Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001121619                                                           18    1482
NP_000258                                                              18    1482
NP_001035957                                                           18    1482
XP_006721991                                                           18    1482
XP_006721990                                                           18    1482
XP_006721989                                                           18    1482
XP_005258041                                                           18    1482
XP_006721988                                                           18    1482
XP_006721987                                                           18    1482
XP_006721986                                                           18    1482
XP_005258040                                                           18    1482
XP_006721985                                                           18    1482
NP_004203                                                              18    1482
NP_001243514                                                           17    4312
NP_001003794                                                           17    4312
NP_009214                                                              17    4312
NP_001135817                                                           17    4312
NP_001135815                                                           17    4312
NP_001135816                                                           17    4312
XP_005247151                                                           17    4312
XP_005247150                                                           17    4312
NP_004063                                                              17    4312
NP_872577                                                              16    5631
NP_000186                                                              16    5631
NP_001073950                                                           16    5631
NP_006181                                                              16    5631
XP_005269816                                                           16    5631
XP_005269815                                                           16    5631
XP_005269813                                                           16    5631
XP_005269814                                                           16    5631
XP_005269812                                                           16    5631
XP_005267232                                                           16    5631
XP_005267230                                                           16    5631
XP_005267229                                                           16    5631
XP_005267228                                                           16    5631
XP_005267227                                                           16    5631
XP_005267226                                                           16    5631
XP_006712618                                                           16    5631
NP_001004731                                                           16    5631
NP_001026976                                                           16    7355
NP_000126                                                              15    9605
NP_057336                                                              15    9605
NP_001018122                                                           15    9605
NP_001273096                                                           15    9605
NP_066919                                                              15    9605
NP_001003406                                                           15    9605
NP_001001959                                                           15    9605
XP_006725598                                                           15    9605
XP_006726299                                                           15    9605
XP_006724411                                                           15    9605
XP_005256351                                                           15    9605
XP_006721230                                                           15    9605
XP_006719145                                                           15    9605
XP_006712120                                                           15    9605
XP_005264512                                                           15    9605
XP_005264511                                                           15    9605
XP_006712119                                                           15    9605
XP_005264510                                                           15    9605
XP_006712118                                                           15    9605
XP_005264509                                                           15    9605
XP_005264508                                                           15    9605
XP_006712117                                                           15    9605
XP_005264507                                                           15    9605
XP_005264506                                                           15    9605
NP_076410                                                              15    9605
NP_006840                                                              15    9605
>NP_001121619
          Length = 593

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 341 VIFLLVQSM 349
>NP_000258
          Length = 2818

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 341 VIFLLVQSM 349
>NP_001035957
          Length = 2839

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 341 VIFLLVQSM 349
>XP_006721991
          Length = 1632

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 341 VIFLLVQSM 349
>XP_006721990
          Length = 2823

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 341 VIFLLVQSM 349
>XP_006721989
          Length = 2823

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 341 VIFLLVQSM 349
>XP_005258041
          Length = 2836

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 341 VIFLLVQSM 349
>XP_006721988
          Length = 2846

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 341 VIFLLVQSM 349
>XP_006721987
          Length = 2849

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 341 VIFLLVQSM 349
>XP_006721986
          Length = 2854

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 328 VIFLLVQSM 336
>XP_005258040
          Length = 2857

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 341 VIFLLVQSM 349
>XP_006721985
          Length = 2867

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           VIFLLV SM
Sbjct: 341 VIFLLVQSM 349
>NP_004203
          Length = 658

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   VIFLLVHS 8
           VIF+LVHS
Sbjct: 114 VIFVLVHS 121
>NP_001243514
          Length = 283

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IFLLVHSM 9
           +FLL HSM
Sbjct: 126 VFLLGHSM 133
>NP_001003794
          Length = 303

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IFLLVHSM 9
           +FLL HSM
Sbjct: 116 VFLLGHSM 123
>NP_009214
          Length = 313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IFLLVHSM 9
           +FLL HSM
Sbjct: 126 VFLLGHSM 133
>NP_001135817
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FLLVHSM 9
           FLL+H+M
Sbjct: 117 FLLIHNM 123
>NP_001135815
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FLLVHSM 9
           FLL+H+M
Sbjct: 117 FLLIHNM 123
>NP_001135816
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FLLVHSM 9
           FLL+H+M
Sbjct: 117 FLLIHNM 123
>XP_005247151
          Length = 247

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IFLLVHSM 9
          +FLL HSM
Sbjct: 90 VFLLGHSM 97
>XP_005247150
          Length = 277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IFLLVHSM 9
          +FLL HSM
Sbjct: 90 VFLLGHSM 97
>NP_004063
          Length = 371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FLLVHSM 9
           FLL+H+M
Sbjct: 115 FLLIHNM 121
>NP_872577
          Length = 324

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FLLVHS 8
           FLLVHS
Sbjct: 210 FLLVHS 215
>NP_000186
          Length = 700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FLLVHS 8
           FLLVHS
Sbjct: 210 FLLVHS 215
>NP_001073950
          Length = 814

