Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1935
NP_001035957                                                           18    1935
XP_006721990                                                           18    1935
XP_006721989                                                           18    1935
XP_005258041                                                           18    1935
XP_006721988                                                           18    1935
XP_006721987                                                           18    1935
XP_006721986                                                           18    1935
XP_005258040                                                           18    1935
XP_006721985                                                           18    1935
NP_000095                                                              17    4312
NP_009220                                                              16    5631
NP_000893                                                              16    5631
NP_009218                                                              16    5631
NP_009219                                                              16    5631
NP_005344                                                              16    5631
XP_006717968                                                           16    5631
XP_006717967                                                           16    5631
XP_006717966                                                           16    5631
XP_006717965                                                           16    5631
XP_006713710                                                           16    5631
XP_006713709                                                           16    5631
NP_001601                                                              16    7355
XP_005253041                                                           16    7355
NP_055513                                                              15    9605
XP_006711904                                                           15    9605
NP_001004297                                                           15    9605
>NP_000258
          Length = 2818

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLLTVLAT 9
            LLLTVLAT
Sbjct: 2597 LLLTVLAT 2604
>NP_001035957
          Length = 2839

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLLTVLAT 9
            LLLTVLAT
Sbjct: 2618 LLLTVLAT 2625
>XP_006721990
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLLTVLAT 9
            LLLTVLAT
Sbjct: 2628 LLLTVLAT 2635
>XP_006721989
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLLTVLAT 9
            LLLTVLAT
Sbjct: 2628 LLLTVLAT 2635
>XP_005258041
          Length = 2836

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLLTVLAT 9
            LLLTVLAT
Sbjct: 2597 LLLTVLAT 2604
>XP_006721988
          Length = 2846

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLLTVLAT 9
            LLLTVLAT
Sbjct: 2607 LLLTVLAT 2614
>XP_006721987
          Length = 2849

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLLTVLAT 9
            LLLTVLAT
Sbjct: 2628 LLLTVLAT 2635
>XP_006721986
          Length = 2854

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLLTVLAT 9
            LLLTVLAT
Sbjct: 2615 LLLTVLAT 2622
>XP_005258040
          Length = 2857

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLLTVLAT 9
            LLLTVLAT
Sbjct: 2618 LLLTVLAT 2625
>XP_006721985
          Length = 2867

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LLLTVLAT 9
            LLLTVLAT
Sbjct: 2628 LLLTVLAT 2635
>NP_000095
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  VLLLTVLAT 9
          +LLL+VLAT
Sbjct: 24 LLLLSVLAT 32
>NP_009220
          Length = 750

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  VLLLTVLA 8
          VLLLT++A
Sbjct: 35 VLLLTIIA 42
>NP_000893
          Length = 750

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  VLLLTVLA 8
          VLLLT++A
Sbjct: 35 VLLLTIIA 42
>NP_009218
          Length = 750

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  VLLLTVLA 8
          VLLLT++A
Sbjct: 35 VLLLTIIA 42
>NP_009219
          Length = 750

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  VLLLTVLA 8
          VLLLT++A
Sbjct: 35 VLLLTIIA 42
>NP_005344
          Length = 1161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  VLLLTVLAT 9
          VLLL+VLA+
Sbjct: 6  VLLLSVLAS 14
>XP_006717968
          Length = 952

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VLLLTVLA 8
           ++LLTVLA
Sbjct: 504 IILLTVLA 511
>XP_006717967
          Length = 952

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VLLLTVLA 8
           ++LLTVLA
Sbjct: 504 IILLTVLA 511
>XP_006717966
          Length = 952

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VLLLTVLA 8
           ++LLTVLA
Sbjct: 504 IILLTVLA 511
>XP_006717965
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VLLLTVLA 8
           ++LLTVLA
Sbjct: 510 IILLTVLA 517
>XP_006713710
          Length = 750

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  VLLLTVLA 8
          VLLLT++A
Sbjct: 35 VLLLTIIA 42
>XP_006713709
          Length = 750

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  VLLLTVLA 8
          VLLLT++A
Sbjct: 35 VLLLTIIA 42
>NP_001601
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VLLLTVL 7
           VLLLTVL
Sbjct: 397 VLLLTVL 403
>XP_005253041
          Length = 236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VLLLTVL 7
           VLLLTVL
Sbjct: 210 VLLLTVL 216
>NP_055513
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VLLLTVL 7
           VLLLT+L
Sbjct: 703 VLLLTIL 709
>XP_006711904
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VLLLTVL 7
           VLLLT+L
Sbjct: 526 VLLLTIL 532
>NP_001004297
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VLLLTVLA 8
           +LLLTV+A
Sbjct: 130 LLLLTVMA 137
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.146    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 290,462
Number of extensions: 477
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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