Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055524                                                              18    1935
NP_000590                                                              18    1935
NP_001186091                                                           16    5631
NP_001186090                                                           16    5631
NP_006668                                                              16    5631
NP_001186089                                                           16    5631
XP_005264888                                                           16    5631
XP_006713016                                                           16    5631
XP_005264887                                                           16    5631
XP_006713015                                                           16    5631
XP_006713014                                                           16    5631
XP_006713013                                                           16    5631
XP_006713012                                                           16    5631
XP_006713011                                                           16    5631
XP_005264886                                                           16    5631
XP_006713010                                                           16    5631
XP_005264885                                                           16    5631
XP_005264884                                                           16    5631
XP_005264883                                                           16    5631
XP_005264882                                                           16    5631
XP_006713009                                                           16    5631
XP_005264881                                                           16    5631
XP_005264880                                                           16    5631
NP_061985                                                              16    7355
NP_077270                                                              16    7355
NP_001153517                                                           16    7355
NP_005260                                                              16    7355
NP_001161081                                                           16    7355
NP_001229436                                                           16    7355
NP_061168                                                              16    7355
NP_620714                                                              16    7355
NP_001229435                                                           16    7355
NP_001229547                                                           16    7355
NP_001229546                                                           16    7355
NP_001229434                                                           16    7355
NP_057283                                                              16    7355
NP_004284                                                              16    7355
XP_006722681                                                           16    7355
XP_006722680                                                           16    7355
XP_006722679                                                           16    7355
XP_005268856                                                           16    7355
XP_006718519                                                           16    7355
XP_006718518                                                           16    7355
XP_006718517                                                           16    7355
XP_006718516                                                           16    7355
XP_005273885                                                           16    7355
XP_005273884                                                           16    7355
XP_005273883                                                           16    7355
XP_005273882                                                           16    7355
XP_006717389                                                           16    7355
XP_005252374                                                           16    7355
XP_005249355                                                           16    7355
NP_037380                                                              16    7355
NP_004612                                                              15    9605
NP_079316                                                              15    9605
NP_036277                                                              15    9605
NP_542376                                                              15    9605
NP_004740                                                              15    9605
NP_004361                                                              15    9605
NP_112162                                                              15    9605
NP_954573                                                              15    9605
NP_001248763                                                           15    9605
XP_006726617                                                           15    9605
XP_006720409                                                           15    9605
XP_006718961                                                           15    9605
XP_006715397                                                           15    9605
XP_006710039                                                           15    9605
NP_001004726                                                           15    9605
>NP_055524
          Length = 3546

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VKFVGGKQN 9
            +K +GGK N
Sbjct: 3099 IKLIGGKSN 3107
>NP_000590
          Length = 272

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KFVGGKQN 9
           KFVGG +N
Sbjct: 164 KFVGGAEN 171
>NP_001186091
          Length = 1372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>NP_001186090
          Length = 1384

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>NP_006668
          Length = 1318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>NP_001186089
          Length = 1419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>XP_005264888
          Length = 1268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 139 VRFAGGQQ 146
>XP_006713016
          Length = 1404

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 139 VRFAGGQQ 146
>XP_005264887
          Length = 1322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>XP_006713015
          Length = 1367

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 139 VRFAGGQQ 146
>XP_006713014
          Length = 1368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 139 VRFAGGQQ 146
>XP_006713013
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 139 VRFAGGQQ 146
>XP_006713012
          Length = 1373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>XP_006713011
          Length = 1382

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>XP_005264886
          Length = 1386

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>XP_006713010
          Length = 1405

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 139 VRFAGGQQ 146
>XP_005264885
          Length = 1406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 139 VRFAGGQQ 146
>XP_005264884
          Length = 1408

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 139 VRFAGGQQ 146
>XP_005264883
          Length = 1421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>XP_005264882
          Length = 1421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>XP_006713009
          Length = 1422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>XP_005264881
          Length = 1423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>XP_005264880
          Length = 1423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           V+F GG+Q
Sbjct: 154 VRFAGGQQ 161
>NP_061985
          Length = 2146

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VKFVGGKQ 8
           + FVGG Q
Sbjct: 952 IAFVGGSQ 959
>NP_077270
          Length = 298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           +K+VGG Q
Sbjct: 115 LKYVGGDQ 122
>NP_001153517
          Length = 978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KFVGGKQ 8
           KF+GG Q
Sbjct: 801 KFLGGSQ 807
>NP_005260
          Length = 1106

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KFVGGKQ 8
           KF+GG Q
Sbjct: 929 KFLGGSQ 935
>NP_001161081
          Length = 1065

