Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001277144                                                           20     509
NP_001277143                                                           20     509
NP_001077383                                                           20     509
NP_001320                                                              20     509
NP_073713                                                              20     509
XP_005269629                                                           20     509
XP_005269628                                                           20     509
XP_005269627                                                           20     509
XP_005269626                                                           20     509
XP_006717706                                                           20     509
XP_005269625                                                           20     509
XP_005269624                                                           20     509
XP_006717705                                                           20     509
XP_005269622                                                           20     509
XP_005269621                                                           20     509
XP_006717704                                                           20     509
XP_005269619                                                           20     509
XP_005269618                                                           20     509
NP_001319                                                              18    1135
NP_001012632                                                           18    1135
XP_005272320                                                           18    1135
XP_005272319                                                           18    1135
XP_005272318                                                           18    1135
NP_005597                                                              17    4312
NP_001008530                                                           17    4312
XP_005267920                                                           17    4312
XP_005267919                                                           17    4312
NP_005236                                                              16    5631
NP_563615                                                              16    5631
NP_071417                                                              16    5631
XP_006714202                                                           16    5631
XP_005262892                                                           16    5631
XP_005262891                                                           16    5631
NP_003213                                                              16    7355
NP_878314                                                              16    7355
NP_665735                                                              16    7355
NP_665734                                                              16    7355
NP_665707                                                              16    7355
NP_055160                                                              16    7355
NP_001247440                                                           16    7355
NP_064696                                                              16    7355
NP_733751                                                              15    9605
XP_006716142                                                           15    9605
XP_005250088                                                           15    9605
XP_006716141                                                           15    9605
XP_005250085                                                           15    9605
XP_006716140                                                           15    9605
XP_005250084                                                           15    9605
XP_005250083                                                           15    9605
XP_005250082                                                           15    9605
>NP_001277144
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>NP_001277143
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>NP_001077383
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>NP_001320
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>NP_073713
          Length = 985

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VGAMMNHTI 9
           VGAMM HTI
Sbjct: 617 VGAMMYHTI 625
>XP_005269629
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_005269628
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_005269627
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_005269626
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_006717706
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_005269625
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_005269624
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_006717705
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_005269622
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_005269621
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_006717704
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_005269619
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>XP_005269618
          Length = 445

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGAMM HTI
Sbjct: 77 VGAMMYHTI 85
>NP_001319
          Length = 440

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGA+M HTI
Sbjct: 71 VGALMYHTI 79
>NP_001012632
          Length = 429

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGA+M HTI
Sbjct: 60 VGALMYHTI 68
>XP_005272320
          Length = 430

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGA+M HTI
Sbjct: 60 VGALMYHTI 68
>XP_005272319
          Length = 430

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGA+M HTI
Sbjct: 60 VGALMYHTI 68
>XP_005272318
          Length = 441

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  VGAMMNHTI 9
          VGA+M HTI
Sbjct: 71 VGALMYHTI 79
>NP_005597
          Length = 433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAMMNH 7
           G+MMNH
Sbjct: 192 GSMMNH 197
>NP_001008530
          Length = 433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAMMNH 7
           G+MMNH
Sbjct: 192 GSMMNH 197
>XP_005267920
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAMMNH 7
           G+MMNH
Sbjct: 192 GSMMNH 197
>XP_005267919
          Length = 376

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAMMNH 7
           G+MMNH
Sbjct: 192 GSMMNH 197
>NP_005236
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MMNHTI 9
            M+NHTI
Sbjct: 3638 MLNHTI 3643
>NP_563615
          Length = 775

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VGAMMNHTI 9
           +G  MNH+I
Sbjct: 150 LGLQMNHSI 158
>NP_071417
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GAMMNHT 8
           GA+ NHT
Sbjct: 326 GALKNHT 332
>XP_006714202
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MMNHTI 9
            M+NHTI
Sbjct: 3638 MLNHTI 3643
>XP_005262892
          Length = 4600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MMNHTI 9
            M+NHTI
Sbjct: 3638 MLNHTI 3643
>XP_005262891
          Length = 4600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    MMNHTI 9
            M+NHTI
Sbjct: 3638 MLNHTI 3643
>NP_003213
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VGAMMNHT 8
           VGA+MN T
Sbjct: 214 VGAVMNPT 221
>NP_878314
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GAMMNHTI 9
           GAM+ H+I
Sbjct: 223 GAMVRHSI 230
>NP_665735
          Length = 155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGAMMNHTI 9
           VGA + HTI
Sbjct: 111 VGARIYHTI 119
>NP_665734
          Length = 155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGAMMNHTI 9
           VGA + HTI
Sbjct: 111 VGARIYHTI 119
>NP_665707
          Length = 155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGAMMNHTI 9
           VGA + HTI
Sbjct: 111 VGARIYHTI 119
>NP_055160
          Length = 2279

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VGAMMNHT 8
            VGA+ +HT
Sbjct: 2266 VGAIQDHT 2273
>NP_001247440
          Length = 155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGAMMNHTI 9
           VGA + HTI
Sbjct: 111 VGARIYHTI 119
>NP_064696
          Length = 155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGAMMNHTI 9
           VGA + HTI
Sbjct: 111 VGARIYHTI 119
>NP_733751
          Length = 4911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VGAMMNHTI 9
            VG+++ HTI
Sbjct: 4550 VGSLIFHTI 4558
>XP_006716142
          Length = 4927

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VGAMMNHTI 9
            VG+++ HTI
Sbjct: 4566 VGSLIFHTI 4574
>XP_005250088
          Length = 4928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VGAMMNHTI 9
            VG+++ HTI
Sbjct: 4567 VGSLIFHTI 4575
>XP_006716141
          Length = 4959

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VGAMMNHTI 9
            VG+++ HTI
Sbjct: 4598 VGSLIFHTI 4606
>XP_005250085
          Length = 4979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VGAMMNHTI 9
            VG+++ HTI
Sbjct: 4622 VGSLIFHTI 4630
>XP_006716140
          Length = 4982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VGAMMNHTI 9
            VG+++ HTI
Sbjct: 4621 VGSLIFHTI 4629
>XP_005250084
          Length = 4982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VGAMMNHTI 9
            VG+++ HTI
Sbjct: 4621 VGSLIFHTI 4629
>XP_005250083
          Length = 4982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VGAMMNHTI 9
            VG+++ HTI
Sbjct: 4621 VGSLIFHTI 4629
>XP_005250082
          Length = 4983

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VGAMMNHTI 9
            VG+++ HTI
Sbjct: 4622 VGSLIFHTI 4630
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.130    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 455,736
Number of extensions: 566
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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