Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              17    2528
NP_005106                                                              17    4312
NP_059447                                                              17    4312
NP_054799                                                              17    4312
NP_000129                                                              17    4312
NP_787954                                                              17    4312
NP_059130                                                              17    4312
XP_005254520                                                           17    4312
XP_005254478                                                           17    4312
NP_004516                                                              16    5631
NP_001186623                                                           16    5631
NP_001186622                                                           16    5631
NP_001186621                                                           16    5631
NP_036364                                                              16    5631
NP_003031                                                              16    5631
XP_006725534                                                           16    5631
XP_005257299                                                           16    5631
XP_006712590                                                           16    5631
XP_006712589                                                           16    5631
NP_443155                                                              16    5631
NP_004353                                                              16    7355
NP_001124147                                                           16    7355
NP_001239268                                                           16    7355
NP_001239267                                                           16    7355
NP_001785                                                              16    7355
NP_001438                                                              16    7355
NP_001207417                                                           16    7355
NP_061728                                                              16    7355
NP_055061                                                              16    7355
NP_113683                                                              16    7355
XP_006724446                                                           16    7355
XP_006714824                                                           16    7355
XP_006714125                                                           16    7355
NP_004052                                                              16    7355
NP_113684                                                              16    7355
NP_001248                                                              16    7355
NP_001207419                                                           16    7355
NP_001207418                                                           16    7355
NP_001934                                                              15    9605
NP_001267727                                                           15    9605
NP_001267726                                                           15    9605
NP_037399                                                              15    9605
NP_056262                                                              15    9605
NP_001243542                                                           15    9605
NP_789744                                                              15    9605
NP_055524                                                              15    9605
NP_653270                                                              15    9605
NP_001190194                                                           15    9605
NP_001190193                                                           15    9605
NP_036459                                                              15    9605
NP_114141                                                              15    9605
NP_872395                                                              15    9605
XP_005268855                                                           15    9605
XP_005268854                                                           15    9605
XP_005253611                                                           15    9605
XP_006719310                                                           15    9605
XP_006719309                                                           15    9605
XP_006719308                                                           15    9605
XP_005253610                                                           15    9605
XP_005263454                                                           15    9605
XP_005263453                                                           15    9605
XP_005247433                                                           15    9605
XP_006713417                                                           15    9605
XP_006713415                                                           15    9605
>NP_004351
          Length = 882

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VLDVNEA 7
           VLDVNEA
Sbjct: 477 VLDVNEA 483
>NP_005106
          Length = 893

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLDVNEAEK 9
           +LD +EAEK
Sbjct: 693 ILDQSEAEK 701
>NP_059447
          Length = 893

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLDVNEAEK 9
           +LD +EAEK
Sbjct: 693 ILDQSEAEK 701
>NP_054799
          Length = 1548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLDVNEAE 8
           VLD+N+A+
Sbjct: 779 VLDINQAD 786
>NP_000129
          Length = 2871

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LDVNEAEK 9
            LD+NE E+
Sbjct: 1890 LDINECER 1897
>NP_787954
          Length = 1551

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLDVNEAE 8
           VLD+N+A+
Sbjct: 775 VLDINQAD 782
>NP_059130
          Length = 1551

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLDVNEAE 8
           VLD+N+A+
Sbjct: 775 VLDINQAD 782
>XP_005254520
          Length = 1235

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLDVNEAE 8
           VLD+N+A+
Sbjct: 459 VLDINQAD 466
>XP_005254478
          Length = 1548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VLDVNEAE 8
           VLD+N+A+
Sbjct: 779 VLDINQAD 786
>NP_004516
          Length = 4655

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LDVNEAEK 9
            LD+NE E+
Sbjct: 4006 LDINECEQ 4013
>NP_001186623
          Length = 1227

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    LDVNEAE 8
            LD NEAE
Sbjct: 1202 LDANEAE 1208
>NP_001186622
          Length = 1232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    LDVNEAE 8
            LD NEAE
Sbjct: 1207 LDANEAE 1213
>NP_001186621
          Length = 1241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    LDVNEAE 8
            LD NEAE
Sbjct: 1216 LDANEAE 1222
>NP_036364
          Length = 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LDVNEAE 8
           L+VNEAE
Sbjct: 138 LEVNEAE 144
>NP_003031
          Length = 1241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    LDVNEAE 8
            LD NEAE
Sbjct: 1216 LDANEAE 1222
>XP_006725534
          Length = 1174

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  LDVNEAE 8
          LD NEAE
Sbjct: 59 LDTNEAE 65
>XP_005257299
          Length = 225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LDVNEAE 8
           L+VNEAE
Sbjct: 138 LEVNEAE 144
>XP_006712590
          Length = 3897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LDVNEAEK 9
            LD+NE E+
Sbjct: 3248 LDINECEQ 3255
>XP_006712589
          Length = 4660

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LDVNEAEK 9
            LD+NE E+
Sbjct: 4011 LDINECEQ 4018
>NP_443155
          Length = 1325

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDVNEAE 8
           LD NEAE
Sbjct: 210 LDTNEAE 216
>NP_004353
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LDVNEAE 8
          +DVNE+E
Sbjct: 38 IDVNESE 44
>NP_001124147
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LDVNEAE 8
          +DVNE+E
Sbjct: 38 IDVNESE 44
>NP_001239268
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VLDVNEA 7
           ++D+NEA
Sbjct: 424 IMDINEA 430
>NP_001239267
          Length = 879

