Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     509
NP_001091680                                                           20     509
NP_001091679                                                           20     509
XP_006713048                                                           20     509
XP_006713047                                                           20     509
XP_006713046                                                           20     509
XP_005264943                                                           20     509
NP_057095                                                              18    1935
XP_005245942                                                           18    1935
NP_002221                                                              17    2528
NP_068831                                                              17    2528
XP_006721941                                                           17    2528
XP_006721940                                                           17    2528
XP_006721939                                                           17    2528
XP_006721938                                                           17    2528
XP_006721937                                                           17    2528
XP_006721936                                                           17    2528
XP_006721935                                                           17    2528
XP_006721934                                                           17    2528
XP_005257370                                                           17    2528
XP_006723798                                                           17    4312
NP_620482                                                              16    5631
NP_001077084                                                           16    5631
NP_001120680                                                           16    5631
NP_852129                                                              16    5631
NP_852127                                                              16    5631
NP_852128                                                              16    5631
NP_852120                                                              16    5631
NP_852130                                                              16    5631
NP_852119                                                              16    5631
NP_852106                                                              16    5631
XP_006714305                                                           16    5631
XP_005263139                                                           16    5631
XP_006712362                                                           16    5631
XP_006711811                                                           16    5631
XP_005273119                                                           16    5631
XP_005273120                                                           16    5631
XP_005273118                                                           16    5631
XP_005273117                                                           16    5631
XP_005273116                                                           16    5631
XP_006711810                                                           16    5631
XP_006711809                                                           16    5631
XP_006711808                                                           16    5631
XP_006711807                                                           16    5631
XP_006711806                                                           16    5631
XP_006711805                                                           16    5631
XP_006711804                                                           16    5631
XP_006711803                                                           16    5631
XP_006711802                                                           16    5631
XP_006711801                                                           16    5631
XP_006711800                                                           16    5631
NP_722516                                                              16    5631
NP_852121                                                              16    5631
NP_056321                                                              16    7355
NP_003556                                                              16    7355
NP_001275661                                                           16    7355
NP_060939                                                              16    7355
NP_001275662                                                           16    7355
XP_005257564                                                           16    7355
NP_008864                                                              15    9605
NP_064505                                                              15    9605
XP_006712699                                                           15    9605
XP_006712698                                                           15    9605
XP_006712697                                                           15    9605
>NP_001895
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKMLASPVD 9
           VKML SPVD
Sbjct: 241 VKMLGSPVD 249
>NP_001091680
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKMLASPVD 9
           VKML SPVD
Sbjct: 241 VKMLGSPVD 249
>NP_001091679
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKMLASPVD 9
           VKML SPVD
Sbjct: 241 VKMLGSPVD 249
>XP_006713048
          Length = 720

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKMLASPVD 9
           VKML SPVD
Sbjct: 241 VKMLGSPVD 249
>XP_006713047
          Length = 774

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKMLASPVD 9
           VKML SPVD
Sbjct: 234 VKMLGSPVD 242
>XP_006713046
          Length = 774

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKMLASPVD 9
           VKML SPVD
Sbjct: 234 VKMLGSPVD 242
>XP_005264943
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VKMLASPVD 9
           VKML SPVD
Sbjct: 241 VKMLGSPVD 249
>NP_057095
          Length = 373

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  VKMLASPVD 9
          VKMLA+P++
Sbjct: 75 VKMLAAPIN 83
>XP_005245942
          Length = 401

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           VKMLA+P++
Sbjct: 103 VKMLAAPIN 111
>NP_002221
          Length = 745

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           V+ML+SPV+
Sbjct: 232 VRMLSSPVE 240
>NP_068831
          Length = 745

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           V+ML+SPV+
Sbjct: 232 VRMLSSPVE 240
>XP_006721941
          Length = 745

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           V+ML+SPV+
Sbjct: 232 VRMLSSPVE 240
>XP_006721940
          Length = 745

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           V+ML+SPV+
Sbjct: 232 VRMLSSPVE 240
>XP_006721939
          Length = 745

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           V+ML+SPV+
Sbjct: 232 VRMLSSPVE 240
>XP_006721938
          Length = 745

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           V+ML+SPV+
Sbjct: 232 VRMLSSPVE 240
>XP_006721937
          Length = 745

