Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001137469                                                           18    1482
NP_001137468                                                           18    1482
NP_060715                                                              18    1482
NP_001158508                                                           18    1935
NP_002532                                                              18    1935
XP_005249816                                                           18    1935
XP_005249818                                                           18    1935
NP_001193731                                                           17    3301
NP_004872                                                              17    3301
NP_671713                                                              17    3301
NP_055511                                                              17    3301
XP_005277723                                                           17    3301
XP_005270386                                                           17    3301
XP_005264707                                                           17    3301
XP_006712213                                                           17    3301
NP_009117                                                              17    4312
XP_005260321                                                           17    4312
XP_005260320                                                           17    4312
XP_006723758                                                           17    4312
XP_006723757                                                           17    4312
XP_006723756                                                           17    4312
XP_006723755                                                           17    4312
XP_006723754                                                           17    4312
XP_006723753                                                           17    4312
XP_005260319                                                           17    4312
NP_036536                                                              17    4312
NP_001167448                                                           16    5631
NP_060110                                                              16    5631
XP_006715203                                                           16    5631
XP_006715202                                                           16    5631
XP_006715201                                                           16    5631
XP_006715200                                                           16    5631
XP_005249275                                                           16    5631
XP_006715199                                                           16    5631
NP_056344                                                              16    7355
NP_036345                                                              16    7355
XP_006715519                                                           16    7355
NP_001268232                                                           15    9605
NP_006406                                                              15    9605
NP_001034254                                                           15    9605
NP_055919                                                              15    9605
NP_001018098                                                           15    9605
NP_060154                                                              15    9605
NP_060550                                                              15    9605
NP_065872                                                              15    9605
NP_003881                                                              15    9605
NP_705618                                                              15    9605
NP_612369                                                              15    9605
NP_004289                                                              15    9605
NP_002034                                                              15    9605
NP_001265241                                                           15    9605
XP_005273907                                                           15    9605
XP_005273906                                                           15    9605
>NP_001137469
          Length = 801

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   IHVRLSG 9
           IHVRLSG
Sbjct: 447 IHVRLSG 453
>NP_001137468
          Length = 953

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   IHVRLSG 9
           IHVRLSG
Sbjct: 599 IHVRLSG 605
>NP_060715
          Length = 1010

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   IHVRLSG 9
           IHVRLSG
Sbjct: 656 IHVRLSG 662
>NP_001158508
          Length = 1019

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IHVRLSG 9
           IH+RLSG
Sbjct: 665 IHIRLSG 671
>NP_002532
          Length = 1023

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IHVRLSG 9
           IH+RLSG
Sbjct: 669 IHIRLSG 675
>XP_005249816
          Length = 1038

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IHVRLSG 9
           IH+RLSG
Sbjct: 684 IHIRLSG 690
>XP_005249818
          Length = 1034

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IHVRLSG 9
           IH+RLSG
Sbjct: 680 IHIRLSG 686
>NP_001193731
          Length = 248

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VLIHVRLSG 9
           VLIH  LSG
Sbjct: 144 VLIHAGLSG 152
>NP_004872
          Length = 332

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VLIHVRLSG 9
           VLIH  LSG
Sbjct: 144 VLIHAGLSG 152
>NP_671713
          Length = 332

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VLIHVRLSG 9
           VLIH  LSG
Sbjct: 144 VLIHAGLSG 152
>NP_055511
          Length = 458

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VLIHVRLSG 9
           V IH RLSG
Sbjct: 276 VKIHCRLSG 284
>XP_005277723
          Length = 458

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VLIHVRLSG 9
           V IH RLSG
Sbjct: 276 VKIHCRLSG 284
>XP_005270386
          Length = 482

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VLIHVRLSG 9
           V IH RLSG
Sbjct: 300 VKIHCRLSG 308
>XP_005264707
          Length = 243

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  VLIHVRLSG 9
          VLIH  LSG
Sbjct: 55 VLIHAGLSG 63
>XP_006712213
          Length = 248

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VLIHVRLSG 9
           VLIH  LSG
Sbjct: 144 VLIHAGLSG 152
>NP_009117
          Length = 2442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRLSG
Sbjct: 209 HVRLSG 214
>XP_005260321
          Length = 2365

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRLSG
Sbjct: 209 HVRLSG 214
>XP_005260320
          Length = 2370

