Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              19     869
NP_775656                                                              17    3301
NP_002596                                                              17    3301
NP_001230066                                                           17    3301
NP_777576                                                              17    3301
NP_001025025                                                           17    3301
NP_001025022                                                           17    3301
NP_003710                                                              17    3301
XP_006720631                                                           17    3301
XP_006720630                                                           17    3301
XP_005254990                                                           17    3301
XP_005248681                                                           17    3301
XP_005248680                                                           17    3301
XP_006714790                                                           17    3301
XP_005248678                                                           17    3301
XP_006714789                                                           17    3301
XP_006714788                                                           17    3301
NP_001025024                                                           17    3301
NP_078886                                                              17    4312
XP_005247819                                                           17    4312
XP_005247818                                                           17    4312
NP_112554                                                              16    5631
NP_068743                                                              16    5631
NP_001273188                                                           16    5631
NP_001165439                                                           16    5631
NP_542166                                                              16    5631
NP_056357                                                              16    5631
NP_872309                                                              16    5631
XP_005253047                                                           16    5631
XP_005253046                                                           16    5631
XP_005253045                                                           16    5631
XP_005253044                                                           16    5631
XP_006718316                                                           16    5631
NP_001136093                                                           16    7355
NP_004248                                                              16    7355
NP_057405                                                              16    7355
XP_006712924                                                           16    7355
XP_006712923                                                           16    7355
NP_001034782                                                           15    9605
NP_001122108                                                           15    9605
NP_004531                                                              15    9605
XP_006724072                                                           15    9605
XP_005261045                                                           15    9605
XP_006724071                                                           15    9605
XP_006724070                                                           15    9605
XP_006715792                                                           15    9605
XP_006715791                                                           15    9605
XP_006715790                                                           15    9605
XP_006715789                                                           15    9605
XP_006715788                                                           15    9605
>NP_004351
          Length = 882

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VINIINADL 9
           VINII+ADL
Sbjct: 611 VINIIDADL 619
>NP_775656
          Length = 783

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 350 VINIINA 356
>NP_002596
          Length = 829

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 396 VINIINA 402
>NP_001230066
          Length = 757

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 324 VINIINA 330
>NP_777576
          Length = 1749

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VINIINADL 9
           VIN++N D+
Sbjct: 878 VINLLNCDI 886
>NP_001025025
          Length = 838

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 409 VINIINA 415
>NP_001025022
          Length = 788

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 359 VINIINA 365
>NP_003710
          Length = 885

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 456 VINIINA 462
>XP_006720631
          Length = 582

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 396 VINIINA 402
>XP_006720630
          Length = 582

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 149 VINIINA 155
>XP_005254990
          Length = 639

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 206 VINIINA 212
>XP_005248681
          Length = 783

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 354 VINIINA 360
>XP_005248680
          Length = 784

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 355 VINIINA 361
>XP_006714790
          Length = 859

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 430 VINIINA 436
>XP_005248678
          Length = 884

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 455 VINIINA 461
>XP_006714789
          Length = 905

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 476 VINIINA 482
>XP_006714788
          Length = 906

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 477 VINIINA 483
>NP_001025024
          Length = 865

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   VINIINA 7
           VINIINA
Sbjct: 436 VINIINA 442
>NP_078886
          Length = 488

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INIINADL 9
           IN++N DL
Sbjct: 220 INVVNPDL 227
>XP_005247819
          Length = 280

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INIINADL 9
           IN++N DL
Sbjct: 220 INVVNPDL 227
>XP_005247818
          Length = 460

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   INIINADL 9
           IN++N DL
Sbjct: 220 INVVNPDL 227
>NP_112554
          Length = 651

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VINIINADL 9
           V+N++ ADL
Sbjct: 224 VLNVVPADL 232
>NP_068743
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VINIINADL 9
           V+N++ ADL
Sbjct: 224 VLNVVPADL 232
>NP_001273188
          Length = 144

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VINIINADL 9
          V+NI +ADL
Sbjct: 90 VLNIASADL 98
>NP_001165439
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VINIINADL 9
           V+N++ ADL
Sbjct: 224 VLNVVPADL 232
>NP_542166
          Length = 1272

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   NIINAD 8
           NIINAD
Sbjct: 293 NIINAD 298
>NP_056357
          Length = 1272

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   NIINAD 8
           NIINAD
Sbjct: 293 NIINAD 298
>NP_872309
          Length = 191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VINIINADL 9
           V+NI +ADL
Sbjct: 137 VLNIASADL 145
>XP_005253047
          Length = 551

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VINIINADL 9
           V+N++ ADL
Sbjct: 224 VLNVVPADL 232
>XP_005253046
          Length = 703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VINIINADL 9
           V+N++ ADL
Sbjct: 224 VLNVVPADL 232
>XP_005253045
          Length = 734

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VINIINADL 9
           V+N++ ADL
Sbjct: 224 VLNVVPADL 232
>XP_005253044
          Length = 765

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VINIINADL 9
           V+N++ ADL
Sbjct: 224 VLNVVPADL 232
>XP_006718316
          Length = 765

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VINIINADL 9
           V+N++ ADL
Sbjct: 224 VLNVVPADL 232
>NP_001136093
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   INIINADL 9
           +NI+N D+
Sbjct: 510 VNIVNGDV 517
>NP_004248
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   INIINADL 9
           +NI+N D+
Sbjct: 510 VNIVNGDV 517
>NP_057405
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VINIINAD 8
           V N+INAD
Sbjct: 122 VENLINAD 129
>XP_006712924
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   INIINADL 9
           +NI+N D+
Sbjct: 510 VNIVNGDV 517
>XP_006712923
          Length = 824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   INIINADL 9
           +NI+N D+
Sbjct: 510 VNIVNGDV 517
>NP_001034782
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VINIINADL 9
           V+NI N DL
Sbjct: 197 VLNIDNPDL 205
>NP_001122108
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NIINADL 9
           NI+N DL
Sbjct: 157 NIVNIDL 163
>NP_004531
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VINIINAD 8
           V NIIN+D
Sbjct: 268 VRNIINSD 275
>XP_006724072
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VINIINAD 8
           V NIIN+D
Sbjct: 104 VRNIINSD 111
>XP_005261045
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VINIINAD 8
           V NIIN+D
Sbjct: 104 VRNIINSD 111
>XP_006724071
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VINIINAD 8
           V NIIN+D
Sbjct: 268 VRNIINSD 275
>XP_006724070
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VINIINAD 8
           V NIIN+D
Sbjct: 268 VRNIINSD 275
>XP_006715792
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NIINADL 9
           NI+N DL
Sbjct: 157 NIVNIDL 163
>XP_006715791
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NIINADL 9
           NI+N DL
Sbjct: 157 NIVNIDL 163
>XP_006715790
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NIINADL 9
           NI+N DL
Sbjct: 157 NIVNIDL 163
>XP_006715789
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NIINADL 9
           NI+N DL
Sbjct: 157 NIVNIDL 163
>XP_006715788
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NIINADL 9
           NI+N DL
Sbjct: 157 NIVNIDL 163
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.150    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 411,890
Number of extensions: 927
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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