Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              18    1935
XP_006718907                                                           18    1935
XP_006718906                                                           18    1935
XP_005271619                                                           18    1935
XP_005271618                                                           18    1935
NP_940851                                                              17    4312
NP_110433                                                              17    4312
NP_065681                                                              16    5631
NP_066124                                                              16    5631
NP_079510                                                              16    5631
NP_005036                                                              16    5631
NP_774959                                                              16    5631
NP_005287                                                              16    5631
NP_001264929                                                           16    5631
XP_005262183                                                           16    5631
XP_006724702                                                           16    5631
XP_005254755                                                           16    5631
XP_006717999                                                           16    5631
NP_653172                                                              16    7355
NP_001273719                                                           16    7355
NP_056933                                                              16    7355
NP_001192183                                                           16    7355
NP_002529                                                              16    7355
NP_003121                                                              16    7355
NP_001192184                                                           16    7355
NP_254275                                                              16    7355
NP_001243821                                                           16    7355
NP_001243820                                                           16    7355
NP_944490                                                              16    7355
XP_006726276                                                           16    7355
XP_006716160                                                           16    7355
XP_006714575                                                           16    7355
XP_005262934                                                           16    7355
NP_057245                                                              16    7355
NP_114368                                                              15    9605
NP_002810                                                              15    9605
NP_114367                                                              15    9605
NP_004930                                                              15    9605
NP_001338                                                              15    9605
NP_001159445                                                           15    9605
NP_004659                                                              15    9605
NP_036330                                                              15    9605
NP_001271268                                                           15    9605
NP_940682                                                              15    9605
NP_001271267                                                           15    9605
NP_001271269                                                           15    9605
NP_055892                                                              15    9605
NP_647450                                                              15    9605
NP_003877                                                              15    9605
NP_064578                                                              15    9605
NP_114141                                                              15    9605
XP_005259655                                                           15    9605
XP_005259654                                                           15    9605
XP_006718702                                                           15    9605
XP_006718701                                                           15    9605
XP_006718700                                                           15    9605
XP_005274169                                                           15    9605
XP_005274166                                                           15    9605
XP_005274165                                                           15    9605
XP_005274163                                                           15    9605
XP_005269501                                                           15    9605
XP_006716232                                                           15    9605
XP_006716231                                                           15    9605
XP_005246503                                                           15    9605
XP_006712464                                                           15    9605
XP_006712463                                                           15    9605
XP_006712462                                                           15    9605
XP_006712461                                                           15    9605
NP_940857                                                              15    9605
>NP_000042
          Length = 3056

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKYSSNGAI 9
           VK SSNGAI
Sbjct: 128 VKDSSNGAI 136
>XP_006718907
          Length = 3050

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKYSSNGAI 9
           VK SSNGAI
Sbjct: 128 VKDSSNGAI 136
>XP_006718906
          Length = 3056

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKYSSNGAI 9
           VK SSNGAI
Sbjct: 128 VKDSSNGAI 136
>XP_005271619
          Length = 3056

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKYSSNGAI 9
           VK SSNGAI
Sbjct: 128 VKDSSNGAI 136
>XP_005271618
          Length = 3056

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKYSSNGAI 9
           VK SSNGAI
Sbjct: 128 VKDSSNGAI 136
>NP_940851
          Length = 327

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YSSNGAI 9
           YSSNG++
Sbjct: 193 YSSNGSV 199
>NP_110433
          Length = 121

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  VKYSSNGA 8
          VKY  NGA
Sbjct: 42 VKYMKNGA 49
>NP_065681
          Length = 1072

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKYSSNGA 8
           V YSS+GA
Sbjct: 685 VSYSSSGA 692
>NP_066124
          Length = 1114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKYSSNGA 8
           V YSS+GA
Sbjct: 685 VSYSSSGA 692
>NP_079510
          Length = 305

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKYSSNGA 8
           VKY+ NG+
Sbjct: 280 VKYNGNGS 287
>NP_005036
          Length = 3460