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           V+ML+SPV+
Sbjct: 232 VRMLSSPVE 240
>XP_006721936
          Length = 745

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           V+ML+SPV+
Sbjct: 232 VRMLSSPVE 240
>XP_006721935
          Length = 762

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           V+ML+SPV+
Sbjct: 249 VRMLSSPVE 257
>XP_006721934
          Length = 783

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           V+ML+SPV+
Sbjct: 270 VRMLSSPVE 278
>XP_005257370
          Length = 783

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VKMLASPVD 9
           V+ML+SPV+
Sbjct: 270 VRMLSSPVE 278
>XP_006723798
          Length = 916

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          KM+ASP D
Sbjct: 51 KMIASPED 58
>NP_620482
          Length = 1341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KMLASPVD 9
            KML+SP D
Sbjct: 1265 KMLSSPED 1272
>NP_001077084
          Length = 1314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KMLASPVD 9
            KML+SP D
Sbjct: 1238 KMLSSPED 1245
>NP_001120680
          Length = 2002

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VKMLASPV 8
            V+MLA PV
Sbjct: 1454 VRMLAEPV 1461
>NP_852129
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>NP_852127
          Length = 164

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 109 RMLAMPID 116
>NP_852128
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>NP_852120
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>NP_852130
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>NP_852119
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>NP_852106
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>XP_006714305
          Length = 1902

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VKMLASPV 8
            V+MLA PV
Sbjct: 1354 VRMLAEPV 1361
>XP_005263139
          Length = 2002

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VKMLASPV 8
            V+MLA PV
Sbjct: 1454 VRMLAEPV 1461
>XP_006712362
          Length = 1350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    KMLASPVD 9
            KML+SP D
Sbjct: 1274 KMLSSPED 1281
>XP_006711811
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>XP_005273119
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>XP_005273120
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>XP_005273118
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>XP_005273117
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>XP_005273116
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>XP_006711810
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 115 RMLAMPID 122
>XP_006711809
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 115 RMLAMPID 122
>XP_006711808
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 115 RMLAMPID 122
>XP_006711807
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 115 RMLAMPID 122
>XP_006711806
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 115 RMLAMPID 122
>XP_006711805
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 115 RMLAMPID 122
>XP_006711804
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 115 RMLAMPID 122
>XP_006711803
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 115 RMLAMPID 122
>XP_006711802
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 115 RMLAMPID 122
>XP_006711801
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 115 RMLAMPID 122
>XP_006711800
          Length = 170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMLASPVD 9
           +MLA P+D
Sbjct: 115 RMLAMPID 122
>NP_722516
          Length = 1826

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KMLASPVD 9
            KM+ +PVD
Sbjct: 1561 KMIVNPVD 1568
>NP_852121
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMLASPVD 9
          +MLA P+D
Sbjct: 73 RMLAMPID 80
>NP_056321
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VKMLASPVD 9
          ++ML  PVD
Sbjct: 72 LRMLTDPVD 80
>NP_003556
          Length = 1050

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   KMLASPVD 9
           K LASP D
Sbjct: 326 KTLASPAD 333
>NP_001275661
          Length = 1127

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKMLASPV 8
           VK+L SPV
Sbjct: 114 VKLLESPV 121
>NP_060939
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKMLASPV 8
           VK+L SPV
Sbjct: 114 VKLLESPV 121
>NP_001275662
          Length = 1127

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKMLASPV 8
           VK+L SPV
Sbjct: 114 VKLLESPV 121
>XP_005257564
          Length = 1125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKMLASPV 8
           VK+L SPV
Sbjct: 114 VKLLESPV 121
>NP_008864
          Length = 718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VKMLASPVD 9
           +KML +P D
Sbjct: 248 LKMLRNPTD 256
>NP_064505
          Length = 1555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KMLASPVD 9
           ++LASPV+
Sbjct: 333 RILASPVE 340
>XP_006712699
          Length = 1544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KMLASPVD 9
           ++LASPV+
Sbjct: 322 RILASPVE 329
>XP_006712698
          Length = 1547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KMLASPVD 9
           ++LASPV+
Sbjct: 333 RILASPVE 340
>XP_006712697
          Length = 1549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KMLASPVD 9
           ++LASPV+
Sbjct: 327 RILASPVE 334
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.129    0.342 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 652,322
Number of extensions: 580
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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