Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              19     869
NP_899199                                                              18    1935
NP_001171547                                                           18    1935
NP_001171548                                                           18    1935
NP_001171546                                                           18    1935
NP_001664                                                              18    1935
NP_597680                                                              18    1935
NP_078907                                                              18    1935
XP_005271733                                                           18    1935
XP_006718971                                                           18    1935
XP_006718969                                                           18    1935
XP_006718968                                                           18    1935
XP_005271730                                                           18    1935
NP_599030                                                              17    2528
NP_003794                                                              17    2528
NP_062830                                                              17    2528
XP_005257062                                                           17    2528
XP_005265796                                                           17    2528
NP_001019782                                                           17    2528
NP_064615                                                              17    3301
NP_001245283                                                           17    3301
NP_775823                                                              17    3301
NP_004238                                                              17    3301
NP_001245282                                                           17    3301
NP_001136077                                                           17    3301
NP_001185619                                                           17    3301
NP_001035754                                                           17    3301
NP_001167594                                                           17    3301
XP_006722587                                                           17    3301
NP_004125                                                              17    4312
NP_001103831                                                           16    5631
NP_001103827                                                           16    5631
NP_001103826                                                           16    5631
NP_001103828                                                           16    5631
NP_001103830                                                           16    5631
NP_001103829                                                           16    5631
NP_001001673                                                           16    5631
NP_001276039                                                           16    5631
NP_665699                                                              16    5631
XP_006720205                                                           16    5631
NP_061119                                                              16    7355
NP_060225                                                              16    7355
NP_061833                                                              16    7355
XP_005264656                                                           16    7355
NP_115688                                                              16    7355
NP_001269354                                                           15    9605
NP_006563                                                              15    9605
NP_113628                                                              15    9605
XP_006715232                                                           15    9605
XP_005249381                                                           15    9605
XP_005249380                                                           15    9605
XP_005249379                                                           15    9605
XP_005249377                                                           15    9605
XP_005249376                                                           15    9605
XP_005249375                                                           15    9605
XP_005249374                                                           15    9605
XP_005249373                                                           15    9605
XP_005249372                                                           15    9605
XP_005249371                                                           15    9605
XP_005249370                                                           15    9605
XP_005249369                                                           15    9605
XP_005249368                                                           15    9605
XP_005249367                                                           15    9605
XP_006714215                                                           15    9605
XP_006714214                                                           15    9605
XP_005262915                                                           15    9605
NP_001004058                                                           15    9605
NP_055806                                                              15    9605
>NP_000312
          Length = 928

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VKNVYFK 7
           VKNVYFK
Sbjct: 288 VKNVYFK 294
>NP_899199
          Length = 561

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           VKN +FKIL
Sbjct: 477 VKNSWFKIL 485
>NP_001171547
          Length = 478

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           VKN +FKIL
Sbjct: 394 VKNSWFKIL 402
>NP_001171548
          Length = 478

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           VKN +FKIL
Sbjct: 394 VKNSWFKIL 402
>NP_001171546
          Length = 540

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           VKN +FKIL
Sbjct: 456 VKNSWFKIL 464
>NP_001664
          Length = 561

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           VKN +FKIL
Sbjct: 477 VKNSWFKIL 485
>NP_597680
          Length = 561

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           VKN +FKIL
Sbjct: 477 VKNSWFKIL 485
>NP_078907
          Length = 507

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KNVYFKIL 9
           KNVY+K L
Sbjct: 317 KNVYYKFL 324
>XP_005271733
          Length = 329

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KNVYFKIL 9
           KNVY+K L
Sbjct: 139 KNVYYKFL 146
>XP_006718971
          Length = 329

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KNVYFKIL 9
           KNVY+K L
Sbjct: 139 KNVYYKFL 146
>XP_006718969
          Length = 329

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KNVYFKIL 9
           KNVY+K L
Sbjct: 139 KNVYYKFL 146
>XP_006718968
          Length = 329

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KNVYFKIL 9
           KNVY+K L
Sbjct: 139 KNVYYKFL 146
>XP_005271730
          Length = 648

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KNVYFKIL 9
           KNVY+K L
Sbjct: 458 KNVYYKFL 465
>NP_599030
          Length = 190

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           V+ VYFKIL
Sbjct: 119 VEPVYFKIL 127
>NP_003794
          Length = 1685

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VKNVYFKI 8
            +KNVY K+
Sbjct: 1095 IKNVYLKV 1102
>NP_062830
          Length = 1589

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VKNVYFKI 8
            +KNVY K+
Sbjct: 999  IKNVYLKV 1006
>XP_005257062
          Length = 202

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           V+ VYFKIL
Sbjct: 119 VEPVYFKIL 127
>XP_005265796
          Length = 880

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1 VKNVYFKIL 9
         +KN+YF+++
Sbjct: 1 MKNLYFRVI 9
>NP_001019782
          Length = 880

 Score = 17.3 bits (33), Expect =  2528
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1 VKNVYFKIL 9
         +KN+YF+++
Sbjct: 1 MKNLYFRVI 9
>NP_064615
          Length = 473

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVYFKIL 9
           NVYFK++
Sbjct: 94  NVYFKLM 100
>NP_001245283
          Length = 962

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           ++NV FKIL
Sbjct: 774 IRNVKFKIL 782
>NP_775823
          Length = 430