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRLSG
Sbjct: 209 HVRLSG 214
>XP_006723758
          Length = 2386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRLSG
Sbjct: 209 HVRLSG 214
>XP_006723757
          Length = 2404

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRLSG
Sbjct: 209 HVRLSG 214
>XP_006723756
          Length = 2442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRLSG
Sbjct: 209 HVRLSG 214
>XP_006723755
          Length = 2442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRLSG
Sbjct: 209 HVRLSG 214
>XP_006723754
          Length = 2442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRLSG
Sbjct: 209 HVRLSG 214
>XP_006723753
          Length = 2442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRLSG
Sbjct: 209 HVRLSG 214
>XP_005260319
          Length = 2442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRLSG
Sbjct: 209 HVRLSG 214
>NP_036536
          Length = 131

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LIHVRLSG 9
          LIH+ LSG
Sbjct: 90 LIHLNLSG 97
>NP_001167448
          Length = 1365

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 426 LMHINLSG 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 339 LVHLDLSG 346
>NP_060110
          Length = 1371

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 426 LMHINLSG 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 339 LVHLDLSG 346
>XP_006715203
          Length = 949

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 426 LMHINLSG 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 339 LVHLDLSG 346
>XP_006715202
          Length = 966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 426 LMHINLSG 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 339 LVHLDLSG 346
>XP_006715201
          Length = 1375

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 426 LMHINLSG 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 339 LVHLDLSG 346
>XP_006715200
          Length = 1419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 426 LMHINLSG 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 339 LVHLDLSG 346
>XP_005249275
          Length = 1421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 426 LMHINLSG 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 339 LVHLDLSG 346
>XP_006715199
          Length = 1425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 426 LMHINLSG 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 339 LVHLDLSG 346
>NP_056344
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLIHVRLSG 9
           VL+H  L+G
Sbjct: 386 VLLHAHLAG 394
>NP_036345
          Length = 493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLIHVRLSG 9
           V++HV L+G
Sbjct: 251 VVLHVALTG 259
>XP_006715519
          Length = 603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLIHVRLSG 9
           VL+H  L+G
Sbjct: 376 VLLHAHLAG 384
>NP_001268232
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VLIHVRLSG 9
           V+ H RLSG
Sbjct: 324 VIDHQRLSG 332
>NP_006406
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VLIHVRLSG 9
           V+ H RLSG
Sbjct: 324 VIDHQRLSG 332
>NP_001034254
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLIHVRLSG 9
           +L+H+ LSG
Sbjct: 152 LLLHLLLSG 160
>NP_055919
          Length = 1938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRL+G
Sbjct: 487 HVRLTG 492
>NP_001018098
          Length = 3628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LIHVRLS 8
           L+HVR+S
Sbjct: 812 LMHVRIS 818
>NP_060154
          Length = 3710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LIHVRLS 8
           L+HVR+S
Sbjct: 769 LMHVRIS 775
>NP_060550
          Length = 3585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LIHVRLS 8
           L+HVR+S
Sbjct: 769 LMHVRIS 775
>NP_065872
          Length = 3753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LIHVRLS 8
           L+HVR+S
Sbjct: 812 LMHVRIS 818
>NP_003881
          Length = 5405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    LIHVRLSG 9
            L+H  LSG
Sbjct: 2167 LLHAHLSG 2174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    LIHVRLSG 9
            L+H  LSG
Sbjct: 3368 LLHAHLSG 3375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    LIHVRLSG 9
            L+H  LSG
Sbjct: 4569 LLHAHLSG 4576
>NP_705618
          Length = 1391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LIHVRL 7
           L+HVRL
Sbjct: 387 LVHVRL 392
>NP_612369
          Length = 1372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIHVRLSG 9
           L+H+ LSG
Sbjct: 366 LVHLDLSG 373
>NP_004289
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LIHVRL 7
           L+HVRL
Sbjct: 328 LVHVRL 333
>NP_002034
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLIHVRLSG 9
           +++H+ LSG
Sbjct: 407 IVVHLGLSG 415
>NP_001265241
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LIHVRL 7
           L+HVRL
Sbjct: 387 LVHVRL 392
>XP_005273907
          Length = 1930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRL+G
Sbjct: 487 HVRLTG 492
>XP_005273906
          Length = 1932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   HVRLSG 9
           HVRL+G
Sbjct: 487 HVRLTG 492
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.153    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 520,911
Number of extensions: 859
Number of successful extensions: 63
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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