Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           21     229
NP_004561                                                              21     229
NP_001275703                                                           21     229
XP_005253450                                                           21     229
XP_006719151                                                           21     229
NP_001005329                                                           17    2528
NP_001004748                                                           17    2528
XP_001718723                                                           17    3301
NP_620161                                                              17    4312
NP_740750                                                              17    4312
NP_620386                                                              17    4312
NP_620385                                                              17    4312
NP_996879                                                              17    4312
XP_006713555                                                           17    4312
XP_006713554                                                           17    4312
XP_006710494                                                           17    4312
XP_006710492                                                           17    4312
XP_006710491                                                           17    4312
XP_006710490                                                           17    4312
XP_006710489                                                           17    4312
NP_002444                                                              16    5631
NP_001005369                                                           16    5631
NP_689562                                                              16    5631
XP_005256920                                                           16    5631
XP_006712087                                                           16    5631
XP_005264392                                                           16    5631
XP_006712086                                                           16    5631
NP_001004749                                                           16    5631
NP_057427                                                              16    7355
NP_001241681                                                           16    7355
NP_689955                                                              16    7355
NP_071338                                                              16    7355
XP_006716715                                                           16    7355
NP_115785                                                              15    9605
NP_877963                                                              15    9605
NP_002651                                                              15    9605
NP_005126                                                              15    9605
NP_598408                                                              15    9605
NP_001035959                                                           15    9605
NP_001035962                                                           15    9605
NP_001035960                                                           15    9605
NP_001035961                                                           15    9605
NP_055869                                                              15    9605
NP_036553                                                              15    9605
NP_060862                                                              15    9605
NP_660154                                                              15    9605
XP_005274666                                                           15    9605
XP_005274659                                                           15    9605
XP_005260495                                                           15    9605
XP_006720856                                                           15    9605
XP_006719360                                                           15    9605
XP_005268797                                                           15    9605
XP_005268796                                                           15    9605
XP_005268795                                                           15    9605
XP_005268794                                                           15    9605
XP_005263172                                                           15    9605
NP_612157                                                              15    9605
>NP_001275701
          Length = 1486

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   CVETKQIT 9
           CVETKQIT
Sbjct: 443 CVETKQIT 450
>NP_004561
          Length = 1445

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   CVETKQIT 9
           CVETKQIT
Sbjct: 443 CVETKQIT 450
>NP_001275703
          Length = 1264

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   CVETKQIT 9
           CVETKQIT
Sbjct: 221 CVETKQIT 228
>XP_005253450
          Length = 1486

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   CVETKQIT 9
           CVETKQIT
Sbjct: 443 CVETKQIT 450
>XP_006719151
          Length = 1486

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   CVETKQIT 9
           CVETKQIT
Sbjct: 443 CVETKQIT 450
>NP_001005329
          Length = 313

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   CVETKQI 8
           CV+TKQI
Sbjct: 294 CVKTKQI 300
>NP_001004748
          Length = 313

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   CVETKQI 8
           CV+TKQI
Sbjct: 294 CVKTKQI 300
>XP_001718723
          Length = 1091

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VCVETKQIT 9
           +CV T Q+T
Sbjct: 167 ICVTTTQVT 175
>NP_620161
          Length = 348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VCVETKQIT 9
          +C++ KQIT
Sbjct: 50 LCMDEKQIT 58
>NP_740750
          Length = 325

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VCVETKQIT 9
          +C++ KQIT
Sbjct: 27 LCMDEKQIT 35
>NP_620386
          Length = 165

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VCVETKQIT 9
          +C++ KQIT
Sbjct: 27 LCMDEKQIT 35
>NP_620385
          Length = 188

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VCVETKQIT 9
          +C++ KQIT
Sbjct: 50 LCMDEKQIT 58
>NP_996879
          Length = 2223

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    VCVETKQI 8
            +C+E+KQ+
Sbjct: 1742 LCIESKQL 1749
>XP_006713555
          Length = 257

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VCVETKQIT 9
          +C++ KQIT
Sbjct: 50 LCMDEKQIT 58
>XP_006713554
          Length = 315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VCVETKQIT 9
          +C++ KQIT
Sbjct: 50 LCMDEKQIT 58
>XP_006710494
          Length = 1152

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   VCVETKQI 8
           +C+E+KQ+
Sbjct: 671 LCIESKQL 678
>XP_006710492
          Length = 1351

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   VCVETKQI 8
           +C+E+KQ+
Sbjct: 870 LCIESKQL 877
>XP_006710491
          Length = 1496

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    VCVETKQI 8
            +C+E+KQ+
Sbjct: 1015 LCIESKQL 1022
>XP_006710490
          Length = 2158

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    VCVETKQI 8
            +C+E+KQ+
Sbjct: 1677 LCIESKQL 1684
>XP_006710489
          Length = 2185

