Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              20     390
NP_005913                                                              20     390
XP_005267046                                                           20     390
XP_005267045                                                           20     390
NP_077719                                                              17    4312
NP_001030025                                                           17    4312
NP_000319                                                              17    4312
NP_001036064                                                           17    4312
NP_005226                                                              17    4312
NP_060647                                                              17    4312
XP_005272690                                                           17    4312
XP_006724601                                                           17    4312
XP_006714086                                                           17    4312
XP_006714085                                                           17    4312
XP_006714084                                                           17    4312
XP_005246434                                                           17    4312
XP_005246433                                                           17    4312
XP_005246432                                                           17    4312
XP_006712427                                                           17    4312
XP_005270959                                                           17    4312
XP_005270958                                                           17    4312
XP_006710730                                                           17    4312
NP_057287                                                              16    5631
NP_077747                                                              16    5631
NP_001035723                                                           16    5631
XP_006716351                                                           16    5631
XP_005250066                                                           16    5631
XP_005250064                                                           16    5631
XP_005250063                                                           16    5631
XP_005250062                                                           16    5631
XP_005250061                                                           16    5631
XP_006716084                                                           16    5631
XP_005250060                                                           16    5631
XP_005250059                                                           16    5631
NP_001743                                                              16    7355
NP_079071                                                              16    7355
NP_060310                                                              16    7355
NP_001231509                                                           15    9605
NP_003487                                                              15    9605
NP_002301                                                              15    9605
NP_001121143                                                           15    9605
NP_006435                                                              15    9605
NP_001036016                                                           15    9605
NP_001252531                                                           15    9605
NP_115518                                                              15    9605
NP_004669                                                              15    9605
NP_001036015                                                           15    9605
XP_006722394                                                           15    9605
XP_005258167                                                           15    9605
XP_006722393                                                           15    9605
XP_006722392                                                           15    9605
XP_006722391                                                           15    9605
XP_006722390                                                           15    9605
XP_005258166                                                           15    9605
XP_006722389                                                           15    9605
XP_005258165                                                           15    9605
XP_005258164                                                           15    9605
XP_006716996                                                           15    9605
NP_001002761                                                           15    9605
NP_001002760                                                           15    9605
>NP_006715
          Length = 1558

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +GIKNLSDI
Sbjct: 414 LGIKNLSDI 422
>NP_005913
          Length = 1608

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +GIKNLSDI
Sbjct: 414 LGIKNLSDI 422
>XP_005267046
          Length = 1554

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +GIKNLSDI
Sbjct: 414 LGIKNLSDI 422
>XP_005267045
          Length = 1604

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +GIKNLSDI
Sbjct: 414 LGIKNLSDI 422
>NP_077719
          Length = 2471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    VGIKNLS 7
            VG+KNLS
Sbjct: 1735 VGLKNLS 1741
>NP_001030025
          Length = 1152

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +G+KN+S++
Sbjct: 172 IGLKNVSNV 180
>NP_000319
          Length = 815

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +G+KN+S++
Sbjct: 172 IGLKNVSNV 180
>NP_001036064
          Length = 1292

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +G+KNL++I
Sbjct: 134 LGLKNLTEI 142
>NP_005226
          Length = 1308

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +G+KNL++I
Sbjct: 134 LGLKNLTEI 142
>NP_060647
          Length = 1770

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VGIKNLSDI 9
            VG+KN +DI
Sbjct: 1226 VGLKNNNDI 1234
>XP_005272690
          Length = 704

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +G+KN+S++
Sbjct: 172 IGLKNVSNV 180
>XP_006724601
          Length = 1020

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +G+KN+S++
Sbjct: 172 IGLKNVSNV 180
>XP_006714086
          Length = 1690

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VGIKNLSDI 9
            VG+KN +DI
Sbjct: 1146 VGLKNNNDI 1154
>XP_006714085
          Length = 1690

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VGIKNLSDI 9
            VG+KN +DI
Sbjct: 1146 VGLKNNNDI 1154
>XP_006714084
          Length = 1753

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VGIKNLSDI 9
            VG+KN +DI
Sbjct: 1226 VGLKNNNDI 1234
>XP_005246434
          Length = 1282

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +G+KNL++I
Sbjct: 134 LGLKNLTEI 142
>XP_005246433
          Length = 1298

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +G+KNL++I
Sbjct: 134 LGLKNLTEI 142
>XP_005246432
          Length = 1307

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +G+KNL++I
Sbjct: 134 LGLKNLTEI 142
>XP_006712427
          Length = 1323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VGIKNLSDI 9
           +G+KNL++I
Sbjct: 134 LGLKNLTEI 142
>XP_005270959
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    VGIKNLS 7
            VG+KNLS
Sbjct: 1696 VGLKNLS 1702
>XP_005270958
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    VGIKNLS 7
            VG+KNLS
Sbjct: 1696 VGLKNLS 1702
>XP_006710730
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    VGIKNLS 7
            VG+KNLS
Sbjct: 1696 VGLKNLS 1702
>NP_057287
          Length = 569

