Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              19     869
NP_001338                                                              18    1135
NP_001158238                                                           17    3301
NP_008816                                                              17    3301
XP_005256014                                                           17    3301
NP_001186732                                                           17    4312
NP_077298                                                              17    4312
NP_085146                                                              17    4312
NP_663693                                                              17    4312
XP_006712165                                                           17    4312
NP_056471                                                              17    4312
NP_001278253                                                           16    5631
NP_001019554                                                           16    5631
NP_055718                                                              16    5631
XP_006722053                                                           16    5631
XP_006722052                                                           16    5631
XP_006719740                                                           16    5631
XP_006719739                                                           16    5631
XP_006719738                                                           16    5631
XP_005269272                                                           16    5631
NP_001164560                                                           16    7355
NP_060033                                                              16    7355
NP_065118                                                              16    7355
NP_060158                                                              16    7355
NP_001266280                                                           16    7355
NP_001266279                                                           16    7355
XP_005252120                                                           16    7355
XP_005252119                                                           16    7355
XP_006717212                                                           16    7355
XP_006713272                                                           16    7355
XP_005265295                                                           16    7355
XP_006710378                                                           16    7355
NP_008941                                                              15    9605
NP_001278405                                                           15    9605
NP_620416                                                              15    9605
NP_001188394                                                           15    9605
NP_001070949                                                           15    9605
NP_001070948                                                           15    9605
NP_001070947                                                           15    9605
NP_001070937                                                           15    9605
NP_001070942                                                           15    9605
NP_001070946                                                           15    9605
NP_001070938                                                           15    9605
NP_001070945                                                           15    9605
NP_001070941                                                           15    9605
NP_001070943                                                           15    9605
NP_001070940                                                           15    9605
NP_001070950                                                           15    9605
NP_001070944                                                           15    9605
NP_001070939                                                           15    9605
NP_005113                                                              15    9605
NP_004530                                                              15    9605
NP_001107580                                                           15    9605
NP_055025                                                              15    9605
NP_001003927                                                           15    9605
NP_775798                                                              15    9605
NP_001128119                                                           15    9605
NP_112196                                                              15    9605
NP_940997                                                              15    9605
XP_006725362                                                           15    9605
XP_006722616                                                           15    9605
XP_005266833                                                           15    9605
XP_005266831                                                           15    9605
XP_005266830                                                           15    9605
XP_005266757                                                           15    9605
XP_006721713                                                           15    9605
XP_005267440                                                           15    9605
XP_005267439                                                           15    9605
XP_005267438                                                           15    9605
XP_006713972                                                           15    9605
XP_006713971                                                           15    9605
XP_005245754                                                           15    9605
XP_005245751                                                           15    9605
XP_005245750                                                           15    9605
>NP_004295
          Length = 1620

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VHKLRRAKQ 9
           V KLRRAKQ
Sbjct: 132 VRKLRRAKQ 140
>NP_001338
          Length = 942

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VHKLRRAKQ 9
           VH LR+AKQ
Sbjct: 910 VHMLRKAKQ 918
>NP_001158238
          Length = 2789

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VHKLRRAKQ 9
           +HKL+RA Q
Sbjct: 656 LHKLKRALQ 664
>NP_008816
          Length = 3703

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VHKLRRAKQ 9
            +HKL+RA Q
Sbjct: 1570 LHKLKRALQ 1578
>XP_005256014
          Length = 3702

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VHKLRRAKQ 9
            +HKL+RA Q
Sbjct: 1569 LHKLKRALQ 1577
>NP_001186732
          Length = 294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  VHKLRRAK 8
          +HKLRR +
Sbjct: 46 IHKLRRLR 53
>NP_077298
          Length = 300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  VHKLRRAK 8
          +HKLRR +
Sbjct: 52 IHKLRRLR 59
>NP_085146
          Length = 348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VHKLRRAK 8
           VH LRR+K
Sbjct: 244 VHTLRRSK 251
>NP_663693
          Length = 351

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VHKLRRAK 8
           VH LRR+K
Sbjct: 247 VHTLRRSK 254
>XP_006712165
          Length = 300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  VHKLRRAK 8
          +HKLRR +
Sbjct: 52 IHKLRRLR 59
>NP_056471
          Length = 1882

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VHKLRRAK 8
           +H+LRR K
Sbjct: 722 IHRLRRKK 729
>NP_001278253
          Length = 2639

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HKLRRAKQ 9
            HKL RAK+
Sbjct: 2212 HKLLRAKK 2219
>NP_001019554
          Length = 2385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    VHKLRR 6
            +HKLRR
Sbjct: 1571 IHKLRR 1576
>NP_055718
          Length = 2363

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    VHKLRR 6
            +HKLRR
Sbjct: 1571 IHKLRR 1576
>XP_006722053
          Length = 2608

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HKLRRAKQ 9
            HKL RAK+
Sbjct: 2181 HKLLRAKK 2188
>XP_006722052
          Length = 2631

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    HKLRRAKQ 9
            HKL RAK+
Sbjct: 2204 HKLLRAKK 2211
>XP_006719740
          Length = 1863

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    VHKLRR 6
            +HKLRR
Sbjct: 1071 IHKLRR 1076
>XP_006719739
          Length = 2306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    VHKLRR 6
            +HKLRR
Sbjct: 1514 IHKLRR 1519
>XP_006719738
          Length = 2340

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    VHKLRR 6
            +HKLRR
Sbjct: 1548 IHKLRR 1553
>XP_005269272
          Length = 2356

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    VHKLRR 6
            +HKLRR
Sbjct: 1571 IHKLRR 1576
>NP_001164560
          Length = 869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VHKLRRA 7
           +HKLR+A
Sbjct: 803 LHKLRKA 809
>NP_060033
          Length = 739

