Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000318                                                              18    1935
NP_055078                                                              17    2528
NP_443179                                                              17    2528
NP_647473                                                              17    2528
NP_001240795                                                           17    2528
NP_005548                                                              17    3301
NP_001195                                                              17    3301
NP_000517                                                              17    3301
NP_064612                                                              17    4312
XP_006724319                                                           17    4312
XP_006724318                                                           17    4312
XP_006724317                                                           17    4312
XP_005259901                                                           17    4312
XP_005259899                                                           17    4312
XP_005259898                                                           17    4312
XP_005256332                                                           17    4312
NP_848591                                                              17    4312
NP_065955                                                              16    5631
NP_001154826                                                           16    5631
XP_006723364                                                           16    5631
XP_005259166                                                           16    5631
XP_005259165                                                           16    5631
XP_005259164                                                           16    5631
XP_006714452                                                           16    5631
XP_005263363                                                           16    5631
XP_005263362                                                           16    5631
XP_006714426                                                           16    5631
XP_006714425                                                           16    5631
XP_006714424                                                           16    5631
XP_006714423                                                           16    5631
XP_006714420                                                           16    5631
XP_006714419                                                           16    5631
XP_006714418                                                           16    5631
XP_006714417                                                           16    5631
XP_005263359                                                           16    5631
XP_006714416                                                           16    5631
XP_006714415                                                           16    5631
XP_006714414                                                           16    5631
XP_006714413                                                           16    5631
XP_006714412                                                           16    5631
XP_006714411                                                           16    5631
XP_006714410                                                           16    5631
XP_006714409                                                           16    5631
XP_006714408                                                           16    5631
NP_006100                                                              16    7355
NP_073616                                                              16    7355
NP_001269884                                                           16    7355
XP_006717299                                                           16    7355
XP_005272263                                                           16    7355
NP_619526                                                              16    7355
NP_000949                                                              15    9605
NP_004647                                                              15    9605
NP_071496                                                              15    9605
NP_110435                                                              15    9605
XP_006721644                                                           15    9605
XP_005256863                                                           15    9605
XP_005248384                                                           15    9605
XP_005248383                                                           15    9605
>NP_000318
          Length = 351

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  VGVGSSRVS 9
          VGVG+SR S
Sbjct: 79 VGVGASRAS 87
>NP_055078
          Length = 716

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VGVGSSRV 8
           VGVG+SR+
Sbjct: 356 VGVGASRI 363
>NP_443179
          Length = 2170

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VGVGSSRVS 9
           VGV SSRVS
Sbjct: 410 VGVRSSRVS 418
>NP_647473
          Length = 773

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VGVGSSRV 8
           VGVG+SR+
Sbjct: 413 VGVGASRI 420
>NP_001240795
          Length = 683

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VGVGSSRV 8
           VGVG+SR+
Sbjct: 323 VGVGASRI 330
>NP_005548
          Length = 473

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VGVGSSRVS 9
          +G GSSR+S
Sbjct: 24 IGGGSSRIS 32
>NP_001195
          Length = 1038

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VGVGSSRVS 9
          +G+G SR+S
Sbjct: 44 LGIGESRIS 52
>NP_000517
          Length = 472

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VGVGSSRVS 9
          +G GSSR+S
Sbjct: 24 IGGGSSRIS 32
>NP_064612
          Length = 894

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VGVGSSRVS 9
           VGVG SR++
Sbjct: 514 VGVGISRIA 522
>XP_006724319
          Length = 452

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GVGSSRVS 9
           G+G SRVS
Sbjct: 265 GIGPSRVS 272
>XP_006724318
          Length = 456

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GVGSSRVS 9
           G+G SRVS
Sbjct: 269 GIGPSRVS 276
>XP_006724317
          Length = 492

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GVGSSRVS 9
           G+G SRVS
Sbjct: 305 GIGPSRVS 312
>XP_005259901
          Length = 412

