Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_361014                                                              20     299
NP_001243998                                                           20     299
NP_000771                                                              17    2528
XP_006723584                                                           17    3301
XP_006723583                                                           17    3301
XP_006723582                                                           17    3301
XP_005248275                                                           17    3301
XP_006710114                                                           17    3301
NP_001073291                                                           17    4312
NP_000417                                                              17    4312
NP_001398                                                              17    4312
NP_919289                                                              17    4312
NP_937791                                                              17    4312
XP_005251508                                                           17    4312
XP_005251507                                                           17    4312
XP_005267039                                                           17    4312
XP_005267038                                                           17    4312
NP_056139                                                              16    5631
NP_000255                                                              16    5631
NP_001258966                                                           16    5631
NP_006141                                                              16    5631
NP_659428                                                              16    5631
XP_005261214                                                           16    5631
NP_751895                                                              16    7355
NP_004691                                                              16    7355
NP_116206                                                              16    7355
NP_006363                                                              16    7355
NP_001265578                                                           16    7355
NP_001095869                                                           16    7355
NP_001095868                                                           16    7355
NP_001095867                                                           16    7355
NP_005817                                                              16    7355
NP_001158001                                                           16    7355
NP_085046                                                              16    7355
NP_476518                                                              16    7355
NP_001001851                                                           16    7355
NP_995585                                                              16    7355
NP_001153147                                                           16    7355
XP_005259268                                                           16    7355
XP_005248694                                                           16    7355
XP_005248693                                                           16    7355
XP_005246331                                                           16    7355
XP_005246330                                                           16    7355
XP_005245771                                                           16    7355
XP_005245769                                                           16    7355
XP_005245770                                                           16    7355
XP_005245768                                                           16    7355
NP_001073938                                                           16    7355
NP_001158002                                                           16    7355
NP_001157999                                                           16    7355
NP_009065                                                              16    7355
NP_005804                                                              15    9605
NP_036211                                                              15    9605
NP_002733                                                              15    9605
NP_001073351                                                           15    9605
NP_001073350                                                           15    9605
NP_001073349                                                           15    9605
NP_057541                                                              15    9605
NP_078950                                                              15    9605
XP_005258773                                                           15    9605
XP_005267916                                                           15    9605
XP_006715904                                                           15    9605
XP_006715903                                                           15    9605
XP_006712043                                                           15    9605
XP_006712042                                                           15    9605
XP_006712041                                                           15    9605
XP_005264295                                                           15    9605
XP_005264294                                                           15    9605
XP_006710963                                                           15    9605
XP_006710962                                                           15    9605
XP_006710046                                                           15    9605
NP_066971                                                              15    9605
>NP_361014
          Length = 707

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  VGSKRRQTG 9
          VGSKRR+TG
Sbjct: 8  VGSKRRRTG 16
>NP_001243998
          Length = 176

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  VGSKRRQTG 9
          VGSKRR+TG
Sbjct: 8  VGSKRRRTG 16
>NP_000771
          Length = 504

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VGSKRRQTG 9
          +G +RRQTG
Sbjct: 22 LGIRRRQTG 30
>XP_006723584
          Length = 641

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGSKRRQTG 9
           VG +RR TG
Sbjct: 331 VGHRRRHTG 339
>XP_006723583
          Length = 641

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGSKRRQTG 9
           VG +RR TG
Sbjct: 331 VGHRRRHTG 339
>XP_006723582
          Length = 641

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGSKRRQTG 9
           VG +RR TG
Sbjct: 331 VGHRRRHTG 339
>XP_005248275
          Length = 136

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VGSKRRQTG 9
           VG+KR+Q G
Sbjct: 127 VGNKRKQHG 135
>XP_006710114
          Length = 423

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGSKRRQTG 9
           VG +RR TG
Sbjct: 113 VGHRRRHTG 121
>NP_001073291
          Length = 3118

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KRRQTG 9
            KRRQTG
Sbjct: 2573 KRRQTG 2578
>NP_000417
          Length = 3122

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KRRQTG 9
            KRRQTG
Sbjct: 2577 KRRQTG 2582
>NP_001398
          Length = 3312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VGSKRRQTG 9
           +GS+ R+TG
Sbjct: 118 LGSRERETG 126
>NP_919289
          Length = 1368

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           GSK R TG
Sbjct: 410 GSKERSTG 417
>NP_937791
          Length = 756

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G KRRQ G
Sbjct: 749 GQKRRQRG 756
>XP_005251508
          Length = 1007

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GSKRRQTG 9
          GSK R TG
Sbjct: 49 GSKERSTG 56
>XP_005251507
          Length = 1079

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           GSK R TG
Sbjct: 121 GSKERSTG 128
>XP_005267039
          Length = 3206

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KRRQTG 9
            KRRQTG
Sbjct: 2661 KRRQTG 2666
>XP_005267038
          Length = 3210

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KRRQTG 9
            KRRQTG
Sbjct: 2665 KRRQTG 2670
>NP_056139
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GSKRRQ 7
          GSKRRQ
Sbjct: 34 GSKRRQ 39
>NP_000255
          Length = 1447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GSKRRQTG 9
          G +RR+TG
Sbjct: 30 GGRRRRTG 37
>NP_001258966
          Length = 601