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KLRRAKQ 9
           KLR+AKQ
Sbjct: 460 KLRQAKQ 466
>NP_065118
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HKLRRAKQ 9
           HK R+AK+
Sbjct: 176 HKKRKAKE 183
>NP_060158
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  HKLRRAKQ 9
          H++RRA++
Sbjct: 54 HRIRRAEE 61
>NP_001266280
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HKLRRAKQ 9
          HK R+AK+
Sbjct: 83 HKKRKAKE 90
>NP_001266279
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  HKLRRAKQ 9
          HK R+AK+
Sbjct: 39 HKKRKAKE 46
>XP_005252120
          Length = 193

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  HKLRRAKQ 9
          H++RRA++
Sbjct: 54 HRIRRAEE 61
>XP_005252119
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  HKLRRAKQ 9
          H++RRA++
Sbjct: 54 HRIRRAEE 61
>XP_006717212
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  HKLRRAKQ 9
          H++RRA++
Sbjct: 54 HRIRRAEE 61
>XP_006713272
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KLRRAKQ 9
           KLR+AKQ
Sbjct: 316 KLRQAKQ 322
>XP_005265295
          Length = 711

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KLRRAKQ 9
           KLR+AKQ
Sbjct: 432 KLRQAKQ 438
>XP_006710378
          Length = 1478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    HKLRRAKQ 9
            H+LR AK+
Sbjct: 1401 HELRNAKE 1408
>NP_008941
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HKLRRA 7
           HK+RRA
Sbjct: 345 HKVRRA 350
>NP_001278405
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HKLRRA 7
           HK+RRA
Sbjct: 237 HKVRRA 242
>NP_620416
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HKLRRA 7
           HKLRR+
Sbjct: 418 HKLRRS 423
>NP_001188394
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HKLRRA 7
           HKLRR+
Sbjct: 418 HKLRRS 423
>NP_001070949
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 89 LRRAKQ 94
>NP_001070948
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 89 LRRAKQ 94
>NP_001070947
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 60 LRRAKQ 65
>NP_001070937
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 89 LRRAKQ 94
>NP_001070942
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 89 LRRAKQ 94
>NP_001070946
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 89 LRRAKQ 94
>NP_001070938
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 60 LRRAKQ 65
>NP_001070945
          Length = 306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 60 LRRAKQ 65
>NP_001070941
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 60 LRRAKQ 65
>NP_001070943
          Length = 267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 60 LRRAKQ 65
>NP_001070940
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 60 LRRAKQ 65
>NP_001070950
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 89 LRRAKQ 94
>NP_001070944
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 60 LRRAKQ 65
>NP_001070939
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 89 LRRAKQ 94
>NP_005113
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 89 LRRAKQ 94
>NP_004530
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VHKLRR 6
           VH+LRR
Sbjct: 134 VHRLRR 139
>NP_001107580
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VHKLRRAK 8
           +H L+RAK
Sbjct: 347 LHDLKRAK 354
>NP_055025
          Length = 236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VHKLRRAKQ 9
           V  LRR+KQ
Sbjct: 163 VSSLRRSKQ 171
>NP_001003927
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VHKLRRAKQ 9
           V  LRR+KQ
Sbjct: 186 VSSLRRSKQ 194
>NP_775798
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  HKLRRAK 8
          H+LRRA+
Sbjct: 75 HQLRRAQ 81
>NP_001128119
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HKLRRAKQ 9
           H LR+AK+
Sbjct: 800 HVLRKAKE 807
>NP_112196
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HKLRRAKQ 9
           HKLRR  Q
Sbjct: 135 HKLRRHLQ 142
>NP_940997
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HKLRRAKQ 9
           H LR+AK+
Sbjct: 716 HVLRKAKE 723
>XP_006725362
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HKLRRA 7
           HK+RRA
Sbjct: 159 HKVRRA 164
>XP_006722616
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HKLRRA 7
           HKLRR+
Sbjct: 243 HKLRRS 248
>XP_005266833
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HKLRRA 7
           HKLRR+
Sbjct: 418 HKLRRS 423
>XP_005266831
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HKLRRA 7
           HKLRR+
Sbjct: 418 HKLRRS 423
>XP_005266830
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HKLRRA 7
           HKLRR+
Sbjct: 418 HKLRRS 423
>XP_005266757
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VHKLRR 6
           VH+LRR
Sbjct: 133 VHRLRR 138
>XP_006721713
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HKLRRA 7
           HK+RRA
Sbjct: 159 HKVRRA 164
>XP_005267440
          Length = 341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  HKLRRAK 8
          H+LRRA+
Sbjct: 75 HQLRRAQ 81
>XP_005267439
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HKLRRAK 8
           H+LRRA+
Sbjct: 107 HQLRRAQ 113
>XP_005267438
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HKLRRAK 8
           H+LRRA+
Sbjct: 107 HQLRRAQ 113
>XP_006713972
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HKLRRAKQ 9
           H LR+AK+
Sbjct: 737 HVLRKAKE 744
>XP_006713971
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HKLRRAKQ 9
           H LR+AK+
Sbjct: 821 HVLRKAKE 828
>XP_005245754
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LRRAKQ 9
          LRRAKQ
Sbjct: 89 LRRAKQ 94
>XP_005245751
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LRRAKQ 9
           LRRAKQ
Sbjct: 161 LRRAKQ 166
>XP_005245750
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LRRAKQ 9
           LRRAKQ
Sbjct: 161 LRRAKQ 166
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.131    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 538,244
Number of extensions: 838
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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