Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              18    1482
XP_005271621                                                           18    1482
XP_006718907                                                           18    1482
XP_006718906                                                           18    1482
XP_005271619                                                           18    1482
XP_005271618                                                           18    1482
NP_060899                                                              17    4312
NP_909119                                                              17    4312
NP_057537                                                              17    4312
XP_006725524                                                           17    4312
XP_006725523                                                           17    4312
XP_005276828                                                           17    4312
XP_006726279                                                           17    4312
XP_006714722                                                           17    4312
XP_006714721                                                           17    4312
XP_005265280                                                           17    4312
XP_006713268                                                           17    4312
NP_038477                                                              16    7355
XP_005268661                                                           16    7355
XP_005268660                                                           16    7355
XP_005268659                                                           16    7355
XP_005268657                                                           16    7355
XP_006719270                                                           16    7355
XP_005268656                                                           16    7355
XP_005268654                                                           16    7355
XP_005268653                                                           16    7355
NP_066997                                                              15    9605
NP_004658                                                              15    9605
NP_872630                                                              15    9605
NP_003334                                                              15    9605
NP_001189418                                                           15    9605
NP_055640                                                              15    9605
NP_940969                                                              15    9605
NP_061927                                                              15    9605
XP_006720790                                                           15    9605
XP_005268334                                                           15    9605
XP_005268333                                                           15    9605
XP_006720789                                                           15    9605
XP_006717969                                                           15    9605
XP_005269977                                                           15    9605
XP_006717968                                                           15    9605
XP_006717967                                                           15    9605
XP_006717966                                                           15    9605
XP_006717965                                                           15    9605
XP_005265966                                                           15    9605
>NP_000042
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           VLEKIL+SL
Sbjct: 607 VLEKILVSL 615
>XP_005271621
          Length = 2708

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           VLEKIL+SL
Sbjct: 259 VLEKILVSL 267
>XP_006718907
          Length = 3050

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           VLEKIL+SL
Sbjct: 607 VLEKILVSL 615
>XP_006718906
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           VLEKIL+SL
Sbjct: 607 VLEKILVSL 615
>XP_005271619
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           VLEKIL+SL
Sbjct: 607 VLEKILVSL 615
>XP_005271618
          Length = 3056

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           VLEKIL+SL
Sbjct: 607 VLEKILVSL 615
>NP_060899
          Length = 2624

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   VLEKILLS 8
           VLEKIL+S
Sbjct: 833 VLEKILVS 840
>NP_909119
          Length = 715

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           V+E++LLSL
Sbjct: 345 VMEQVLLSL 353
>NP_057537
          Length = 722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           V+E++LLSL
Sbjct: 352 VMEQVLLSL 360
>XP_006725524
          Length = 2584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   VLEKILLS 8
           VLEKIL+S
Sbjct: 833 VLEKILVS 840
>XP_006725523
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   VLEKILLS 8
           VLEKIL+S
Sbjct: 833 VLEKILVS 840
>XP_005276828
          Length = 2584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   VLEKILLS 8
           VLEKIL+S
Sbjct: 833 VLEKILVS 840
>XP_006726279
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   VLEKILLS 8
           VLEKIL+S
Sbjct: 833 VLEKILVS 840
>XP_006714722
          Length = 2584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   VLEKILLS 8
           VLEKIL+S
Sbjct: 833 VLEKILVS 840
>XP_006714721
          Length = 2623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   VLEKILLS 8
           VLEKIL+S
Sbjct: 833 VLEKILVS 840
>XP_005265280
          Length = 644

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           V+E++LLSL
Sbjct: 274 VMEQVLLSL 282
>XP_006713268
          Length = 695

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           V+E++LLSL
Sbjct: 352 VMEQVLLSL 360
>NP_038477
          Length = 1905

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    VLEKILLS 8
            VLEK LLS
Sbjct: 1613 VLEKALLS 1620
>XP_005268661
          Length = 1657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    VLEKILLS 8
            VLEK LLS
Sbjct: 1365 VLEKALLS 1372
>XP_005268660
          Length = 1875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    VLEKILLS 8
            VLEK LLS
Sbjct: 1583 VLEKALLS 1590
>XP_005268659
          Length = 1894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    VLEKILLS 8
            VLEK LLS
Sbjct: 1602 VLEKALLS 1609
>XP_005268657
          Length = 1903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    VLEKILLS 8
            VLEK LLS
Sbjct: 1611 VLEKALLS 1618
>XP_006719270
          Length = 1903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    VLEKILLS 8
            VLEK LLS
Sbjct: 1611 VLEKALLS 1618
>XP_005268656
          Length = 1903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    VLEKILLS 8
            VLEK LLS
Sbjct: 1611 VLEKALLS 1618
>XP_005268654
          Length = 1923

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    VLEKILLS 8
            VLEK LLS
Sbjct: 1632 VLEKALLS 1639
>XP_005268653
          Length = 1924

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    VLEKILLS 8
            VLEK LLS
Sbjct: 1632 VLEKALLS 1639
>NP_066997
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEKILLSL 9
           LE+ILL+L
Sbjct: 725 LERILLTL 732
>NP_004658
          Length = 4834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    LEKILLSL 9
            L KILLSL
Sbjct: 3380 LAKILLSL 3387
>NP_872630
          Length = 137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LEKILLSL 9
          +EKILLS+
Sbjct: 88 VEKILLSV 95
>NP_003334
          Length = 165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEKILLSL 9
           +EKILLS+
Sbjct: 116 VEKILLSV 123
>NP_001189418
          Length = 95

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LEKILLSL 9
          +EKILLS+
Sbjct: 46 VEKILLSV 53
>NP_055640
          Length = 2271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LEKILLSL 9
           LE+ILL+L
Sbjct: 700 LERILLTL 707
>NP_940969
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLEKILLS 8
           +++KILLS
Sbjct: 94  IIQKILLS 101
>NP_061927
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           ++EKILL++
Sbjct: 752 LIEKILLNI 760
>XP_006720790
          Length = 4748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    LEKILLSL 9
            L KILLSL
Sbjct: 3294 LAKILLSL 3301
>XP_005268334
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    LEKILLSL 9
            L KILLSL
Sbjct: 3342 LAKILLSL 3349
>XP_005268333
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    LEKILLSL 9
            L KILLSL
Sbjct: 3342 LAKILLSL 3349
>XP_006720789
          Length = 4829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    LEKILLSL 9
            L KILLSL
Sbjct: 3375 LAKILLSL 3382
>XP_006717969
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           ++EKILL++
Sbjct: 356 LIEKILLNI 364
>XP_005269977
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           ++EKILL++
Sbjct: 472 LIEKILLNI 480
>XP_006717968
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           ++EKILL++
Sbjct: 869 LIEKILLNI 877
>XP_006717967
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           ++EKILL++
Sbjct: 869 LIEKILLNI 877
>XP_006717966
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           ++EKILL++
Sbjct: 869 LIEKILLNI 877
>XP_006717965
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VLEKILLSL 9
           ++EKILL++
Sbjct: 875 LIEKILLNI 883
>XP_005265966
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLEKILLS 8
           +++KILLS
Sbjct: 528 IIQKILLS 535
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.151    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 435,922
Number of extensions: 571
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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