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFLLVHSM 9
           +FL +HSM
Sbjct: 255 LFLFLHSM 262
>NP_006181
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IFLLVHSM 9
           +FLL+H++
Sbjct: 388 LFLLIHNL 395
>XP_005269816
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  FLLVHS 8
          FLLVHS
Sbjct: 87 FLLVHS 92
>XP_005269815
          Length = 667

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FLLVHS 8
           FLLVHS
Sbjct: 210 FLLVHS 215
>XP_005269813
          Length = 700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FLLVHS 8
           FLLVHS
Sbjct: 210 FLLVHS 215
>XP_005269814
          Length = 700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FLLVHS 8
           FLLVHS
Sbjct: 210 FLLVHS 215
>XP_005269812
          Length = 700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FLLVHS 8
           FLLVHS
Sbjct: 210 FLLVHS 215
>XP_005267232
          Length = 437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFLLVHSM 9
           +FL +HSM
Sbjct: 255 LFLFLHSM 262
>XP_005267230
          Length = 649

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IFLLVHSM 9
          +FL +HSM
Sbjct: 90 LFLFLHSM 97
>XP_005267229
          Length = 721

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFLLVHSM 9
           +FL +HSM
Sbjct: 255 LFLFLHSM 262
>XP_005267228
          Length = 813

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFLLVHSM 9
           +FL +HSM
Sbjct: 254 LFLFLHSM 261
>XP_005267227
          Length = 814

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFLLVHSM 9
           +FL +HSM
Sbjct: 255 LFLFLHSM 262
>XP_005267226
          Length = 814

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IFLLVHSM 9
           +FL +HSM
Sbjct: 255 LFLFLHSM 262
>XP_006712618
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IFLLVHSM 9
           +FLL+H++
Sbjct: 388 LFLLIHNL 395
>NP_001004731
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VIFLLVH 7
           V+FLL+H
Sbjct: 95  VMFLLIH 101
>NP_001026976
          Length = 508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           +IFL+VH +
Sbjct: 493 LIFLVVHRL 501
>NP_000126
          Length = 1455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FLLVHSM 9
           +LL HSM
Sbjct: 154 YLLAHSM 160
>NP_057336
          Length = 4857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3715 LLFLLCHS 3722
>NP_001018122
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FLLVHSM 9
           +LL HSM
Sbjct: 154 YLLAHSM 160
>NP_001273096
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FLLVHSM 9
           +LL HSM
Sbjct: 154 YLLAHSM 160
>NP_066919
          Length = 2223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LLVHSM 9
            LL+HSM
Sbjct: 1478 LLIHSM 1483
>NP_001003406
          Length = 2188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LLVHSM 9
            LL+HSM
Sbjct: 1443 LLIHSM 1448
>NP_001001959
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VIFLLVHSM 9
          VIFLL++ +
Sbjct: 29 VIFLLIYCL 37
>XP_006725598
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           ++FLL+ S+
Sbjct: 133 IVFLLISSL 141
>XP_006726299
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           ++FLL+ S+
Sbjct: 133 IVFLLISSL 141
>XP_006724411
          Length = 1528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LLVHSM 9
           LL+HSM
Sbjct: 783 LLIHSM 788
>XP_005256351
          Length = 1463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FLLVHSM 9
           +LL HSM
Sbjct: 154 YLLAHSM 160
>XP_006721230
          Length = 1412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FLLVHSM 9
           +LL HSM
Sbjct: 154 YLLAHSM 160
>XP_006719145
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           ++FLL+ S+
Sbjct: 133 IVFLLISSL 141
>XP_006712120
          Length = 4812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3670 LLFLLCHS 3677
>XP_005264512
          Length = 4840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3698 LLFLLCHS 3705
>XP_005264511
          Length = 4847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3742 LLFLLCHS 3749
>XP_006712119
          Length = 4851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3709 LLFLLCHS 3716
>XP_005264510
          Length = 4861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3719 LLFLLCHS 3726
>XP_006712118
          Length = 4864

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3722 LLFLLCHS 3729
>XP_005264509
          Length = 4870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3728 LLFLLCHS 3735
>XP_005264508
          Length = 4875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3733 LLFLLCHS 3740
>XP_006712117
          Length = 4878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3736 LLFLLCHS 3743
>XP_005264507
          Length = 4880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3738 LLFLLCHS 3745
>XP_005264506
          Length = 4884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VIFLLVHS 8
            ++FLL HS
Sbjct: 3742 LLFLLCHS 3749
>NP_076410
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VIFLLVHSM 9
           ++FLL+ S+
Sbjct: 133 IVFLLISSL 141
>NP_006840
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   FLLVHSM 9
           FL+ HSM
Sbjct: 250 FLVTHSM 256
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.355    0.156    0.447 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 553,944
Number of extensions: 1090
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.0 bits)
S2: 28 (15.4 bits)

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