Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              19     869
NP_444254                                                              19     869
NP_444253                                                              19     869
NP_444255                                                              19     869
XP_005247551                                                           19     869
XP_005247550                                                           19     869
XP_006713712                                                           19     869
XP_005247549                                                           19     869
NP_620706                                                              17    4312
NP_003066                                                              17    4312
NP_001123892                                                           17    4312
NP_061987                                                              17    4312
NP_004223                                                              17    4312
XP_006722640                                                           17    4312
XP_005266840                                                           17    4312
XP_005269161                                                           17    4312
XP_005269160                                                           17    4312
XP_005269159                                                           17    4312
XP_005269158                                                           17    4312
XP_006717209                                                           17    4312
XP_006717208                                                           17    4312
XP_006717207                                                           17    4312
NP_000224                                                              16    5631
NP_055029                                                              16    5631
NP_758424                                                              16    7355
NP_061142                                                              16    7355
NP_001229814                                                           16    7355
NP_036552                                                              16    7355
NP_001248359                                                           16    7355
NP_001136126                                                           16    7355
NP_001136125                                                           16    7355
NP_001129514                                                           16    7355
NP_079543                                                              16    7355
NP_065997                                                              15    9605
NP_079096                                                              15    9605
NP_066990                                                              15    9605
NP_001245236                                                           15    9605
NP_997193                                                              15    9605
NP_620125                                                              15    9605
NP_001245233                                                           15    9605
NP_001245235                                                           15    9605
XP_005252170                                                           15    9605
XP_005252168                                                           15    9605
XP_006717258                                                           15    9605
XP_005252166                                                           15    9605
XP_006712900                                                           15    9605
XP_005263899                                                           15    9605
XP_006712898                                                           15    9605
XP_006712897                                                           15    9605
XP_005263897                                                           15    9605
XP_006712896                                                           15    9605
XP_005263896                                                           15    9605
XP_005263895                                                           15    9605
XP_005263894                                                           15    9605
XP_006712894                                                           15    9605
XP_005263892                                                           15    9605
XP_006712891                                                           15    9605
XP_005263893                                                           15    9605
>NP_444256
          Length = 1794

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KKVSTKTL 9
           KKVSTKTL
Sbjct: 834 KKVSTKTL 841
>NP_444254
          Length = 1845

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KKVSTKTL 9
           KKVSTKTL
Sbjct: 834 KKVSTKTL 841
>NP_444253
          Length = 1914

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KKVSTKTL 9
           KKVSTKTL
Sbjct: 903 KKVSTKTL 910
>NP_444255
          Length = 1863

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KKVSTKTL 9
           KKVSTKTL
Sbjct: 903 KKVSTKTL 910
>XP_005247551
          Length = 1855

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KKVSTKTL 9
           KKVSTKTL
Sbjct: 844 KKVSTKTL 851
>XP_005247550
          Length = 1856

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KKVSTKTL 9
           KKVSTKTL
Sbjct: 913 KKVSTKTL 920
>XP_006713712
          Length = 1923

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KKVSTKTL 9
           KKVSTKTL
Sbjct: 913 KKVSTKTL 920
>XP_005247549
          Length = 1924

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KKVSTKTL 9
           KKVSTKTL
Sbjct: 913 KKVSTKTL 920
>NP_620706
          Length = 1130

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKVSTKTL 9
           KK+S KTL
Sbjct: 270 KKISAKTL 277
>NP_003066
          Length = 1214

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKVSTKTL 9
           KK+S KTL
Sbjct: 270 KKISAKTL 277
>NP_001123892
          Length = 1152

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKVSTKTL 9
           KK+S KTL
Sbjct: 270 KKISAKTL 277
>NP_061987
          Length = 900

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   KKVSTKTL 9
           KKVS KTL
Sbjct: 588 KKVSEKTL 595
>NP_004223
          Length = 535

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1 VKKVSTKTL 9
         +KK+S KTL
Sbjct: 1 MKKISLKTL 9
>XP_006722640
          Length = 535

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1 VKKVSTKTL 9
         +KK+S KTL
Sbjct: 1 MKKISLKTL 9
>XP_005266840
          Length = 535

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1 VKKVSTKTL 9
         +KK+S KTL
Sbjct: 1 MKKISLKTL 9
>XP_005269161
          Length = 1151