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  VKNVYF 6
          VKNVYF
Sbjct: 88 VKNVYF 93
>NP_004238
          Length = 972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           ++NV FKIL
Sbjct: 784 IRNVKFKIL 792
>NP_001245282
          Length = 972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           ++NV FKIL
Sbjct: 784 IRNVKFKIL 792
>NP_001136077
          Length = 937

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           ++NV FKIL
Sbjct: 749 IRNVKFKIL 757
>NP_001185619
          Length = 520

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVYFKIL 9
           NVYFK++
Sbjct: 94  NVYFKLM 100
>NP_001035754
          Length = 794

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVYFKIL 9
           NVYFK++
Sbjct: 94  NVYFKLM 100
>NP_001167594
          Length = 685

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVYFKIL 9
           N+YFK+L
Sbjct: 253 NIYFKML 259
>XP_006722587
          Length = 685

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVYFKIL 9
           N+YFK+L
Sbjct: 253 NIYFKML 259
>NP_004125
          Length = 679

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           +KNV FKI+
Sbjct: 137 IKNVPFKIV 145
>NP_001103831
          Length = 210

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KNVYFK 7
           KNVY+K
Sbjct: 95  KNVYYK 100
>NP_001103827
          Length = 205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KNVYFK 7
          KNVY+K
Sbjct: 90 KNVYYK 95
>NP_001103826
          Length = 205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KNVYFK 7
          KNVY+K
Sbjct: 90 KNVYYK 95
>NP_001103828
          Length = 210

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KNVYFK 7
           KNVY+K
Sbjct: 95  KNVYYK 100
>NP_001103830
          Length = 210

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KNVYFK 7
           KNVY+K
Sbjct: 95  KNVYYK 100
>NP_001103829
          Length = 210

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KNVYFK 7
           KNVY+K
Sbjct: 95  KNVYYK 100
>NP_001001673
          Length = 205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KNVYFK 7
          KNVY+K
Sbjct: 90 KNVYYK 95
>NP_001276039
          Length = 205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KNVYFK 7
          KNVY+K
Sbjct: 90 KNVYYK 95
>NP_665699
          Length = 333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KNVYFK 7
           KN+YFK
Sbjct: 315 KNMYFK 320
>XP_006720205
          Length = 205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  KNVYFK 7
          KNVY+K
Sbjct: 90 KNVYYK 95
>NP_061119
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VKNVYF 6
           +KNVYF
Sbjct: 346 LKNVYF 351
>NP_060225
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VKNVYFKIL 9
           +KN YFK L
Sbjct: 94  LKNKYFKEL 102
>NP_061833
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   KNVYFK 7
           KN+Y+K
Sbjct: 193 KNIYYK 198
>XP_005264656
          Length = 214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  VKNVYFKI 8
          +K++Y+KI
Sbjct: 85 LKDIYYKI 92
>NP_115688
          Length = 244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  VKNVYFKI 8
          +K++Y+KI
Sbjct: 85 LKDIYYKI 92
>NP_001269354
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           +KNV FK++
Sbjct: 118 IKNVPFKMV 126
>NP_006563
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           +KNV FK++
Sbjct: 213 IKNVPFKMV 221
>NP_113628
          Length = 232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           +KN+ F+IL
Sbjct: 115 LKNLVFRIL 123
>XP_006715232
          Length = 7498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3278 LENIFYKLL 3286
>XP_005249381
          Length = 7281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 2952 LENIFYKLL 2960
>XP_005249380
          Length = 7607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3278 LENIFYKLL 3286
>XP_005249379
          Length = 7633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3304 LENIFYKLL 3312
>XP_005249377
          Length = 7640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3311 LENIFYKLL 3319
>XP_005249376
          Length = 7647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3318 LENIFYKLL 3326
>XP_005249375
          Length = 7680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3351 LENIFYKLL 3359
>XP_005249374
          Length = 7709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3489 LENIFYKLL 3497
>XP_005249373
          Length = 7723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3394 LENIFYKLL 3402
>XP_005249372
          Length = 7785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3456 LENIFYKLL 3464
>XP_005249371
          Length = 7788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3489 LENIFYKLL 3497
>XP_005249370
          Length = 7794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3489 LENIFYKLL 3497
>XP_005249369
          Length = 7797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3468 LENIFYKLL 3476
>XP_005249368
          Length = 7812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3489 LENIFYKLL 3497
>XP_005249367
          Length = 7818

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 9/9 (100%)

Query: 1    VKNVYFKIL 9
            ++N+++K+L
Sbjct: 3489 LENIFYKLL 3497
>XP_006714215
          Length = 3544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           V+N YF++L
Sbjct: 458 VQNKYFEML 466
>XP_006714214
          Length = 3544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           V+N YF++L
Sbjct: 458 VQNKYFEML 466
>XP_005262915
          Length = 3544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           V+N YF++L
Sbjct: 458 VQNKYFEML 466
>NP_001004058
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VKNVYFKI 8
           VKN ++K+
Sbjct: 297 VKNAFYKL 304
>NP_055806
          Length = 3526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKNVYFKIL 9
           V+N YF++L
Sbjct: 440 VQNKYFEML 448
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.154    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 487,443
Number of extensions: 799
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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