Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           21     175
NP_055459                                                              21     175
XP_006726410                                                           21     175
XP_006711719                                                           21     175
XP_006711716                                                           21     175
XP_005273038                                                           21     175
XP_006711164                                                           21     175
NP_056477                                                              17    2528
XP_006712050                                                           17    2528
XP_005264311                                                           17    2528
XP_006712049                                                           17    2528
NP_005520                                                              17    3301
XP_006710661                                                           17    3301
XP_005245920                                                           17    3301
XP_006710660                                                           17    3301
XP_006710659                                                           17    3301
XP_006710658                                                           17    3301
XP_006710657                                                           17    3301
NP_848604                                                              16    5631
NP_065883                                                              16    5631
NP_079385                                                              16    5631
NP_001157207                                                           16    5631
XP_006725418                                                           16    5631
XP_006725417                                                           16    5631
XP_006725416                                                           16    5631
XP_006725415                                                           16    5631
XP_006725414                                                           16    5631
XP_005257754                                                           16    5631
XP_005257753                                                           16    5631
XP_006722172                                                           16    5631
XP_006722171                                                           16    5631
XP_006722170                                                           16    5631
XP_005257244                                                           16    5631
XP_005245423                                                           16    5631
XP_005245425                                                           16    5631
NP_001157915                                                           16    7355
NP_775267                                                              15    9605
NP_775268                                                              15    9605
NP_001123537                                                           15    9605
NP_775266                                                              15    9605
NP_004094                                                              15    9605
NP_036581                                                              15    9605
NP_006370                                                              15    9605
NP_004136                                                              15    9605
XP_006722821                                                           15    9605
XP_006722820                                                           15    9605
XP_005259972                                                           15    9605
XP_006722819                                                           15    9605
XP_006722818                                                           15    9605
XP_005273505                                                           15    9605
XP_005273504                                                           15    9605
XP_005250170                                                           15    9605
>NP_001185761
          Length = 2240

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VKSVRALPC 9
            VKS+RALPC
Sbjct: 2228 VKSLRALPC 2236
>NP_055459
          Length = 2346

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VKSVRALPC 9
            VKS+RALPC
Sbjct: 2334 VKSLRALPC 2342
>XP_006726410
          Length = 2087

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VKSVRALPC 9
            VKS+RALPC
Sbjct: 2075 VKSLRALPC 2083
>XP_006711719
          Length = 2302

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VKSVRALPC 9
            VKS+RALPC
Sbjct: 2290 VKSLRALPC 2298
>XP_006711716
          Length = 2411

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VKSVRALPC 9
            VKS+RALPC
Sbjct: 2399 VKSLRALPC 2407
>XP_005273038
          Length = 2509

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VKSVRALPC 9
            VKS+RALPC
Sbjct: 2497 VKSLRALPC 2505
>XP_006711164
          Length = 2087

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VKSVRALPC 9
            VKS+RALPC
Sbjct: 2075 VKSLRALPC 2083
>NP_056477
          Length = 1749

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VRALPC 9
            VRALPC
Sbjct: 1681 VRALPC 1686
>XP_006712050
          Length = 1716

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VRALPC 9
            VRALPC
Sbjct: 1648 VRALPC 1653
>XP_005264311
          Length = 1727

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VRALPC 9
            VRALPC
Sbjct: 1659 VRALPC 1664
>XP_006712049
          Length = 1728

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    VRALPC 9
            VRALPC
Sbjct: 1660 VRALPC 1665
>NP_005520
          Length = 4391

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVRALPC 9
           SVR LPC
Sbjct: 279 SVRPLPC 285
>XP_006710661
          Length = 4057

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVRALPC 9
           SVR LPC
Sbjct: 296 SVRPLPC 302
>XP_005245920
          Length = 4392

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVRALPC 9
           SVR LPC
Sbjct: 279 SVRPLPC 285
>XP_006710660
          Length = 4397