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KFVGGKQ 8
           KF+GG Q
Sbjct: 888 KFLGGSQ 894
>NP_001229436
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FVGGKQ 8
           +VGGKQ
Sbjct: 367 YVGGKQ 372
>NP_061168
          Length = 197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VKFVGGKQN 9
           VKF G KQ+
Sbjct: 155 VKFDGNKQH 163
>NP_620714
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGGKQN 9
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>NP_001229435
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FVGGKQ 8
           +VGGKQ
Sbjct: 367 YVGGKQ 372
>NP_001229547
          Length = 114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VKFVGGKQN 9
          VKF G KQ+
Sbjct: 72 VKFDGNKQH 80
>NP_001229546
          Length = 142

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VKFVGGKQN 9
           VKF G KQ+
Sbjct: 100 VKFDGNKQH 108
>NP_001229434
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FVGGKQ 8
           +VGGKQ
Sbjct: 441 YVGGKQ 446
>NP_057283
          Length = 103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  VKFVGGKQ 8
          VKF GG++
Sbjct: 25 VKFQGGRE 32
>NP_004284
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FVGGKQ 8
           +VGGKQ
Sbjct: 441 YVGGKQ 446
>XP_006722681
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VKFVGGKQ 8
           + FVGG Q
Sbjct: 171 IAFVGGSQ 178
>XP_006722680
          Length = 1636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VKFVGGKQ 8
           + FVGG Q
Sbjct: 952 IAFVGGSQ 959
>XP_006722679
          Length = 2128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VKFVGGKQ 8
           + FVGG Q
Sbjct: 952 IAFVGGSQ 959
>XP_005268856
          Length = 978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KFVGGKQ 8
           KF+GG Q
Sbjct: 801 KFLGGSQ 807
>XP_006718519
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGGKQN 9
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_006718518
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  FVGGKQN 9
          F GGKQ+
Sbjct: 38 FAGGKQD 44
>XP_006718517
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGGKQN 9
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_006718516
          Length = 566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGGKQN 9
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_005273885
          Length = 591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGGKQN 9
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_005273884
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGGKQN 9
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_005273883
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGGKQN 9
           F GGKQ+
Sbjct: 153 FAGGKQD 159
>XP_005273882
          Length = 679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FVGGKQN 9
           F GGKQ+
Sbjct: 238 FAGGKQD 244
>XP_006717389
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FVGGKQ 8
           +VGGKQ
Sbjct: 441 YVGGKQ 446
>XP_005252374
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FVGGKQ 8
           +VGGKQ
Sbjct: 441 YVGGKQ 446
>XP_005249355
          Length = 289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKFVGGKQ 8
           +K+VGG Q
Sbjct: 115 LKYVGGDQ 122
>NP_037380
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VKFVGGKQ 8
           VKF G KQ
Sbjct: 99  VKFEGNKQ 106
>NP_004612
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   FVGGKQN 9
           ++G KQN
Sbjct: 659 YIGAKQN 665
>NP_079316
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   VKFVGGKQ 8
           V+F+GG++
Sbjct: 156 VEFIGGEK 163
>NP_036277
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   VKFVGGKQN 9
           V F G K+N
Sbjct: 103 VAFTGAKEN 111
>NP_542376
          Length = 1899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   VGGKQN 9
           +GG+QN
Sbjct: 637 IGGRQN 642
>NP_004740
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VKFVGGK 7
           ++F+GGK
Sbjct: 437 IQFLGGK 443
>NP_004361
          Length = 3063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    VGGKQN 9
            +GG+QN
Sbjct: 1801 IGGRQN 1806
>NP_112162
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VKFVGGK 7
           ++F+GGK
Sbjct: 327 IQFLGGK 333
>NP_954573
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VKFVGGK 7
           ++F+GGK
Sbjct: 327 IQFLGGK 333
>NP_001248763
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VKFVGGK 7
           ++F+GGK
Sbjct: 448 IQFLGGK 454
>XP_006726617
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KFVGGKQN 9
            +F+G KQN
Sbjct: 1527 EFMGHKQN 1534
>XP_006720409
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KFVGGKQN 9
            +F+G KQN
Sbjct: 1527 EFMGHKQN 1534
>XP_006718961
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   FVGGKQN 9
           ++G KQN
Sbjct: 659 YIGAKQN 665
>XP_006715397
          Length = 2972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4    VGGKQN 9
            +GG+QN
Sbjct: 1710 IGGRQN 1715
>XP_006710039
          Length = 1584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KFVGGKQN 9
            +F+G KQN
Sbjct: 1423 EFMGHKQN 1430
>NP_001004726
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   KFVGGK 7
           +F+GGK
Sbjct: 298 RFIGGK 303
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.141    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 632,505
Number of extensions: 772
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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