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKVSTKTL 9
           KK+S KTL
Sbjct: 270 KKISAKTL 277
>XP_005269160
          Length = 1213

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKVSTKTL 9
           KK+S KTL
Sbjct: 270 KKISAKTL 277
>XP_005269159
          Length = 1244

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKVSTKTL 9
           KK+S KTL
Sbjct: 270 KKISAKTL 277
>XP_005269158
          Length = 1245

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KKVSTKTL 9
           KK+S KTL
Sbjct: 270 KKISAKTL 277
>XP_006717209
          Length = 812

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   KKVSTKTL 9
           KKVS KTL
Sbjct: 588 KKVSEKTL 595
>XP_006717208
          Length = 838

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   KKVSTKTL 9
           KKVS KTL
Sbjct: 588 KKVSEKTL 595
>XP_006717207
          Length = 861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   KKVSTKTL 9
           KKVS KTL
Sbjct: 588 KKVSEKTL 595
>NP_000224
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKKVSTKTL 9
           V+KV+ KTL
Sbjct: 308 VRKVNNKTL 316
>NP_055029
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  KKVSTKT 8
          K+VSTKT
Sbjct: 42 KRVSTKT 48
>NP_758424
          Length = 1642

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    VKKVSTK 7
            VKKV+TK
Sbjct: 1311 VKKVATK 1317
>NP_061142
          Length = 1642

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    VKKVSTK 7
            VKKV+TK
Sbjct: 1311 VKKVATK 1317
>NP_001229814
          Length = 125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  VKKVSTKT 8
          +KK+ TKT
Sbjct: 67 IKKMQTKT 74
>NP_036552
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VKKVSTKTL 9
           +KK+STK L
Sbjct: 420 LKKLSTKRL 428
>NP_001248359
          Length = 199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VKKVSTK 7
           +KKVSTK
Sbjct: 171 LKKVSTK 177
>NP_001136126
          Length = 161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VKKVSTK 7
           +KKVSTK
Sbjct: 133 LKKVSTK 139
>NP_001136125
          Length = 166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VKKVSTK 7
           +KKVSTK
Sbjct: 138 LKKVSTK 144
>NP_001129514
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VKKVSTK 7
           +KKVSTK
Sbjct: 171 LKKVSTK 177
>NP_079543
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VKKVSTK 7
           +KKVSTK
Sbjct: 110 LKKVSTK 116
>NP_065997
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKKVSTKT 8
           +KKVST T
Sbjct: 297 LKKVSTTT 304
>NP_079096
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKKVSTKT 8
           +KKVST T
Sbjct: 297 LKKVSTTT 304
>NP_066990
          Length = 269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KKVSTK 7
           KKVSTK
Sbjct: 108 KKVSTK 113
>NP_001245236
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 260 KVSTKSL 266
>NP_997193
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 326 KVSTKSL 332
>NP_620125
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 326 KVSTKSL 332
>NP_001245233
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 323 KVSTKSL 329
>NP_001245235
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 260 KVSTKSL 266
>XP_005252170
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKKVSTKT 8
           +KKVST T
Sbjct: 312 LKKVSTTT 319
>XP_005252168
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKKVSTKT 8
           +KKVST T
Sbjct: 312 LKKVSTTT 319
>XP_006717258
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKKVSTKT 8
           +KKVST T
Sbjct: 312 LKKVSTTT 319
>XP_005252166
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VKKVSTKT 8
           +KKVST T
Sbjct: 297 LKKVSTTT 304
>XP_006712900
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 264 KVSTKSL 270
>XP_005263899
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 302 KVSTKSL 308
>XP_006712898
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 306 KVSTKSL 312
>XP_006712897
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 330 KVSTKSL 336
>XP_005263897
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 368 KVSTKSL 374
>XP_006712896
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 372 KVSTKSL 378
>XP_005263896
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 428 KVSTKSL 434
>XP_005263895
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 428 KVSTKSL 434
>XP_005263894
          Length = 210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 158 KVSTKSL 164
>XP_006712894
          Length = 298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 246 KVSTKSL 252
>XP_005263892
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 302 KVSTKSL 308
>XP_006712891
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 368 KVSTKSL 374
>XP_005263893
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KVSTKTL 9
           KVSTK+L
Sbjct: 428 KVSTKSL 434
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.302    0.113    0.255 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 311,270
Number of extensions: 492
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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