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGSKRRQTG 9
           VGS+RR  G
Sbjct: 132 VGSRRRAKG 140
>NP_006141
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  GSKRRQTG 9
          GS+RR++G
Sbjct: 5  GSRRRRSG 12
>NP_659428
          Length = 669

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGSKRRQTG 9
           VGS+RR  G
Sbjct: 200 VGSRRRAKG 208
>XP_005261214
          Length = 530

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGSKRRQTG 9
           VGS+RR  G
Sbjct: 132 VGSRRRAKG 140
>NP_751895
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VGSKRRQTG 9
           +GS +R+TG
Sbjct: 388 MGSSQRRTG 396
>NP_004691
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VGSKRRQTG 9
           +GS +R+TG
Sbjct: 442 MGSSQRRTG 450
>NP_116206
          Length = 728

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VGSKRRQT 8
           VG+K RQT
Sbjct: 93  VGTKLRQT 100
>NP_006363
          Length = 623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 575 SKRRQT 580
>NP_001265578
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSKRRQTG 9
           G +RRQ+G
Sbjct: 304 GPRRRQSG 311
>NP_001095869
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 485 SKRRQT 490
>NP_001095868
          Length = 636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 586 SKRRQT 591
>NP_001095867
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 482 SKRRQT 487
>NP_005817
          Length = 633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 583 SKRRQT 588
>NP_001158001
          Length = 115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VGSKRRQTG 9
          +GS+RR  G
Sbjct: 3  LGSRRRSVG 11
>NP_085046
          Length = 942

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VGSKRRQT 8
           VG+K RQT
Sbjct: 307 VGTKLRQT 314
>NP_476518
          Length = 1136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSKRRQTG 9
           G+K R+TG
Sbjct: 515 GNKSRETG 522
>NP_001001851
          Length = 702

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VGSKRRQT 8
           VG+K RQT
Sbjct: 307 VGTKLRQT 314
>NP_995585
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSKRRQTG 9
           G+K R+TG
Sbjct: 515 GNKSRETG 522
>NP_001153147
          Length = 588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 540 SKRRQT 545
>XP_005259268
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VGSKRRQTG 9
          +GS+RR  G
Sbjct: 3  LGSRRRSVG 11
>XP_005248694
          Length = 623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 575 SKRRQT 580
>XP_005248693
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 477 SKRRQT 482
>XP_005246331
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSKRRQTG 9
           G+K R+TG
Sbjct: 316 GNKSRETG 323
>XP_005246330
          Length = 1205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSKRRQTG 9
           G+K R+TG
Sbjct: 515 GNKSRETG 522
>XP_005245771
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 444 SKRRQT 449
>XP_005245769
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 545 SKRRQT 550
>XP_005245770
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 545 SKRRQT 550
>XP_005245768
          Length = 633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SKRRQT 8
           SKRRQT
Sbjct: 583 SKRRQT 588
>NP_001073938
          Length = 603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGSKRRQTG 9
           VGS+RR  G
Sbjct: 213 VGSERRSGG 221
>NP_001158002
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VGSKRRQTG 9
          +GS+RR  G
Sbjct: 3  LGSRRRSVG 11
>NP_001157999
          Length = 123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VGSKRRQTG 9
          +GS+RR  G
Sbjct: 3  LGSRRRSVG 11
>NP_009065
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VGSKRRQTG 9
          +GS+RR  G
Sbjct: 3  LGSRRRSVG 11
>NP_005804
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 592 GGKHRKTG 599
>NP_036211
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SKRRQTG 9
          S+RR+TG
Sbjct: 7  SRRRRTG 13
>NP_002733
          Length = 912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 599 GGKHRKTG 606
>NP_001073351
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 410 GGKHRKTG 417
>NP_001073350
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 567 GGKHRKTG 574
>NP_001073349
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 567 GGKHRKTG 574
>NP_057541
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 567 GGKHRKTG 574
>NP_078950
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VGSKRRQTG 9
           +GS+RR  G
Sbjct: 118 IGSERRPKG 126
>XP_005258773
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 410 GGKHRKTG 417
>XP_005267916
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 607 GGKHRKTG 614
>XP_006715904
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KRRQTG 9
           K+RQTG
Sbjct: 132 KKRQTG 137
>XP_006715903
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KRRQTG 9
           K+RQTG
Sbjct: 132 KKRQTG 137
>XP_006712043
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 333 GGKHRKTG 340
>XP_006712042
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 419 GGKHRKTG 426
>XP_006712041
          Length = 717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 419 GGKHRKTG 426
>XP_005264295
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 488 GGKHRKTG 495
>XP_005264294
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GSKRRQTG 9
           G K R+TG
Sbjct: 592 GGKHRKTG 599
>XP_006710963
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VGSKRRQTG 9
           +GS+RR  G
Sbjct: 118 IGSERRPKG 126
>XP_006710962
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VGSKRRQTG 9
           +GS+RR  G
Sbjct: 118 IGSERRPKG 126
>XP_006710046
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSKRRQTG 9
           GS+RR+ G
Sbjct: 376 GSRRRRCG 383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSKRRQTG 9
           GS+RR+ G
Sbjct: 397 GSRRRRCG 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GSKRRQTG 9
           GS+RR+ G
Sbjct: 411 GSRRRRCG 418
>NP_066971
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KRRQTG 9
           K+RQTG
Sbjct: 197 KKRQTG 202
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.128    0.345 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 637,649
Number of extensions: 1547
Number of successful extensions: 74
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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