVIPGHL 481
>XP_006719693
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLLVIAGYL 9
           +LLVI G+L
Sbjct: 473 LLLVIPGHL 481
>XP_005269233
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLLVIAGYL 9
           +LLVI G+L
Sbjct: 473 LLLVIPGHL 481
>XP_006719000
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VLLVIAGYL 9
          +LLV+ G+L
Sbjct: 17 LLLVVLGFL 25
>XP_005252094
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LVIAGY 8
           LV+AGY
Sbjct: 387 LVVAGY 392
>XP_006717200
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LVIAGY 8
           LV+AGY
Sbjct: 387 LVVAGY 392
>XP_005252092
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LVIAGY 8
           LV+AGY
Sbjct: 465 LVVAGY 470
>XP_005262782
          Length = 1216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LLVIAGYL 9
            LL++ GY+
Sbjct: 1054 LLILCGYI 1061
>XP_006714141
          Length = 1259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LLVIAGYL 9
            LL++ GY+
Sbjct: 1097 LLILCGYI 1104
>XP_005262780
          Length = 1307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LLVIAGYL 9
            LL++ GY+
Sbjct: 1145 LLILCGYI 1152
>XP_005262779
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LLVIAGYL 9
            LL++ GY+
Sbjct: 1152 LLILCGYI 1159
>XP_006712663
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  LLVIAGY 8
          LLV AGY
Sbjct: 89 LLVAAGY 95
>XP_006712662
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  LLVIAGY 8
          LLV AGY
Sbjct: 89 LLVAAGY 95
>XP_006712661
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  LLVIAGY 8
          LLV AGY
Sbjct: 89 LLVAAGY 95
>XP_006712660
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  LLVIAGY 8
          LLV AGY
Sbjct: 89 LLVAAGY 95
>XP_005270679
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VLLVIAGYL 9
          VLL++AG L
Sbjct: 28 VLLLVAGAL 36
>XP_005270678
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VLLVIAGYL 9
          VLL++AG L
Sbjct: 28 VLLLVAGAL 36
>NP_612351
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VLLVIAGYL 9
          +LLV+ G+L
Sbjct: 17 LLLVVLGFL 25
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.164    0.446 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 402,572
Number of extensions: 508
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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