Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results 
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done




                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              19     665
NP_001166902                                                           17    4312
NP_056126                                                              17    4312
NP_001166879                                                           17    4312
NP_001001330                                                           17    4312
XP_005246484                                                           17    4312
XP_005246482                                                           17    4312
XP_005246481                                                           17    4312
XP_006712450                                                           17    4312
XP_005246480                                                           17    4312
XP_006712449                                                           17    4312
XP_005246478                                                           17    4312
NP_002102                                                              16    5631
NP_071423                                                              16    5631
NP_060417                                                              16    5631
XP_005272100                                                           16    5631
NP_001195                                                              16    7355
NP_055654                                                              16    7355
NP_001159724                                                           16    7355
NP_006328                                                              16    7355
NP_001013679                                                           16    7355
NP_001265270                                                           16    7355
XP_005268630                                                           16    7355
XP_005268629                                                           16    7355
NP_001012300                                                           16    7355
NP_002323                                                              15    9605
NP_570843                                                              15    9605
NP_001128529                                                           15    9605
NP_005754                                                              15    9605
NP_085076                                                              15    9605
NP_001005417                                                           15    9605
NP_001032238                                                           15    9605
NP_689654                                                              15    9605
NP_003771                                                              15    9605
XP_006711080                                                           15    9605
XP_005271361                                                           15    9605
NP_808881                                                              15    9605



>NP_000312
          Length = 928

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           VEIGS RYK
Sbjct: 439 VEIGSQRYK 447





>NP_001166902
          Length = 1543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           VE G+LRY+
Sbjct: 663 VEPGALRYR 671





>NP_056126
          Length = 1896

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           VE G+LRY+
Sbjct: 663 VEPGALRYR 671





>NP_001166879
          Length = 1025

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           VE G+LRY+
Sbjct: 663 VEPGALRYR 671





>NP_001001330
          Length = 255

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VEIGSLRYK 9
           V  GSL+YK
Sbjct: 238 VRYGSLKYK 246





>XP_005246484
          Length = 1359

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           VE G+LRY+
Sbjct: 663 VEPGALRYR 671





>XP_005246482
          Length = 1724

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           VE G+LRY+
Sbjct: 663 VEPGALRYR 671





>XP_005246481
          Length = 1804

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           VE G+LRY+
Sbjct: 663 VEPGALRYR 671





>XP_006712450
          Length = 1816

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           VE G+LRY+
Sbjct: 663 VEPGALRYR 671





>XP_005246480
          Length = 1816

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           VE G+LRY+
Sbjct: 663 VEPGALRYR 671





>XP_006712449
          Length = 1908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           VE G+LRY+
Sbjct: 663 VEPGALRYR 671





>XP_005246478
          Length = 1908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           VE G+LRY+
Sbjct: 663 VEPGALRYR 671





>NP_002102
          Length = 3144

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EIGSLRYK 9
            E+GS+ YK
Sbjct: 2608 ELGSMSYK 2615





>NP_071423
          Length = 686

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIGSLRYK 9
           + GS+RYK
Sbjct: 311 KFGSIRYK 318





>NP_060417
          Length = 888

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           + IGSLR++
Sbjct: 795 ISIGSLRFQ 803





>XP_005272100
          Length = 658

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EIGSLRYK 9
           + GS+RYK
Sbjct: 311 KFGSIRYK 318





>NP_001195
          Length = 1038

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   EIGSLRY 8
           E+G++RY
Sbjct: 376 EVGTIRY 382





>NP_055654
          Length = 763

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GSLRYK 9
           GS+RYK
Sbjct: 605 GSIRYK 610





>NP_001159724
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GSLRYK 9
           GS+RYK
Sbjct: 547 GSIRYK 552





>NP_006328
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEIGSLRY 8
           VEI SLR+
Sbjct: 433 VEIASLRF 440





>NP_001013679
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VEIGSLRYK 9
          VE+G  RY+
Sbjct: 71 VELGLFRYR 79





>NP_001265270
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEIGSLRY 8
           VEI SLR+
Sbjct: 242 VEIASLRF 249





>XP_005268630
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEIGSLRY 8
           VEI SLR+
Sbjct: 344 VEIASLRF 351





>XP_005268629
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEIGSLRY 8
           VEI SLR+
Sbjct: 433 VEIASLRF 440





>NP_001012300
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEIGSLRY 8
           VEI SLR+
Sbjct: 446 VEIASLRF 453





>NP_002323
          Length = 4544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VEIGSLRYK 9
            VEIG+  YK
Sbjct: 4466 VEIGNPTYK 4474





>NP_570843
          Length = 581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IGSLRY 8
           +GSLRY
Sbjct: 100 LGSLRY 105





>NP_001128529
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IGSLRY 8
           +GSLRY
Sbjct: 106 LGSLRY 111





>NP_005754
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GSLRYK 9
           G+LRYK
Sbjct: 723 GTLRYK 728





>NP_085076
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGSLRYK 9
           IGS+RY+
Sbjct: 368 IGSVRYQ 374





>NP_001005417
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGSLRYK 9
           IGS+RY+
Sbjct: 339 IGSVRYQ 345





>NP_001032238
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GSLRYK 9
           G+LRYK
Sbjct: 263 GTLRYK 268





>NP_689654
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EIGSLR 7
           EIGSLR
Sbjct: 115 EIGSLR 120





>NP_003771
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGSLRYK 9
           IGS+RY+
Sbjct: 339 IGSVRYQ 345





>XP_006711080
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGSLRYK 9
           IGS+RY+
Sbjct: 339 IGSVRYQ 345





>XP_005271361
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IGSLRYK 9
           IGS+RY+
Sbjct: 339 IGSVRYQ 345





>NP_808881
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VEIGSLRYK 9
           ++IG ++YK
Sbjct: 148 LQIGDVKYK 156





  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.143    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 464,050
Number of extensions: 811
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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