Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1935
XP_005262424                                                           18    1935
NP_001093321                                                           17    2528
NP_001038945                                                           17    2528
NP_071900                                                              16    5631
XP_006714967                                                           16    5631
XP_006714966                                                           16    5631
XP_006714964                                                           16    5631
XP_005266016                                                           16    5631
NP_001273988                                                           16    7355
NP_055867                                                              16    7355
NP_000370                                                              16    7355
NP_055093                                                              16    7355
NP_001153566                                                           16    7355
NP_060943                                                              16    7355
NP_001271203                                                           16    7355
NP_065811                                                              16    7355
NP_877497                                                              16    7355
XP_006723005                                                           16    7355
XP_005269612                                                           16    7355
XP_006715736                                                           16    7355
XP_006715735                                                           16    7355
XP_005249722                                                           16    7355
XP_006715734                                                           16    7355
XP_006715733                                                           16    7355
XP_006714203                                                           16    7355
XP_006712712                                                           16    7355
XP_006712711                                                           16    7355
XP_006712710                                                           16    7355
XP_006712709                                                           16    7355
NP_001269316                                                           15    9605
NP_005887                                                              15    9605
NP_001269315                                                           15    9605
NP_056153                                                              15    9605
XP_006723795                                                           15    9605
XP_006723794                                                           15    9605
XP_006723793                                                           15    9605
XP_006723792                                                           15    9605
XP_006723791                                                           15    9605
XP_006723790                                                           15    9605
>NP_722576
          Length = 3080

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VEETSTNAL 9
            VEETST AL
Sbjct: 1177 VEETSTYAL 1185
>XP_005262424
          Length = 2875

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VEETSTNAL 9
           VEETST AL
Sbjct: 972 VEETSTYAL 980
>NP_001093321
          Length = 474

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ETSTNAL 9
           ETSTNAL
Sbjct: 388 ETSTNAL 394
>NP_001038945
          Length = 474

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ETSTNAL 9
           ETSTNAL
Sbjct: 388 ETSTNAL 394
>NP_071900
          Length = 2696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EETSTNA 8
           EET TNA
Sbjct: 185 EETQTNA 191
>XP_006714967
          Length = 1327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EETSTNA 8
           EET TNA
Sbjct: 185 EETQTNA 191
>XP_006714966
          Length = 1499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EETSTNA 8
           EET TNA
Sbjct: 185 EETQTNA 191
>XP_006714964
          Length = 2696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EETSTNA 8
           EET TNA
Sbjct: 185 EETQTNA 191
>XP_005266016
          Length = 2696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EETSTNA 8
           EET TNA
Sbjct: 185 EETQTNA 191
>NP_001273988
          Length = 1572

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1563 VEETSTFGL 1571
>NP_055867
          Length = 1606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1597 VEETSTFGL 1605
>NP_000370
          Length = 1333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            + ETSTN +
Sbjct: 1064 ISETSTNTV 1072
>NP_055093
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEETSTNAL 9
           ++ETS NAL
Sbjct: 125 LKETSENAL 133
>NP_001153566
          Length = 117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VEETSTNAL 9
          VEE  TNA+
Sbjct: 21 VEEEHTNAI 29
>NP_060943
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VEETSTNAL 9
          VEE  TNA+
Sbjct: 44 VEEEHTNAI 52
>NP_001271203
          Length = 780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ETSTNAL 9
           ETSTN L
Sbjct: 736 ETSTNCL 742
>NP_065811
          Length = 1572

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1563 VEETSTFGL 1571
>NP_877497
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ETSTNAL 9
           ETSTN L
Sbjct: 732 ETSTNCL 738
>XP_006723005
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VEETSTN 7
           VEE STN
Sbjct: 212 VEENSTN 218
>XP_005269612
          Length = 669

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ETSTNAL 9
           ETSTN L
Sbjct: 625 ETSTNCL 631
>XP_006715736
          Length = 1573

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1564 VEETSTFGL 1572
>XP_006715735
          Length = 1606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1597 VEETSTFGL 1605
>XP_005249722
          Length = 1607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1598 VEETSTFGL 1606
>XP_006715734
          Length = 1607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1598 VEETSTFGL 1606
>XP_006715733
          Length = 1608

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1599 VEETSTFGL 1607
>XP_006714203
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VEETSTNAL 9
           ++ETS NAL
Sbjct: 125 LKETSENAL 133
>XP_006712712
          Length = 1414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1405 VEETSTFGL 1413
>XP_006712711
          Length = 1448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1439 VEETSTFGL 1447
>XP_006712710
          Length = 1528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1519 VEETSTFGL 1527
>XP_006712709
          Length = 1579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VEETSTNAL 9
            VEETST  L
Sbjct: 1570 VEETSTFGL 1578
>NP_001269316
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EETSTNAL 9
           +ETSTN +
Sbjct: 323 QETSTNPI 330
>NP_005887
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EETSTNAL 9
           +ETSTN +
Sbjct: 323 QETSTNPI 330
>NP_001269315
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EETSTNAL 9
           +ETSTN +
Sbjct: 323 QETSTNPI 330
>NP_056153
          Length = 1541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VEETSTNA 8
           ++ETS+NA
Sbjct: 127 LDETSSNA 134
>XP_006723795
          Length = 1480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VEETSTNA 8
           ++ETS+NA
Sbjct: 117 LDETSSNA 124
>XP_006723794
          Length = 1490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VEETSTNA 8
           ++ETS+NA
Sbjct: 127 LDETSSNA 134
>XP_006723793
          Length = 1513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VEETSTNA 8
           ++ETS+NA
Sbjct: 99  LDETSSNA 106
>XP_006723792
          Length = 1513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VEETSTNA 8
           ++ETS+NA
Sbjct: 99  LDETSSNA 106
>XP_006723791
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VEETSTNA 8
           ++ETS+NA
Sbjct: 117 LDETSSNA 124
>XP_006723790
          Length = 1540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VEETSTNA 8
           ++ETS+NA
Sbjct: 126 LDETSSNA 133
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.284    0.102    0.226 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 441,524
Number of extensions: 467
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

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