Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              17    2528
NP_001242953                                                           17    2528
NP_067049                                                              17    2528
NP_001242955                                                           17    2528
NP_001242954                                                           17    2528
XP_006717997                                                           17    2528
XP_005270071                                                           17    2528
NP_109593                                                              17    3301
NP_109595                                                              17    3301
NP_109596                                                              17    3301
NP_109592                                                              17    3301
NP_109594                                                              17    3301
NP_002839                                                              17    3301
NP_001138498                                                           16    5631
NP_078966                                                              16    5631
NP_002111                                                              16    7355
NP_055573                                                              15    9605
NP_001070949                                                           15    9605
NP_001070948                                                           15    9605
NP_001070947                                                           15    9605
NP_001070938                                                           15    9605
NP_001070940                                                           15    9605
NP_001070950                                                           15    9605
NP_001070939                                                           15    9605
NP_005113                                                              15    9605
NP_055324                                                              15    9605
XP_006724285                                                           15    9605
XP_005271603                                                           15    9605
XP_005271602                                                           15    9605
XP_006711759                                                           15    9605
XP_005245754                                                           15    9605
XP_005245751                                                           15    9605
XP_005245750                                                           15    9605
NP_055839                                                              15    9605
NP_004751                                                              15    9605
>NP_055365
          Length = 1032

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VGLVSELRA 9
           V LVSELRA
Sbjct: 277 VDLVSELRA 285
>NP_001242953
          Length = 714

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GLVSELRA 9
           GLV+ELRA
Sbjct: 617 GLVTELRA 624
>NP_067049
          Length = 698

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GLVSELRA 9
           GLV+ELRA
Sbjct: 601 GLVTELRA 608
>NP_001242955
          Length = 608

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GLVSELRA 9
           GLV+ELRA
Sbjct: 511 GLVTELRA 518
>NP_001242954
          Length = 704

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GLVSELRA 9
           GLV+ELRA
Sbjct: 607 GLVTELRA 614
>XP_006717997
          Length = 608

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GLVSELRA 9
           GLV+ELRA
Sbjct: 511 GLVTELRA 518
>XP_005270071
          Length = 624

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   GLVSELRA 9
           GLV+ELRA
Sbjct: 527 GLVTELRA 534
>NP_109593
          Length = 377

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GLVSE+R+
Sbjct: 326 LGLVSEMRS 334
>NP_109595
          Length = 377

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GLVSE+R+
Sbjct: 326 LGLVSEMRS 334
>NP_109596
          Length = 405

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GLVSE+R+
Sbjct: 354 LGLVSEMRS 362
>NP_109592
          Length = 1216

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    VGLVSELRA 9
            +GLVSE+R+
Sbjct: 1165 LGLVSEMRS 1173
>NP_109594
          Length = 405

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GLVSE+R+
Sbjct: 354 LGLVSEMRS 362
>NP_002839
          Length = 1188

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    VGLVSELRA 9
            +GLVSE+R+
Sbjct: 1137 LGLVSEMRS 1145
>NP_001138498
          Length = 2299

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    GLVSELRA 9
            GLV+ELR+
Sbjct: 2230 GLVAELRS 2237
>NP_078966
          Length = 14507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LVSELRA 9
           LVSELRA
Sbjct: 916 LVSELRA 922
>NP_002111
          Length = 273

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VGLVSELRA 9
           VG+V +LRA
Sbjct: 241 VGIVIQLRA 249
>NP_055573
          Length = 992

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GLVSELR 8
           GLV ELR
Sbjct: 137 GLVQELR 143
>NP_001070949
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 279 LGLLAELRS 287
>NP_001070948
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 317 LGLLAELRS 325
>NP_001070947
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 284 LGLLAELRS 292
>NP_001070938
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 245 LGLLAELRS 253
>NP_001070940
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 289 LGLLAELRS 297
>NP_001070950
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 322 LGLLAELRS 330
>NP_001070939
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 274 LGLLAELRS 282
>NP_005113
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 313 LGLLAELRS 321
>NP_055324
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GLVSELR 8
          GL+SEL+
Sbjct: 8  GLISELK 14
>XP_006724285
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GLVSELR 8
          GL+SEL+
Sbjct: 8  GLISELK 14
>XP_005271603
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GLVSELR 8
           GLV ELR
Sbjct: 137 GLVQELR 143
>XP_005271602
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GLVSELR 8
           GLV ELR
Sbjct: 137 GLVQELR 143
>XP_006711759
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 155 LGLLAELRS 163
>XP_005245754
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 318 LGLLAELRS 326
>XP_005245751
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 389 LGLLAELRS 397
>XP_005245750
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGLVSELRA 9
           +GL++ELR+
Sbjct: 394 LGLLAELRS 402
>NP_055839
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VGLVSELR 8
           VGLV +LR
Sbjct: 720 VGLVRDLR 727
>NP_004751
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  GLVSELRA 9
          GL++E+RA
Sbjct: 41 GLLTEIRA 48
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.138    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 386,189
Number of extensions: 519
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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