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VKYSSNGAI 9
            ++YS+NG I
Sbjct: 1155 LQYSNNGGI 1163
>NP_774959
          Length = 3458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VKYSSNGAI 9
            ++YS+NG I
Sbjct: 1155 LQYSNNGGI 1163
>NP_005287
          Length = 370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KYSSNGAI 9
          KY+ NGA+
Sbjct: 38 KYNLNGAV 45
>NP_001264929
          Length = 370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KYSSNGAI 9
          KY+ NGA+
Sbjct: 38 KYNLNGAV 45
>XP_005262183
          Length = 370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KYSSNGAI 9
          KY+ NGA+
Sbjct: 38 KYNLNGAV 45
>XP_006724702
          Length = 370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KYSSNGAI 9
          KY+ NGA+
Sbjct: 38 KYNLNGAV 45
>XP_005254755
          Length = 305

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKYSSNGA 8
           VKY+ NG+
Sbjct: 280 VKYNGNGS 287
>XP_006717999
          Length = 1207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKYSSNGA 8
           V YSS+GA
Sbjct: 778 VSYSSSGA 785
>NP_653172
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VKYSSNGAI 9
           V+Y SNG +
Sbjct: 420 VEYLSNGGV 428
>NP_001273719
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VKYSSNGAI 9
           V+Y SNG +
Sbjct: 420 VEYLSNGGV 428
>NP_056933
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VKYSSNG 7
          ++YSSNG
Sbjct: 46 LQYSSNG 52
>NP_001192183
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YSSNGAI 9
           YSSNG +
Sbjct: 325 YSSNGKV 331
>NP_002529
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YSSNGAI 9
           YSSNG +
Sbjct: 325 YSSNGKV 331
>NP_003121
          Length = 198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KYSSNGAI 9
           +YS+NG I
Sbjct: 147 RYSTNGKI 154
>NP_001192184
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  YSSNGAI 9
          YSSNG +
Sbjct: 74 YSSNGKV 80
>NP_254275
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VKYSSNG 7
          ++YSSNG
Sbjct: 46 LQYSSNG 52
>NP_001243821
          Length = 180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KYSSNGAI 9
           +YS+NG I
Sbjct: 132 RYSTNGKI 139
>NP_001243820
          Length = 195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KYSSNGAI 9
           +YS+NG I
Sbjct: 147 RYSTNGKI 154
>NP_944490
          Length = 183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KYSSNGAI 9
           +YS+NG I
Sbjct: 132 RYSTNGKI 139
>XP_006726276
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YSSNGAI 9
           YSSNG +
Sbjct: 271 YSSNGKV 277
>XP_006716160
          Length = 113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KYSSNGAI 9
          +YS+NG I
Sbjct: 62 RYSTNGKI 69
>XP_006714575
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YSSNGAI 9
           YSSNG +
Sbjct: 271 YSSNGKV 277
>XP_005262934
          Length = 550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VKYSSNGAI 9
           V+Y SNG +
Sbjct: 415 VEYLSNGGV 423
>NP_057245
          Length = 340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KYSSNG 7
           +YSSNG
Sbjct: 188 RYSSNG 193
>NP_114368
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VKYSSNGAI 9
           V +SSNG +
Sbjct: 472 VLFSSNGGV 480
>NP_002810
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VKYSSNGAI 9
           V +SSNG +
Sbjct: 498 VLFSSNGGV 506
>NP_114367
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VKYSSNGAI 9
           V +SSNG +
Sbjct: 491 VLFSSNGGV 499
>NP_004930
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VKYSSNG 7
           VK+S NG
Sbjct: 203 VKFSKNG 209
>NP_001338
          Length = 942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YSSNGAI 9
           YSS GA+
Sbjct: 536 YSSQGAV 542
>NP_001159445
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VKYSSNG 7
           +KYSS+G
Sbjct: 330 LKYSSSG 336
>NP_004659
          Length = 1857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VKYSSNGA 8
            V+Y+S+GA
Sbjct: 1008 VQYNSHGA 1015
>NP_036330
