Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_002061                                                              17    4312
NP_002060                                                              17    4312
NP_001243343                                                           17    4312
NP_001269549                                                           17    4312
NP_001269547                                                           17    4312
NP_001269546                                                           17    4312
NP_001269548                                                           17    4312
NP_620073                                                              17    4312
NP_066268                                                              17    4312
NP_001159897                                                           17    4312
NP_006487                                                              17    4312
NP_005263                                                              16    5631
NP_653082                                                              16    5631
NP_000163                                                              16    5631
NP_001095856                                                           16    5631
NP_060860                                                              15    9605
NP_056127                                                              15    9605
NP_002171                                                              15    9605
XP_006724930                                                           15    9605
XP_006724929                                                           15    9605
XP_006724928                                                           15    9605
XP_006724509                                                           15    9605
XP_006724508                                                           15    9605
XP_006724507                                                           15    9605
XP_005274034                                                           15    9605
XP_005274033                                                           15    9605
XP_006714407                                                           15    9605
XP_006714406                                                           15    9605
XP_006714405                                                           15    9605
XP_005263349                                                           15    9605
XP_005263348                                                           15    9605
XP_005263347                                                           15    9605
XP_005263346                                                           15    9605
XP_005263345                                                           15    9605
XP_005263344                                                           15    9605
XP_005263343                                                           15    9605
XP_005263342                                                           15    9605
XP_005263341                                                           15    9605
XP_005263340                                                           15    9605
XP_005263339                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VKTTAVVEE 9
            VKTTA VEE
Sbjct: 1739 VKTTAAVEE 1747
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VKTTAVVEE 9
            VKTTA VEE
Sbjct: 1739 VKTTAAVEE 1747
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VKTTAVVEE 9
            VKTTA VEE
Sbjct: 1692 VKTTAAVEE 1700
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VKTTAVVEE 9
            VKTTA VEE
Sbjct: 1771 VKTTAAVEE 1779
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VKTTAVVEE 9
            VKTTA VEE
Sbjct: 1771 VKTTAAVEE 1779
>NP_002061
          Length = 355

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT +VE
Sbjct: 180 VKTTGIVE 187
>NP_002060
          Length = 354

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT +VE
Sbjct: 179 VKTTGIVE 186
>NP_001243343
          Length = 302

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT +VE
Sbjct: 127 VKTTGIVE 134
>NP_001269549
          Length = 339

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT +VE
Sbjct: 164 VKTTGIVE 171
>NP_001269547
          Length = 274

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT +VE
Sbjct: 99  VKTTGIVE 106
>NP_001269546
          Length = 303

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT +VE
Sbjct: 128 VKTTGIVE 135
>NP_001269548
          Length = 339

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT +VE
Sbjct: 164 VKTTGIVE 171
>NP_620073
          Length = 354

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT +VE
Sbjct: 180 VKTTGIVE 187
>NP_066268
          Length = 354

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT +VE
Sbjct: 180 VKTTGIVE 187
>NP_001159897
          Length = 318

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT +VE
Sbjct: 143 VKTTGIVE 150
>NP_006487
          Length = 354

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT +VE
Sbjct: 179 VKTTGIVE 186
>NP_005263
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT ++E
Sbjct: 179 VKTTGIIE 186
>NP_653082
          Length = 350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT ++E
Sbjct: 175 VKTTGIIE 182
>NP_000163
          Length = 350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT ++E
Sbjct: 175 VKTTGIIE 182
>NP_001095856
          Length = 354

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKTTAVVE 8
           VKTT ++E
Sbjct: 179 VKTTGIIE 186
>NP_060860
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKTTAVVEE 9
           V TTA+VE+
Sbjct: 124 VYTTALVED 132
>NP_056127
          Length = 5005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1614 RTTAIVE 1620
>NP_002171
          Length = 993

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   KTTAVVE 8
           KTT VVE
Sbjct: 220 KTTTVVE 226
>XP_006724930
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKTTAVVEE 9
           V TTA+VE+
Sbjct: 124 VYTTALVED 132
>XP_006724929
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKTTAVVEE 9
           V TTA+VE+
Sbjct: 124 VYTTALVED 132
>XP_006724928
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKTTAVVEE 9
           V TTA+VE+
Sbjct: 124 VYTTALVED 132
>XP_006724509
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKTTAVVEE 9
           V TTA+VE+
Sbjct: 124 VYTTALVED 132
>XP_006724508
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKTTAVVEE 9
           V TTA+VE+
Sbjct: 124 VYTTALVED 132
>XP_006724507
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKTTAVVEE 9
           V TTA+VE+
Sbjct: 124 VYTTALVED 132
>XP_005274034
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   KTTAVVE 8
           KTT VVE
Sbjct: 220 KTTTVVE 226
>XP_005274033
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   KTTAVVE 8
           KTT VVE
Sbjct: 220 KTTTVVE 226
>XP_006714407
          Length = 5004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1613 RTTAIVE 1619
>XP_006714406
          Length = 3680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1614 RTTAIVE 1620
>XP_006714405
          Length = 4103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KTTAVVE 8
           +TTA+VE
Sbjct: 691 RTTAIVE 697
>XP_005263349
          Length = 4410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 998  RTTAIVE 1004
>XP_005263348
          Length = 4443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1031 RTTAIVE 1037
>XP_005263347
          Length = 4640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1614 RTTAIVE 1620
>XP_005263346
          Length = 4983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1571 RTTAIVE 1577
>XP_005263345
          Length = 4991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1614 RTTAIVE 1620
>XP_005263344
          Length = 5005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1614 RTTAIVE 1620
>XP_005263343
          Length = 5009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1614 RTTAIVE 1620
>XP_005263342
          Length = 5025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1613 RTTAIVE 1619
>XP_005263341
          Length = 5026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1614 RTTAIVE 1620
>XP_005263340
          Length = 5026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1614 RTTAIVE 1620
>XP_005263339
          Length = 5026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KTTAVVE 8
            +TTA+VE
Sbjct: 1614 RTTAIVE 1620
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296    0.111    0.247 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 325,146
Number of extensions: 382
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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