Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              20     509
XP_005273257                                                           20     509
NP_004466                                                              18    1935
NP_689835                                                              18    1935
NP_075463                                                              18    1935
XP_005258009                                                           18    1935
XP_006719812                                                           18    1935
XP_005248505                                                           18    1935
NP_542165                                                              17    3301
NP_004631                                                              17    3301
NP_036307                                                              17    4312
NP_208385                                                              17    4312
XP_005252908                                                           17    4312
NP_612450                                                              16    5631
NP_056131                                                              16    5631
XP_005267542                                                           16    5631
XP_005267541                                                           16    5631
XP_005267544                                                           16    5631
XP_006715390                                                           16    5631
NP_001154819                                                           16    7355
NP_001154817                                                           16    7355
NP_060693                                                              16    7355
NP_001154818                                                           16    7355
NP_001154816                                                           16    7355
NP_001121371                                                           16    7355
NP_001269092                                                           16    7355
NP_001121370                                                           16    7355
NP_000075                                                              16    7355
NP_001821                                                              16    7355
NP_001243873                                                           16    7355
NP_079358                                                              16    7355
NP_002288                                                              16    7355
NP_001239546                                                           16    7355
XP_006721341                                                           16    7355
XP_006721340                                                           16    7355
XP_006715629                                                           16    7355
XP_005247569                                                           16    7355
XP_005247568                                                           16    7355
NP_078970                                                              16    7355
NP_057022                                                              16    7355
NP_203747                                                              15    9605
NP_001269058                                                           15    9605
NP_056382                                                              15    9605
NP_001035931                                                           15    9605
NP_001035930                                                           15    9605
NP_115997                                                              15    9605
NP_002769                                                              15    9605
NP_061169                                                              15    9605
XP_006726921                                                           15    9605
XP_006724404                                                           15    9605
XP_006724403                                                           15    9605
XP_005261845                                                           15    9605
XP_005261844                                                           15    9605
XP_005261843                                                           15    9605
XP_006722213                                                           15    9605
XP_005258117                                                           15    9605
XP_006722212                                                           15    9605
XP_005258116                                                           15    9605
XP_005258115                                                           15    9605
XP_005254096                                                           15    9605
XP_005254095                                                           15    9605
XP_005262765                                                           15    9605
XP_005262764                                                           15    9605
XP_006714135                                                           15    9605
XP_005262763                                                           15    9605
>NP_064450
          Length = 1722

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EDVETAAG 9
           EDVETAAG
Sbjct: 161 EDVETAAG 168
>XP_005273257
          Length = 1726

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EDVETAAG 9
           EDVETAAG
Sbjct: 161 EDVETAAG 168
>NP_004466
          Length = 428

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  EDVETAAG 9
          EDVETA G
Sbjct: 57 EDVETAEG 64
>NP_689835
          Length = 549

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VEDVETAAG 9
           VEDVET +G
Sbjct: 158 VEDVETDSG 166
>NP_075463
          Length = 3013

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    VEDVETAA 8
            VEDV+TAA
Sbjct: 1779 VEDVDTAA 1786
>XP_005258009
          Length = 379

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  EDVETAAG 9
          EDVETA G
Sbjct: 8  EDVETAEG 15
>XP_006719812
          Length = 3019

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    VEDVETAA 8
            VEDV+TAA
Sbjct: 1776 VEDVDTAA 1783
>XP_005248505
          Length = 550

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VEDVETAAG 9
           VEDVET +G
Sbjct: 158 VEDVETDSG 166
>NP_542165
          Length = 428

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  EDVETAAG 9
          ++VETAAG
Sbjct: 16 DEVETAAG 23
>NP_004631
          Length = 428

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  EDVETAAG 9
          ++VETAAG
Sbjct: 16 DEVETAAG 23
>NP_036307
          Length = 471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DVETAAG 9
           DV+TAAG
Sbjct: 176 DVDTAAG 182
>NP_208385
          Length = 415

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DVETAAG 9
           DV+TAAG
Sbjct: 176 DVDTAAG 182
>XP_005252908
          Length = 466

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   DVETAAG 9
           DV+TAAG
Sbjct: 171 DVDTAAG 177
>NP_612450
          Length = 522

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EDVETAAG 9
           +D+ TAAG
Sbjct: 177 DDISTAAG 184
>NP_056131
          Length = 1090

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           + D+ETAA
Sbjct: 985 ISDIETAA 992
>XP_005267542
          Length = 1087

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           + D+ETAA
Sbjct: 982 ISDIETAA 989
>XP_005267541
          Length = 1087

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           + D+ETAA
Sbjct: 982 ISDIETAA 989
>XP_005267544
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VEDVETAA 8
            + D+ETAA
Sbjct: 1053 ISDIETAA 1060
>XP_006715390
          Length = 445

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EDVETAAG 9
           +D+ TAAG
Sbjct: 177 DDISTAAG 184
>NP_001154819
          Length = 572

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   EDVETAAG 9
           EDV  AAG
Sbjct: 194 EDVRAAAG 201
>NP_001154817
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   EDVETAAG 9
           EDV  AAG
Sbjct: 286 EDVRAAAG 293
>NP_060693
          Length = 623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   EDVETAAG 9
           EDV  AAG
Sbjct: 245 EDVRAAAG 252
>NP_001154818
          Length = 652

