Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              18    1135
NP_005913                                                              18    1135
XP_005267046                                                           18    1135
XP_005267045                                                           18    1135
NP_001138384                                                           16    5631
NP_001129503                                                           16    5631
NP_006386                                                              16    5631
NP_066000                                                              16    5631
NP_001004751                                                           16    5631
NP_001017924                                                           16    5631
NP_001271152                                                           16    5631
XP_006713781                                                           16    5631
XP_006712999                                                           16    5631
XP_005264860                                                           16    5631
XP_006712998                                                           16    5631
XP_006712997                                                           16    5631
XP_006712996                                                           16    5631
XP_006712995                                                           16    5631
XP_006712994                                                           16    5631
NP_001004752                                                           16    5631
NP_001008539                                                           16    7355
NP_001158243                                                           16    7355
NP_003037                                                              16    7355
NP_001275677                                                           16    7355
NP_878907                                                              16    7355
NP_001277026                                                           16    7355
NP_001139808                                                           16    7355
XP_005273981                                                           16    7355
XP_005273669                                                           16    7355
XP_005273668                                                           16    7355
XP_005273667                                                           16    7355
XP_006716452                                                           16    7355
XP_005273666                                                           16    7355
NP_079203                                                              15    9605
XP_006722159                                                           15    9605
XP_006713491                                                           15    9605
>NP_006715
          Length = 1558

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VLINAYLLL 9
           VLI+AYLLL
Sbjct: 895 VLIDAYLLL 903
>NP_005913
          Length = 1608

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VLINAYLLL 9
           VLI+AYLLL
Sbjct: 895 VLIDAYLLL 903
>XP_005267046
          Length = 1554

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VLINAYLLL 9
           VLI+AYLLL
Sbjct: 895 VLIDAYLLL 903
>XP_005267045
          Length = 1604

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VLINAYLLL 9
           VLI+AYLLL
Sbjct: 895 VLIDAYLLL 903
>NP_001138384
          Length = 623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           VL+N +LLL
Sbjct: 126 VLLNKFLLL 134
>NP_001129503
          Length = 676

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           VL+N +LLL
Sbjct: 126 VLLNKFLLL 134
>NP_006386
          Length = 703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           VL+N +LLL
Sbjct: 126 VLLNKFLLL 134
>NP_066000
          Length = 771

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           +L+N YL+L
Sbjct: 640 MLVNIYLML 648
>NP_001004751
          Length = 324

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VLINAYLLL 9
           V+ N YLLL
Sbjct: 287 VMANTYLLL 295
>NP_001017924
          Length = 550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   VLINAYLL 8
           +L+N+YL+
Sbjct: 223 ILVNSYLI 230
>NP_001271152
          Length = 560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   VLINAYLL 8
           +L+N+YL+
Sbjct: 223 ILVNSYLI 230
>XP_006713781
          Length = 771

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           +L+N YL+L
Sbjct: 640 MLVNIYLML 648
>XP_006712999
          Length = 685

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           VL+N +LLL
Sbjct: 126 VLLNKFLLL 134
>XP_005264860
          Length = 695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           VL+N +LLL
Sbjct: 126 VLLNKFLLL 134
>XP_006712998
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           VL+N +LLL
Sbjct: 126 VLLNKFLLL 134
>XP_006712997
          Length = 701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           VL+N +LLL
Sbjct: 126 VLLNKFLLL 134
>XP_006712996
          Length = 738

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           VL+N +LLL
Sbjct: 126 VLLNKFLLL 134
>XP_006712995
          Length = 738

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           VL+N +LLL
Sbjct: 126 VLLNKFLLL 134
>XP_006712994
          Length = 738

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           VL+N +LLL
Sbjct: 126 VLLNKFLLL 134
>NP_001004752
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VLINAYLLL 9
           V+ N YLLL
Sbjct: 277 VMANVYLLL 285
>NP_001008539
          Length = 658

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           +L+N YL++
Sbjct: 569 ILVNIYLMV 577
>NP_001158243
          Length = 698

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           +L+N YL++
Sbjct: 609 ILVNIYLMV 617
>NP_003037
          Length = 697

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           +L+N YL++
Sbjct: 608 ILVNIYLMV 616
>NP_001275677
          Length = 604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NAYLLL 9
           NAYLLL
Sbjct: 329 NAYLLL 334
>NP_878907
          Length = 544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NAYLLL 9
           NAYLLL
Sbjct: 329 NAYLLL 334
>NP_001277026
          Length = 142

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LINAYLLL 9
          L+ AYLLL
Sbjct: 48 LLQAYLLL 55
>NP_001139808
          Length = 223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LINAYLLL 9
           L+ AYLLL
Sbjct: 129 LLQAYLLL 136
>XP_005273981
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NAYLLL 9
           NAYLLL
Sbjct: 329 NAYLLL 334
>XP_005273669
          Length = 658

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           +L+N YL++
Sbjct: 569 ILVNIYLMV 577
>XP_005273668
          Length = 658

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           +L+N YL++
Sbjct: 569 ILVNIYLMV 577
>XP_005273667
          Length = 658

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           +L+N YL++
Sbjct: 569 ILVNIYLMV 577
>XP_006716452
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           +L+N YL++
Sbjct: 587 ILVNIYLMV 595
>XP_005273666
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLINAYLLL 9
           +L+N YL++
Sbjct: 588 ILVNIYLMV 596
>NP_079203
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LINAYL 7
           L+NAYL
Sbjct: 742 LVNAYL 747
>XP_006722159
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LINAYL 7
           L+NAYL
Sbjct: 739 LVNAYL 744
>XP_006713491
          Length = 1425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  VLINAYLL 8
          +L+NAY++
Sbjct: 5  LLVNAYVM 12
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.160    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 398,548
Number of extensions: 555
Number of successful extensions: 36
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 36
Number of HSP's successfully gapped: 36
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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