Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              18    1935
XP_006716142                                                           18    1935
XP_005250088                                                           18    1935
XP_006716141                                                           18    1935
XP_005250085                                                           18    1935
XP_006716140                                                           18    1935
XP_005250084                                                           18    1935
XP_005250083                                                           18    1935
XP_005250082                                                           18    1935
NP_776297                                                              16    5631
NP_001230301                                                           16    5631
NP_001820                                                              16    5631
NP_001230303                                                           16    5631
XP_005262783                                                           16    5631
XP_006726466                                                           16    7355
XP_006712969                                                           16    7355
XP_005275995                                                           16    7355
NP_001073883                                                           15    9605
NP_005537                                                              15    9605
NP_001243000                                                           15    9605
NP_036329                                                              15    9605
NP_001135741                                                           15    9605
NP_000812                                                              15    9605
NP_001273542                                                           15    9605
NP_067639                                                              15    9605
NP_037511                                                              15    9605
NP_653221                                                              15    9605
NP_073602                                                              15    9605
NP_001152763                                                           15    9605
NP_001243316                                                           15    9605
NP_001243315                                                           15    9605
NP_001243314                                                           15    9605
NP_001138490                                                           15    9605
XP_005257614                                                           15    9605
XP_005257603                                                           15    9605
XP_006722058                                                           15    9605
XP_005257602                                                           15    9605
XP_005267748                                                           15    9605
XP_006718884                                                           15    9605
XP_006718882                                                           15    9605
XP_006718879                                                           15    9605
XP_006717146                                                           15    9605
XP_005266132                                                           15    9605
XP_006717095                                                           15    9605
XP_006717094                                                           15    9605
XP_005251923                                                           15    9605
XP_005264316                                                           15    9605
XP_005270516                                                           15    9605
NP_114062                                                              15    9605
NP_061734                                                              15    9605
>NP_733751
          Length = 4911

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VELALRRDL 9
            VELALRR L
Sbjct: 4450 VELALRRGL 4458
>XP_006716142
          Length = 4927

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VELALRRDL 9
            VELALRR L
Sbjct: 4466 VELALRRGL 4474
>XP_005250088
          Length = 4928

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VELALRRDL 9
            VELALRR L
Sbjct: 4467 VELALRRGL 4475
>XP_006716141
          Length = 4959

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VELALRRDL 9
            VELALRR L
Sbjct: 4498 VELALRRGL 4506
>XP_005250085
          Length = 4979

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VELALRRDL 9
            VELALRR L
Sbjct: 4522 VELALRRGL 4530
>XP_006716140
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VELALRRDL 9
            VELALRR L
Sbjct: 4521 VELALRRGL 4529
>XP_005250084
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VELALRRDL 9
            VELALRR L
Sbjct: 4521 VELALRRGL 4529
>XP_005250083
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VELALRRDL 9
            VELALRR L
Sbjct: 4521 VELALRRGL 4529
>XP_005250082
          Length = 4983

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VELALRRDL 9
            VELALRR L
Sbjct: 4522 VELALRRGL 4530
>NP_776297
          Length = 866

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VELALRRDL 9
           V  ALRRDL
Sbjct: 704 VGFALRRDL 712
>NP_001230301
          Length = 791

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VELALRRDL 9
           V  ALRRDL
Sbjct: 677 VGFALRRDL 685
>NP_001820
          Length = 818

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VELALRRDL 9
           V  ALRRDL
Sbjct: 704 VGFALRRDL 712
>NP_001230303
          Length = 791