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   EDVETAAG 9
           EDV  AAG
Sbjct: 274 EDVRAAAG 281
>NP_001154816
          Length = 664

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   EDVETAAG 9
           EDV  AAG
Sbjct: 286 EDVRAAAG 293
>NP_001121371
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VEDVET 6
           VEDVET
Sbjct: 675 VEDVET 680
>NP_001269092
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VEDVET 6
           VEDVET
Sbjct: 625 VEDVET 630
>NP_001121370
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VEDVET 6
           VEDVET
Sbjct: 675 VEDVET 680
>NP_000075
          Length = 746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VEDVET 6
           VEDVET
Sbjct: 605 VEDVET 610
>NP_001821
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VEDVET 6
           VEDVET
Sbjct: 619 VEDVET 624
>NP_001243873
          Length = 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VEDVET 6
           VEDVET
Sbjct: 525 VEDVET 530
>NP_079358
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   EDVETAAG 9
           ED E AAG
Sbjct: 267 EDAEQAAG 274
>NP_002288
          Length = 176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VEDVETAAG 9
           +ED E AAG
Sbjct: 145 LEDFEKAAG 153
>NP_001239546
          Length = 176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VEDVETAAG 9
           +ED E AAG
Sbjct: 145 LEDFEKAAG 153
>XP_006721341
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   EDVETAAG 9
           ED E AAG
Sbjct: 164 EDAEQAAG 171
>XP_006721340
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   EDVETAAG 9
           ED E AAG
Sbjct: 164 EDAEQAAG 171
>XP_006715629
          Length = 1667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    EDVETAA 8
            E+VETAA
Sbjct: 1437 EEVETAA 1443
>XP_005247569
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VEDVETAAG 9
           V+D++ AAG
Sbjct: 324 VQDIKRAAG 332
>XP_005247568
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VEDVETAAG 9
           V+D++ AAG
Sbjct: 324 VQDIKRAAG 332
>NP_078970
          Length = 1667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    EDVETAA 8
            E+VETAA
Sbjct: 1437 EEVETAA 1443
>NP_057022
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VEDVETAAG 9
           V+D++ AAG
Sbjct: 324 VQDIKRAAG 332
>NP_203747
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           VED+ET A
Sbjct: 594 VEDLETDA 601
>NP_001269058
          Length = 1450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           VED+ET A
Sbjct: 621 VEDLETDA 628
>NP_056382
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           ++D+ET A
Sbjct: 117 IQDIETGA 124
>NP_001035931
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EDVETAAG 9
          +DV TAAG
Sbjct: 67 KDVVTAAG 74
>NP_001035930
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EDVETAAG 9
          +DV TAAG
Sbjct: 67 KDVVTAAG 74
>NP_115997
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VEDVETAAG 9
           +ED ET++G
Sbjct: 891 LEDEETSSG 899
>NP_002769
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  EDVETAAG 9
          +DV TAAG
Sbjct: 67 KDVVTAAG 74
>NP_061169
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VEDVET 6
           VED+ET
Sbjct: 110 VEDIET 115
>XP_006726921
          Length = 277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VETAAG 9
           VETAAG
Sbjct: 183 VETAAG 188
>XP_006724404
          Length = 1442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VEDVETAAG 9
           +ED ET++G
Sbjct: 891 LEDEETSSG 899
>XP_006724403
          Length = 2449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VEDVETAAG 9
           +ED ET++G
Sbjct: 772 LEDEETSSG 780
>XP_005261845
          Length = 2568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VEDVETAAG 9
           +ED ET++G
Sbjct: 891 LEDEETSSG 899
>XP_005261844
          Length = 2568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VEDVETAAG 9
           +ED ET++G
Sbjct: 891 LEDEETSSG 899
>XP_005261843
          Length = 2568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VEDVETAAG 9
           +ED ET++G
Sbjct: 891 LEDEETSSG 899
>XP_006722213
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           VED+ET A
Sbjct: 201 VEDLETDA 208
>XP_005258117
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           VED+ET A
Sbjct: 155 VEDLETDA 162
>XP_006722212
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           VED+ET A
Sbjct: 572 VEDLETDA 579
>XP_005258116
          Length = 1430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           VED+ET A
Sbjct: 601 VEDLETDA 608
>XP_005258115
          Length = 1450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           VED+ET A
Sbjct: 621 VEDLETDA 628
>XP_005254096
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           ++D+ET A
Sbjct: 117 IQDIETGA 124
>XP_005254095
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VEDVETAA 8
           ++D+ET A
Sbjct: 117 IQDIETGA 124
>XP_005262765
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VEDVET 6
           VED+ET
Sbjct: 110 VEDIET 115
>XP_005262764
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VEDVET 6
           VED+ET
Sbjct: 110 VEDIET 115
>XP_006714135
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VEDVET 6
           VED+ET
Sbjct: 110 VEDIET 115
>XP_005262763
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VEDVET 6
           VED+ET
Sbjct: 110 VEDIET 115
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296    0.118    0.291 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 531,719
Number of extensions: 769
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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