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVRALPC 9
           SVR LPC
Sbjct: 279 SVRPLPC 285
>XP_006710659
          Length = 4556

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVRALPC 9
           SVR LPC
Sbjct: 296 SVRPLPC 302
>XP_006710658
          Length = 4563

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVRALPC 9
           SVR LPC
Sbjct: 279 SVRPLPC 285
>XP_006710657
          Length = 4579

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVRALPC 9
           SVR LPC
Sbjct: 296 SVRPLPC 302
>NP_848604
          Length = 553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VKSVRAL 7
           VKSVRAL
Sbjct: 486 VKSVRAL 492
>NP_065883
          Length = 1237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KSVRALPC 9
           KSV+  PC
Sbjct: 988 KSVKKFPC 995
>NP_079385
          Length = 770

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 711 VTSIRALP 718
>NP_001157207
          Length = 970

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 911 VTSIRALP 918
>XP_006725418
          Length = 705

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 646 VTSIRALP 653
>XP_006725417
          Length = 725

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 666 VTSIRALP 673
>XP_006725416
          Length = 808

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 749 VTSIRALP 756
>XP_006725415
          Length = 990

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 931 VTSIRALP 938
>XP_006725414
          Length = 1034

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 975 VTSIRALP 982
>XP_005257754
          Length = 705

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 646 VTSIRALP 653
>XP_005257753
          Length = 707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 648 VTSIRALP 655
>XP_006722172
          Length = 808

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 749 VTSIRALP 756
>XP_006722171
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 913 VTSIRALP 920
>XP_006722170
          Length = 1016

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           V S+RALP
Sbjct: 957 VTSIRALP 964
>XP_005257244
          Length = 555

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VKSVRAL 7
           VKSVRAL
Sbjct: 488 VKSVRAL 494
>XP_005245423
          Length = 1246

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KSVRALPC 9
            KSV+  PC
Sbjct: 997  KSVKKFPC 1004
>XP_005245425
          Length = 1299

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KSVRALPC 9
            KSV+  PC
Sbjct: 1050 KSVKKFPC 1057
>NP_001157915
          Length = 1873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KSVRALPC 9
            KSV  +PC
Sbjct: 1657 KSVSVVPC 1664
>NP_775267
          Length = 967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           ++S+R LP
Sbjct: 305 IRSIRCLP 312
>NP_775268
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           ++S+R LP
Sbjct: 305 IRSIRCLP 312
>NP_001123537
          Length = 2022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           +KS++ LP
Sbjct: 747 IKSIKGLP 754
>NP_775266
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           ++S+R LP
Sbjct: 305 IRSIRCLP 312
>NP_004094
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           ++S+R LP
Sbjct: 305 IRSIRCLP 312
>NP_036581
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KSVRALPC 9
           KS+  LPC
Sbjct: 305 KSILFLPC 312
>NP_006370
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVRALP 8
           SVRALP
Sbjct: 682 SVRALP 687
>NP_004136
          Length = 2157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           +KS++ LP
Sbjct: 747 IKSIKGLP 754
>XP_006722821
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           +KS++ LP
Sbjct: 747 IKSIKGLP 754
>XP_006722820
          Length = 2140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           +KS++ LP
Sbjct: 747 IKSIKGLP 754
>XP_005259972
          Length = 2141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           +KS++ LP
Sbjct: 747 IKSIKGLP 754
>XP_006722819
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           +KS++ LP
Sbjct: 747 IKSIKGLP 754
>XP_006722818
          Length = 2157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           +KS++ LP
Sbjct: 747 IKSIKGLP 754
>XP_005273505
          Length = 997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           ++S+R LP
Sbjct: 305 IRSIRCLP 312
>XP_005273504
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKSVRALP 8
           ++S+R LP
Sbjct: 305 IRSIRCLP 312
>XP_005250170
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SVRALP 8
           SVRALP
Sbjct: 624 SVRALP 629
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.135    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 371,785
Number of extensions: 527
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package