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    VCVETKQI 8
            +C+E+KQ+
Sbjct: 1704 LCIESKQL 1711
>NP_002444
          Length = 727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VCVETKQI 8
           VC E KQI
Sbjct: 710 VCYEEKQI 717
>NP_001005369
          Length = 727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VCVETKQI 8
           VC E KQI
Sbjct: 710 VCYEEKQI 717
>NP_689562
          Length = 295

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   CVETKQ 7
           C+ETKQ
Sbjct: 262 CLETKQ 267
>XP_005256920
          Length = 943

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CVETKQIT 9
           CV+ KQ+T
Sbjct: 730 CVQQKQMT 737
>XP_006712087
          Length = 484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VCVETKQI 8
           VC E KQI
Sbjct: 467 VCYEEKQI 474
>XP_005264392
          Length = 727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VCVETKQI 8
           VC E KQI
Sbjct: 710 VCYEEKQI 717
>XP_006712086
          Length = 727

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VCVETKQI 8
           VC E KQI
Sbjct: 710 VCYEEKQI 717
>NP_001004749
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   CVETKQI 8
           CV+T+QI
Sbjct: 292 CVKTRQI 298
>NP_057427
          Length = 3114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VCVETKQIT 9
           +C++T Q+T
Sbjct: 721 MCLKTSQLT 729
>NP_001241681
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   CVETKQ 7
           C+ET+Q
Sbjct: 126 CIETRQ 131
>NP_689955
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  CVETKQI 8
          C ET+Q+
Sbjct: 32 CAETRQV 38
>NP_071338
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VCVETKQ 7
           VCV T+Q
Sbjct: 400 VCVNTRQ 406
>XP_006716715
          Length = 161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   CVETKQ 7
           C+ET+Q
Sbjct: 126 CIETRQ 131
>NP_115785
          Length = 581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   CVETK 6
           CVETK
Sbjct: 549 CVETK 553
>NP_877963
          Length = 1290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VCVETKQIT 9
          V +ET+QIT
Sbjct: 53 VKLETRQIT 61
>NP_002651
          Length = 1291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VCVETKQIT 9
          V +ET+QIT
Sbjct: 53 VKLETRQIT 61
>NP_005126
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VCVETKQI 8
           VC +TK+I
Sbjct: 338 VCSKTKEI 345
>NP_598408
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VCVETKQI 8
           VC +TK+I
Sbjct: 389 VCSKTKEI 396
>NP_001035959
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VCVETKQI 8
           VC +TK+I
Sbjct: 330 VCSKTKEI 337
>NP_001035962
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VCVETKQI 8
           VC +TK+I
Sbjct: 374 VCSKTKEI 381
>NP_001035960
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VCVETKQI 8
           VC +TK+I
Sbjct: 330 VCSKTKEI 337
>NP_001035961
          Length = 1141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VCVETKQI 8
           VC +TK+I
Sbjct: 380 VCSKTKEI 387
>NP_055869
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    VCVETKQIT 9
            +C++  Q+T
Sbjct: 1213 ICLQVNQVT 1221
>NP_036553
          Length = 1914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VCVETKQIT 9
           +C E+K+I+
Sbjct: 237 LCAESKEIS 245
>NP_060862
          Length = 2104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    CVETKQI 8
            CV T+Q+
Sbjct: 2008 CVRTRQV 2014
>NP_660154
          Length = 130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  ETKQIT 9
          ETKQ+T
Sbjct: 88 ETKQVT 93
>XP_005274666
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CVETKQI 8
           CV+ KQI
Sbjct: 405 CVDQKQI 411
>XP_005274659
          Length = 982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CVETKQI 8
           CV+ KQI
Sbjct: 837 CVDQKQI 843
>XP_005260495
          Length = 1330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VCVETKQIT 9
          V +ET+QIT
Sbjct: 53 VKLETRQIT 61
>XP_006720856
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VCVETKQI 8
           VC +TK+I
Sbjct: 340 VCSKTKEI 347
>XP_006719360
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1   VCVETKQIT 9
           +C++  Q+T
Sbjct: 760 ICLQVNQVT 768
>XP_005268797
          Length = 1384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    VCVETKQIT 9
            +C++  Q+T
Sbjct: 1213 ICLQVNQVT 1221
>XP_005268796
          Length = 1403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    VCVETKQIT 9
            +C++  Q+T
Sbjct: 1152 ICLQVNQVT 1160
>XP_005268795
          Length = 1416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    VCVETKQIT 9
            +C++  Q+T
Sbjct: 1165 ICLQVNQVT 1173
>XP_005268794
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    VCVETKQIT 9
            +C++  Q+T
Sbjct: 1213 ICLQVNQVT 1221
>XP_005263172
          Length = 2104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    CVETKQI 8
            CV T+Q+
Sbjct: 2008 CVRTRQV 2014
>NP_612157
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   VCVETKQI 8
           +C++TK+I
Sbjct: 381 LCLKTKEI 388
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.127    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 552,957
Number of extensions: 704
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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