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           VGI +LSDI
Sbjct: 542 VGIISLSDI 550
>NP_077747
          Length = 328

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           VGI +LSDI
Sbjct: 301 VGIISLSDI 309
>NP_001035723
          Length = 525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           VGI +LSDI
Sbjct: 498 VGIISLSDI 506
>XP_006716351
          Length = 865

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GIKNLSDI 9
           GI+N SDI
Sbjct: 298 GIENASDI 305
>XP_005250066
          Length = 358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           VGI +LSDI
Sbjct: 281 VGIISLSDI 289
>XP_005250064
          Length = 444

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           VGI +LSDI
Sbjct: 417 VGIISLSDI 425
>XP_005250063
          Length = 495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           VGI +LSDI
Sbjct: 418 VGIISLSDI 426
>XP_005250062
          Length = 568

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           VGI +LSDI
Sbjct: 541 VGIISLSDI 549
>XP_005250061
          Length = 575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           VGI +LSDI
Sbjct: 498 VGIISLSDI 506
>XP_006716084
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           VGI +LSDI
Sbjct: 538 VGIISLSDI 546
>XP_005250060
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           VGI +LSDI
Sbjct: 541 VGIISLSDI 549
>XP_005250059
          Length = 619

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           VGI +LSDI
Sbjct: 542 VGIISLSDI 550
>NP_001743
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GIKNLS 7
           GIKNLS
Sbjct: 241 GIKNLS 246
>NP_079071
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IKNLSDI 9
           +KN+SDI
Sbjct: 130 LKNISDI 136
>NP_060310
          Length = 251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  KNLSDI 9
          KNLSDI
Sbjct: 67 KNLSDI 72
>NP_001231509
          Length = 3859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    VGIKNLSDI 9
            VG++N+S++
Sbjct: 3380 VGLENVSNV 3388
>NP_003487
          Length = 3830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1    VGIKNLSDI 9
            VG++N+S++
Sbjct: 3351 VGLENVSNV 3359
>NP_002301
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           + +KN++DI
Sbjct: 783 IKVKNITDI 791
>NP_001121143
          Length = 1097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VGIKNLSDI 9
           + +KN++DI
Sbjct: 783 IKVKNITDI 791
>NP_006435
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VGIKNLSDI 9
          +GI NLS +
Sbjct: 49 LGISNLSQV 57
>NP_001036016
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VGIKNLSDI 9
          +GI NLS +
Sbjct: 49 LGISNLSQV 57
>NP_001252531
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VGIKNLSDI 9
          +GI NLS +
Sbjct: 49 LGISNLSQV 57
>NP_115518
          Length = 2537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GIKNLSD 8
            G+K LSD
Sbjct: 1888 GVKKLSD 1894
>NP_004669
          Length = 106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  KNLSDI 9
          KNLSD+
Sbjct: 40 KNLSDV 45
>NP_001036015
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VGIKNLSDI 9
          +GI NLS +
Sbjct: 49 LGISNLSQV 57
>XP_006722394
          Length = 1845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GIKNLSD 8
            G+K LSD
Sbjct: 1195 GVKKLSD 1201
>XP_005258167
          Length = 1856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GIKNLSD 8
            G+K LSD
Sbjct: 1206 GVKKLSD 1212
>XP_006722393
          Length = 2199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GIKNLSD 8
            G+K LSD
Sbjct: 1549 GVKKLSD 1555
>XP_006722392
          Length = 2444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GIKNLSD 8
            G+K LSD
Sbjct: 1794 GVKKLSD 1800
>XP_006722391
          Length = 2448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GIKNLSD 8
            G+K LSD
Sbjct: 1798 GVKKLSD 1804
>XP_006722390
          Length = 2467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GIKNLSD 8
            G+K LSD
Sbjct: 1818 GVKKLSD 1824
>XP_005258166
          Length = 2468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GIKNLSD 8
            G+K LSD
Sbjct: 1818 GVKKLSD 1824
>XP_006722389
          Length = 2506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GIKNLSD 8
            G+K LSD
Sbjct: 1888 GVKKLSD 1894
>XP_005258165
          Length = 2534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GIKNLSD 8
            G+K LSD
Sbjct: 1884 GVKKLSD 1890
>XP_005258164
          Length = 2538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GIKNLSD 8
            G+K LSD
Sbjct: 1888 GVKKLSD 1894
>XP_006716996
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VGIKNLSDI 9
          +GI NLS +
Sbjct: 49 LGISNLSQV 57
>NP_001002761
          Length = 106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  KNLSDI 9
          KNLSD+
Sbjct: 40 KNLSDV 45
>NP_001002760
          Length = 106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  KNLSDI 9
          KNLSD+
Sbjct: 40 KNLSDV 45
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.144    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 443,885
Number of extensions: 811
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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