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VLDVNEA 7
           ++D+NEA
Sbjct: 461 IMDINEA 467
>NP_001785
          Length = 916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VLDVNEA 7
           ++D+NEA
Sbjct: 498 IMDINEA 504
>NP_001438
          Length = 4349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    VLDVNE 6
            VLDVNE
Sbjct: 1020 VLDVNE 1025
>NP_001207417
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VLDVNE 6
           VLDVNE
Sbjct: 515 VLDVNE 520
>NP_061728
          Length = 948

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VLDVNEAE 8
           VLDVN+ E
Sbjct: 232 VLDVNDNE 239
>NP_055061
          Length = 3014

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VLDVNEAE 8
           VLDVN+ E
Sbjct: 555 VLDVNDNE 562
>NP_113683
          Length = 824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VLDVNEAE 8
           VLDVN+ E
Sbjct: 232 VLDVNDNE 239
>XP_006724446
          Length = 3019

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VLDVNEAE 8
           VLDVN+ E
Sbjct: 555 VLDVNDNE 562
>XP_006714824
          Length = 4349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    VLDVNE 6
            VLDVNE
Sbjct: 1020 VLDVNE 1025
>XP_006714125
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LDVNEAE 8
          +DVNE+E
Sbjct: 38 IDVNESE 44
>NP_004052
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VLDVNE 6
           VLDVNE
Sbjct: 479 VLDVNE 484
>NP_113684
          Length = 808

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VLDVNEAE 8
           VLDVN+ E
Sbjct: 232 VLDVNDNE 239
>NP_001248
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VLDVNE 6
           VLDVNE
Sbjct: 468 VLDVNE 473
>NP_001207419
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VLDVNE 6
           VLDVNE
Sbjct: 214 VLDVNE 219
>NP_001207418
          Length = 674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VLDVNE 6
           VLDVNE
Sbjct: 429 VLDVNE 434
>NP_001934
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLDVNEAE 8
           VLD+N+ E
Sbjct: 149 VLDINDNE 156
>NP_001267727
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LDVNEAEK 9
          +D N+AEK
Sbjct: 15 MDCNKAEK 22
>NP_001267726
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LDVNEAEK 9
          +D N+AEK
Sbjct: 15 MDCNKAEK 22
>NP_037399
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LDVNEAEK 9
           +D N+AEK
Sbjct: 280 MDCNKAEK 287
>NP_056262
          Length = 1602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLDVNEAE 8
           V+D+ EAE
Sbjct: 742 VVDIEEAE 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VLDVNEAE 8
            V+DVNE +
Sbjct: 1014 VVDVNECD 1021
>NP_001243542
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  VLDVNE 6
          +LDVNE
Sbjct: 75 ILDVNE 80
>NP_789744
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LDVNEAE 8
           LDVN+A+
Sbjct: 317 LDVNQAD 323
>NP_055524
          Length = 3546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VNEAEK 9
           +NEAEK
Sbjct: 880 INEAEK 885
>NP_653270
          Length = 266

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DVNEAEK 9
          D N+AEK
Sbjct: 90 DANQAEK 96
>NP_001190194
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LDVNEAEK 9
           +DVN +EK
Sbjct: 337 VDVNSSEK 344
>NP_001190193
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LDVNEAEK 9
           +DVN +EK
Sbjct: 352 VDVNSSEK 359
>NP_036459
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LDVNEAE 8
           LDVN+A+
Sbjct: 317 LDVNQAD 323
>NP_114141
          Length = 5635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LDVNEAEK 9
            +D+NE E+
Sbjct: 5314 MDINECEQ 5321
>NP_872395
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  VLDVNE 6
          +LDVNE
Sbjct: 90 ILDVNE 95
>XP_005268855
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LDVNEAEK 9
           +D N+AEK
Sbjct: 179 MDCNKAEK 186
>XP_005268854
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LDVNEAEK 9
           +D N+AEK
Sbjct: 244 MDCNKAEK 251
>XP_005253611
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DVNEAEK 9
          D N+AEK
Sbjct: 48 DANQAEK 54
>XP_006719310
          Length = 306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DVNEAEK 9
          D N+AEK
Sbjct: 90 DANQAEK 96
>XP_006719309
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DVNEAEK 9
          D N+AEK
Sbjct: 90 DANQAEK 96
>XP_006719308
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DVNEAEK 9
          D N+AEK
Sbjct: 90 DANQAEK 96
>XP_005253610
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  DVNEAEK 9
          D N+AEK
Sbjct: 90 DANQAEK 96
>XP_005263454
          Length = 1324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLDVNEAE 8
           V+D+ EAE
Sbjct: 464 VVDIEEAE 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLDVNEAE 8
           V+DVNE +
Sbjct: 736 VVDVNECD 743
>XP_005263453
          Length = 1613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLDVNEAE 8
           V+D+ EAE
Sbjct: 753 VVDIEEAE 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VLDVNEAE 8
            V+DVNE +
Sbjct: 1025 VVDVNECD 1032
>XP_005247433
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1 VLDVNE 6
         +LDVNE
Sbjct: 4 ILDVNE 9
>XP_006713417
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LDVNEAEK 9
           +DVN +EK
Sbjct: 408 VDVNSSEK 415
>XP_006713415
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LDVNEAEK 9
           +DVN +EK
Sbjct: 423 VDVNSSEK 430
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.123    0.294 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 494,832
Number of extensions: 1152
Number of successful extensions: 67
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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