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VELALRRDL 9
           V  ALRRDL
Sbjct: 677 VGFALRRDL 685
>XP_005262783
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VELALRRDL 9
           V  ALRRDL
Sbjct: 677 VGFALRRDL 685
>XP_006726466
          Length = 1310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ELALRRD 8
           ELALRR+
Sbjct: 130 ELALRRE 136
>XP_006712969
          Length = 1310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ELALRRD 8
           ELALRR+
Sbjct: 130 ELALRRE 136
>XP_005275995
          Length = 488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ELALRRD 8
           ELALRR+
Sbjct: 130 ELALRRE 136
>NP_001073883
          Length = 2028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ALRRDL 9
           ALRRDL
Sbjct: 798 ALRRDL 803
>NP_005537
          Length = 620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ELALRRD 8
           ELALRR+
Sbjct: 189 ELALRRN 195
>NP_001243000
          Length = 5207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LALRRDL 9
            LAL+RDL
Sbjct: 4788 LALQRDL 4794
>NP_036329
          Length = 1069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ELALRRDL 9
           ++ALR+DL
Sbjct: 867 KIALRKDL 874
>NP_001135741
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ELALRRDL 9
           ELAL +DL
Sbjct: 551 ELALEQDL 558
>NP_000812
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ELALRRDL 9
           ELAL +DL
Sbjct: 608 ELALEQDL 615
>NP_001273542
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VELALRR 7
           +ELALRR
Sbjct: 971 LELALRR 977
>NP_067639
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1 VELALRR 7
         +ELALRR
Sbjct: 1 MELALRR 7
>NP_037511
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ALRRDL 9
           ALRRDL
Sbjct: 144 ALRRDL 149
>NP_653221
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VELALRRDL 9
           +ELA+ RD+
Sbjct: 157 LELAVNRDI 165
>NP_073602
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VELALRR 7
           +ELALRR
Sbjct: 952 LELALRR 958
>NP_001152763
          Length = 981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VELALRR 7
           +ELALRR
Sbjct: 866 LELALRR 872
>NP_001243316
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VELALRRDL 9
           +ELA+ RD+
Sbjct: 157 LELAVNRDI 165
>NP_001243315
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VELALRRDL 9
           +ELA+ RD+
Sbjct: 157 LELAVNRDI 165
>NP_001243314
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VELALRRDL 9
           +ELA+ RD+
Sbjct: 157 LELAVNRDI 165
>NP_001138490
          Length = 210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LALRRD 8
          LALRRD
Sbjct: 45 LALRRD 50
>XP_005257614
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1 VELALRR 7
         +ELALRR
Sbjct: 1 MELALRR 7
>XP_005257603
          Length = 5256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LALRRDL 9
            LAL+RDL
Sbjct: 4837 LALQRDL 4843
>XP_006722058
          Length = 5256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LALRRDL 9
            LAL+RDL
Sbjct: 4837 LALQRDL 4843
>XP_005257602
          Length = 5256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LALRRDL 9
            LAL+RDL
Sbjct: 4837 LALQRDL 4843
>XP_005267748
          Length = 1535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ALRRDL 9
           ALRRDL
Sbjct: 798 ALRRDL 803
>XP_006718884
          Length = 267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LALRRD 8
          LALRRD
Sbjct: 45 LALRRD 50
>XP_006718882
          Length = 182

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LALRRD 8
          LALRRD
Sbjct: 45 LALRRD 50
>XP_006718879
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LALRRD 8
          LALRRD
Sbjct: 45 LALRRD 50
>XP_006717146
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ALRRDL 9
           ALRRDL
Sbjct: 144 ALRRDL 149
>XP_005266132
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ALRRDL 9
           ALRRDL
Sbjct: 144 ALRRDL 149
>XP_006717095
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ELALRRDL 9
           ++ALR+DL
Sbjct: 698 KIALRKDL 705
>XP_006717094
          Length = 1069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ELALRRDL 9
           ++ALR+DL
Sbjct: 867 KIALRKDL 874
>XP_005251923
          Length = 1069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ELALRRDL 9
           ++ALR+DL
Sbjct: 867 KIALRKDL 874
>XP_005264316
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ELALRRDL 9
           ELAL +DL
Sbjct: 608 ELALEQDL 615
>XP_005270516
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VELALRRDL 9
           +ELA+ RD+
Sbjct: 157 LELAVNRDI 165
>NP_114062
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VELALRRDL 9
           VEL LR+ L
Sbjct: 192 VELVLRKSL 200
>NP_061734
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VELALRRDL 9
           VEL LR+ L
Sbjct: 192 VELVLRKSL 200
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.150    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 381,936
Number of extensions: 562
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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