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KYSSNGAI 9
           +YS NG I
Sbjct: 166 RYSKNGRI 173
>NP_001271268
          Length = 1303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YSSNGA 8
           YSSNG+
Sbjct: 162 YSSNGS 167
>NP_940682
          Length = 1247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YSSNGA 8
           YSSNG+
Sbjct: 162 YSSNGS 167
>NP_001271267
          Length = 1319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YSSNGA 8
           YSSNG+
Sbjct: 162 YSSNGS 167
>NP_001271269
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YSSNGA 8
           YSSNG+
Sbjct: 162 YSSNGS 167
>NP_055892
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VKYSSNG 7
           V YS+NG
Sbjct: 378 VSYSTNG 384
>NP_647450
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KYSSNGA 8
           KYS++GA
Sbjct: 704 KYSNDGA 710
>NP_003877
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KYSSNGA 8
           KYS++GA
Sbjct: 713 KYSNDGA 719
>NP_064578
          Length = 1322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSNGAI 9
           SSNGAI
Sbjct: 489 SSNGAI 494
>NP_114141
          Length = 5635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    YSSNGAI 9
            YS+NG I
Sbjct: 5612 YSANGTI 5618
>XP_005259655
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VKYSSNGAI 9
           V +SSNG +
Sbjct: 474 VLFSSNGGV 482
>XP_005259654
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VKYSSNGAI 9
           V +SSNG +
Sbjct: 500 VLFSSNGGV 508
>XP_006718702
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSNGAI 9
           SSNGAI
Sbjct: 439 SSNGAI 444
>XP_006718701
          Length = 1309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSNGAI 9
           SSNGAI
Sbjct: 490 SSNGAI 495
>XP_006718700
          Length = 1216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSNGAI 9
           SSNGAI
Sbjct: 504 SSNGAI 509
>XP_005274169
          Length = 1272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSNGAI 9
           SSNGAI
Sbjct: 453 SSNGAI 458
>XP_005274166
          Length = 1323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSNGAI 9
           SSNGAI
Sbjct: 504 SSNGAI 509
>XP_005274165
          Length = 1323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSNGAI 9
           SSNGAI
Sbjct: 490 SSNGAI 495
>XP_005274163
          Length = 1337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSNGAI 9
           SSNGAI
Sbjct: 504 SSNGAI 509
>XP_005269501
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VKYSSNG 7
           +KYSS+G
Sbjct: 551 LKYSSSG 557
>XP_006716232
          Length = 2753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VKYSSNGA 8
            V+Y+S+GA
Sbjct: 1008 VQYNSHGA 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VKYSSNGA 8
            V+Y+S+GA
Sbjct: 1904 VQYNSHGA 1911
>XP_006716231
          Length = 2753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VKYSSNGA 8
            V+Y+S+GA
Sbjct: 1008 VQYNSHGA 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VKYSSNGA 8
            V+Y+S+GA
Sbjct: 1904 VQYNSHGA 1911
>XP_005246503
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KYSSNGAI 9
           +YS NG I
Sbjct: 166 RYSKNGRI 173
>XP_006712464
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KYSSNGAI 9
           +YS NG I
Sbjct: 192 RYSKNGRI 199
>XP_006712463
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KYSSNGAI 9
           +YS NG I
Sbjct: 181 RYSKNGRI 188
>XP_006712462
          Length = 249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KYSSNGAI 9
           +YS NG I
Sbjct: 192 RYSKNGRI 199
>XP_006712461
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KYSSNGAI 9
           +YS NG I
Sbjct: 192 RYSKNGRI 199
>NP_940857
          Length = 5147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSNGAI 9
            SSNGAI
Sbjct: 3353 SSNGAI 3358
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.121    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 618,295
Number of extensions: 1129
Number of successful extensions: 71
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package