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1 VGVGSSRVS 9
         +GVG+ RVS
Sbjct: 1 MGVGAGRVS 9
>XP_005259899
          Length = 441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1 VGVGSSRVS 9
         +GVG+ RVS
Sbjct: 1 MGVGAGRVS 9
>XP_005259898
          Length = 442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1 VGVGSSRVS 9
         +GVG+ RVS
Sbjct: 1 MGVGAGRVS 9
>XP_005256332
          Length = 507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VGVGSSRVS 9
           VGVG SR++
Sbjct: 365 VGVGISRIA 373
>NP_848591
          Length = 491

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VGVGSSRV 8
           +GVGSSR+
Sbjct: 224 LGVGSSRM 231
>NP_065955
          Length = 779

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VGVGSSRVS 9
           +G+GS RVS
Sbjct: 555 LGLGSPRVS 563
>NP_001154826
          Length = 583

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VGVGSSRVS 9
           +G+GS RVS
Sbjct: 530 LGLGSPRVS 538
>XP_006723364
          Length = 637

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VGVGSSRVS 9
           +G+GS RVS
Sbjct: 530 LGLGSPRVS 538
>XP_005259166
          Length = 595

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VGVGSSRVS 9
           +G+GS RVS
Sbjct: 555 LGLGSPRVS 563
>XP_005259165
          Length = 662

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VGVGSSRVS 9
           +G+GS RVS
Sbjct: 555 LGLGSPRVS 563
>XP_005259164
          Length = 754

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VGVGSSRVS 9
           +G+GS RVS
Sbjct: 530 LGLGSPRVS 538
>XP_006714452
          Length = 707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_005263363
          Length = 1092

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_005263362
          Length = 1117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714426
          Length = 1145

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714425
          Length = 1155

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 114 GVGSSRL 120
>XP_006714424
          Length = 1186

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 145 GVGSSRL 151
>XP_006714423
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 224 GVGSSRL 230
>XP_006714420
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 224 GVGSSRL 230
>XP_006714419
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 224 GVGSSRL 230
>XP_006714418
          Length = 1300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714417
          Length = 1319

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_005263359
          Length = 1340

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714416
          Length = 1346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 305 GVGSSRL 311
>XP_006714415
          Length = 1347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714414
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 328 GVGSSRL 334
>XP_006714413
          Length = 1369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 328 GVGSSRL 334
>XP_006714412
          Length = 1372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714411
          Length = 1377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 336 GVGSSRL 342
>XP_006714410
          Length = 1385

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714409
          Length = 1400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>XP_006714408
          Length = 1400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVGSSRV 8
           GVGSSR+
Sbjct: 359 GVGSSRL 365
>NP_006100
          Length = 637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GVGSSRVS 9
          G G SRVS
Sbjct: 8  GAGGSRVS 15
>NP_073616
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GVGSSRV 8
          G GSSRV
Sbjct: 75 GAGSSRV 81
>NP_001269884
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GVGSSRVS 9
          G G SRVS
Sbjct: 8  GAGGSRVS 15
>XP_006717299
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GVGSSRV 8
          G GSSRV
Sbjct: 75 GAGSSRV 81
>XP_005272263
          Length = 778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GVGSSRV 8
          G GSSRV
Sbjct: 75 GAGSSRV 81
>NP_619526
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GVGSSRV 8
          G GSSRV
Sbjct: 75 GAGSSRV 81
>NP_000949
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VGVGSSRV 8
           +G+GSSR+
Sbjct: 156 MGLGSSRL 163
>NP_004647
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GVGSSRV 8
           GVG SRV
Sbjct: 380 GVGRSRV 386
>NP_071496
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GVGSSRVS 9
           G+GSSR S
Sbjct: 137 GMGSSRES 144
>NP_110435
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GVGSSRVS 9
           G+GSSR S
Sbjct: 328 GLGSSRPS 335
>XP_006721644
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GVGSSRVS 9
           G+GSSR S
Sbjct: 328 GLGSSRPS 335
>XP_005256863
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GVGSSRVS 9
           G+GSSR S
Sbjct: 328 GLGSSRPS 335
>XP_005248384
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VGVGSSRV 8
           +G+GSSR+
Sbjct: 156 MGLGSSRL 163
>XP_005248383
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VGVGSSRV 8
           +G+GSSR+
Sbjct: 156 MGLGSSRL 163
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.124    0.311 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 402,763
Number of extensions: 465
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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